Chlorogenic acid prevents isoproterenol-induced hypertrophy in neonatal rat myocytes

Li, Yanfei; Shen, Dan; Tang, Xiaomei; Li, Xin; Da, Wang; Yan, Hongwei; Song, Rui; Feng, Jian; Li, Ping; Zhang, Jie; Li, Jue

doi:10.1016/j.toxlet.2014.02.016

Cited by 40 publications

(32 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, the increase in levels of intracellular reactive oxygen species (ROS) induced by Iso was inhibited by CGA pretreatment in a dose-dependent manner. These results support the findings of previous studies (22,33,34), suggesting that CGA may be a promising drug for protection against vascular diseases. Furthermore, CGA is widely present in plant leaves, flowers and fruits (35,36), which are used as herbal ingredients in certain traditional Chinese medicines.…”

Section: Discussionsupporting

confidence: 92%

“…It has previously been reported that there is an association between inflammation and ROS (24,25), and that CGA scavenges oxygen free radicals in cells (26,27). Therefore, ROS levels were examined in VSMCs treated with Iso in the absence or presence of CGA treatment.…”

Section: Resultsmentioning

confidence: 99%

“…Chlorogenic acid (CGA) is a naturally occurring polyphenol, which is the main active ingredient in traditional Chinese medicine honeysuckle and eucommia leaves and is present in sunflower seeds, fruits, vegetables, soybeans, wheat and coffee beans. CGA has anticancer, anti-inflammatory and anti-oxidative activities (20–22). CGA is formed by the condensation of caffeic acid and quinic acid, two phenolic compounds.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Chlorogenic acid prevents isoproterenol-induced DNA damage in vascular smooth muscle cells

Wang

Tong

et al. 2016

Molecular Medicine Reports

View full text Add to dashboard Cite

Numerous clinical therapeutic agents have been identified as DNA damaging. The present study revealed that isoproterenol (Iso) resulted in DNA damage in vascular smooth muscle cells (VSMCs) and increased the levels of intracellular oxygen free radicals. Administration of chlorogenic acid (CGA) inhibited this effect. Pretreatment with CGA abrogated the increase in protein expression levels of γ-H2A histone family member X, phosphorylated ataxia telangiectasia mutated, phosphorylated Rad3-related protein, breast cancer 1 and C-terminal Src homologous kinase induced by Iso. In addition, the increase in levels of intracellular reactive oxygen species (ROS) induced by Iso was inhibited by CGA pretreatment in a dose-dependent manner. The results of the present study suggest that CGA may inhibit Iso-induced VSMC damage via the suppression of ROS generation. Therefore, CGA may be a novel agent for the treatment of vascular diseases.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Chlorogenic acid prevents isoproterenol-induced DNA damage in vascular smooth muscle cells

Wang

Tong

et al. 2016

Molecular Medicine Reports

View full text Add to dashboard Cite

show abstract

“…Many studies also showed additional beneficial effects of CA, GA and PA. Indeed, CA has demonstrated anti-inflammatory, anti-diabetic, neuro-protective and cardio-protective properties [28–31]. GA exerts anti-diabetic activities [32], improves hyperglycaemia and glucose tolerance [33], while offering protection against diabetes complications, notably through cardio-protective properties [34, 35].…”

Section: Discussionmentioning

confidence: 99%

Phenolic compounds isolated from fermented blueberry juice decrease hepatocellular glucose output and enhance muscle glucose uptake in cultured murine and human cells

Nachar

Eid

Vinqvist‐Tymchuk

et al. 2017

BMC Complement Altern Med

View full text Add to dashboard Cite

BackgroundWe recently reported that blueberry juice fermented (FJ) with Serratia vaccinii bacterium has antidiabetic activities both in vivo and in vitro. The purpose of this project was to elucidate the effect of FJ on glucose homeostasis in liver and skeletal muscle cells and to identify active fractions/compounds responsible for this effect.MethodsFJ was fractionated using standard chromatography procedures. Hepatic (H4IIE, HepG2) and skeletal muscle cells (C2C12) were treated with maximum non-toxic concentrations of FJ, fractions and isolated compounds thereof. Glucose-6-phosphatase (G6Pase) activity was measured using glucose oxidase method. To measure glucose uptake and glycogen synthase (GS) activity, radioactive assays were used.ResultsFractionation of FJ yielded seven fractions. FJ and its phenolic fractions F2, F3-1 and F3-2 respectively inhibited G-6Pase by 31, 45, 51 and 26%; activated GS by 2.3-, 2.3-, 2.2- and 2-fold; and stimulated glucose uptake by 19, 25, 18 and 15%, as compared to DMSO vehicle control. Subfractionation of the active fractions yielded 4 compounds (catechol, chlorogenic, gallic and protocatechuic acid). Catechol, yielding the greatest bioactivity in G6Pase and glucose uptake assays, decreased G6Pase activity by 54%, increased GS by 2-fold and stimulated glucose uptake by 44% at 45.5 μM.ConclusionsThis study identifies novel potential antidiabetic compounds that can help standardize FJ.Electronic supplementary materialThe online version of this article (doi:10.1186/s12906-017-1650-2) contains supplementary material, which is available to authorized users.

show abstract

“…The level of the intracellular ROS was reduced and the nuclear translocation of NF-κB was blocked, whereas NF-κBIA, an inhibitor of NF-κB, was upregulated accordingly. These data reveal that chlorogenic acid may inhibit cardiac hypertrophy by attenuating NF-κB signaling pathway and suppressing ROS production (Li et al, 2014). …”

Section: Mechanisms Of Plant Products In the Attenuation Of Cvdsmentioning

confidence: 99%

Chinese Herbal Medicine on Cardiovascular Diseases and the Mechanisms of Action

2016

View full text Add to dashboard Cite

Cardiovascular diseases are the principal cause of death worldwide. The potentially serious adverse effects of therapeutic drugs lead to growing awareness of the role of Chinese herbal medicine in the treatment of cardiovascular diseases. Chinese herbal medicine has been widely used in many countries especially in China from antiquity; however, the mechanisms by which herbal medicine acts in the prevention and treatment of cardiovascular diseases are far from clear. In this review, we briefly describe the characteristics of Chinese herbal medicine by comparing with western medicine. Then we summarize the formulae and herbs/natural products applied in the clinic and animal studies being sorted according to the specific cardiovascular diseases. Most importantly, we elaborate the existing investigations into mechanisms by which herbal compounds act at the cellular levels, including vascular smooth muscle cells, endothelial cells, cardiomyocytes and immune cells. Future research should focus on well-designed clinic trial, in-depth mechanic study, investigations on side effects of herbs and drug interactions. Studies on developing new agents with effectiveness and safety from traditional Chinese medicine is a promising way for prevention and treatment of patients with cardiovascular diseases.

show abstract

Chlorogenic acid prevents isoproterenol-induced hypertrophy in neonatal rat myocytes

Cited by 40 publications

References 44 publications

Chlorogenic acid prevents isoproterenol-induced DNA damage in vascular smooth muscle cells

Chlorogenic acid prevents isoproterenol-induced DNA damage in vascular smooth muscle cells

Phenolic compounds isolated from fermented blueberry juice decrease hepatocellular glucose output and enhance muscle glucose uptake in cultured murine and human cells

Chinese Herbal Medicine on Cardiovascular Diseases and the Mechanisms of Action

Contact Info

Product

Resources

About