Chlorogenic acid improves intestinal barrier functions by suppressing mucosa inflammation and improving antioxidant capacity in weaned pigs

Chen, Jiali; Yu, Bing; Chen, Shuai; Huang, Zhiqing; Mao, Xiangbing; Zheng, Ping; Yu, Jie; Luo, Junqiu; He, Jun

doi:10.1016/j.jnutbio.2018.06.005

Cited by 127 publications

(161 citation statements)

References 53 publications

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“…Intestine mucosal damage was usually associated with inflammation [8]. Previous studies have reported that weaning stress could easily trigger intestinal inflammation in pigs [46].…”

Section: Discussionmentioning

confidence: 99%

“…Early weaned piglets are prone to oxidative stress, which often causes damage to the intestinal mucosa [8]. A previous study showed that decreasing oxidative stress was a main reason for improving intestinal development in weaned piglets [28].…”

Section: Discussionmentioning

confidence: 99%

“…The determination of intestinal antioxidant parameters was proceeded as previously described in Chen et al [8]. The jejunal mucosa samples were homogenized in ice-cold saline solution (1:9, w/v), followed by centrifugation at 2500× g for 10 min at 4 • C. The supernatant was prepared for further determination.…”

Section: Intestinal Antioxidant Parameters Determinationmentioning

confidence: 99%

“…A previous study demonstrated that oxidative stress is strongly linked to the alteration of gut microbiota [7]. Moreover, oxidative stress suppresses intestinal development [8], weakens intestinal digestion and absorption [9], and induces mucosa inflammation and cell apoptosis [10], which can result in growth restriction, disease, and even death in piglets [11,12]. Therefore, decreasing postweaning oxidative stress is crucial for weaned piglets.…”

Section: Introductionmentioning

confidence: 99%

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Effects of a Diet Supplemented with Exogenous Catalase from Penicillium notatum on Intestinal Development and Microbiota in Weaned Piglets

Zhao

Zhang

et al. 2020

Microorganisms

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This study aims to investigate the effects of exogenous catalase (CAT), an antioxidative enzyme from microbial cultures, on intestinal development and microbiota in weaned piglets. Seventy-two weaned piglets were allotted to two groups and fed a basal diet or a basal diet containing 2.0 g/kg exogenous CAT. Results showed that exogenous CAT increased (p < 0.05) jejunal villus height/crypt depth ratio and intestinal factors (diamine oxidase and transforming growth factor-α) concentration. Moreover, dietary CAT supplementation enhanced the antioxidative capacity, and decreased the concentration of pro-inflammatory cytokine in the jejunum mucosa. Exogenous CAT did not affect the concentration of short-chain fatty acids, but decreased the pH value in colonic digesta (p < 0.05). Interestingly, the relative abundance of Bifidobacterium and Dialister were increased (p < 0.05), while Streptococcus and Escherichia-Shigella were decreased (p < 0.05) in colonic digesta by exogenous CAT. Accordingly, decreased (p < 0.05) predicted functions related to aerobic respiration were observed in the piglets fed the CAT diet. Our study suggests a synergic response of intestinal development and microbiota to the exogenous CAT, and provides support for the application of CAT purified from microbial cultures in the feed industry.

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“…Intestine mucosal damage was usually associated with inflammation [8]. Previous studies have reported that weaning stress could easily trigger intestinal inflammation in pigs [46].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Intestinal Antioxidant Parameters Determinationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effects of a Diet Supplemented with Exogenous Catalase from Penicillium notatum on Intestinal Development and Microbiota in Weaned Piglets

Zhao

Zhang

et al. 2020

Microorganisms

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show abstract

“…Nrf2, a key transcription factor, plays an essential role in regulating the activity of endogenous antioxidant enzymes to resist oxidative stress [35]. A previous study in piglets also showed that the activity of antioxidative enzymes is enhanced by increasing the mRNA expression level of Nrf2 [36]. Moreover, Nrf2 regulates the activity of HO-1, an important antioxidative enzyme regulating the ROS levels of cells [19] and serving as a sensitive and reliable indicator of cellular oxidative stress [37].…”

Section: Discussionmentioning

confidence: 99%

Maternal Dietary Fiber Composition during Gestation Induces Changes in Offspring Antioxidative Capacity, Inflammatory Response, and Gut Microbiota in a Sow Model

Liu

Zhang

et al. 2019

IJMS

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To study the effects of maternal dietary fiber composition during gestation on offspring antioxidant capacity, inflammation, and gut microbiota composition, we randomly assigned 64 gilts to four treatments and administered diets with an insoluble/soluble fiber ratio of 3.89 (R1), 5.59 (R2), 9.12 (R3), and 12.81 (R4). Sow samples (blood and feces at gestation 110) and neonatal samples (blood, liver, and colonic contents) were collected. The results showed that sows and piglets in R1 and R2 had higher antioxidant enzyme activity and lower pro-inflammatory factor levels than those in R3 and R4. Moreover, piglets in R1 and R2 had higher liver mRNA expression of Nrf2 and HO-1 and lower NF-κB than piglets in R4. Interestingly, maternal fiber composition not only affected the production of short-chain fatty acids (SCFAs) in sow feces but also influenced the concentrations of SCFAs in the neonatal colon. Results of high-throughput sequencing showed that piglets as well as sows in R1 and R2 had microbial community structures distinct from those in R3 and R4. Therefore, the composition of dietary fiber in pregnancy diet had an important role in improving antioxidant capacity and decreasing inflammatory response of mothers and their offspring through modulating the composition of gut microbiota.

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Dietary phytochemicals modulate intestinal epithelial barrier dysfunction and autoimmune diseases

et al. 2021

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The intestinal epithelium acts as a key defensive barrier that protects internal organs from the detrimental gut environment. The homeostasis of the gut epithelium may be altered by environmental conditions and exogenous pathogens that can impair the integrity of the gut barrier, leading to immune response associated with low‐grade systemic inflammation, a known contributor to metabolic and inflammatory diseases. Autoimmune diseases (ADs) are a collection of abnormalities of the immune system, in which the immune system of an individual acts against healthy organs or systems, due to a failure in antigenic recognition. Hence, this review aims to focus on modulators of intestinal epithelial barrier dysfunction with effects on autoimmune disorders. All data on dietary phytochemicals and their impact on the modulation of the intestinal epithelium barrier and various ADs were collected from electronic searches of library databases (PubMed, Science Direct, and Google Scholar). An electronic search was conducted using PubMed, Science Direct, and Google Scholar by finding the keywords “phytochemicals” AND “bioactive compounds” AND “flavonoids” AND “polyphenols” OR “intestinal epithelium barrier” OR “autoimmune diseases” OR “inflammatory diseases” in “Title/Abstract/Keywords,” with the date from January 2011 to December 2020, to identify all published studies (in vitro, in vivo, clinical, and case‐control) that have investigated the connection between dietary phytochemicals and their various beneficial effects. Dietary phytochemicals are promising key modulators, stabilizing the integrity of the intestinal barrier and attenuating the progression of ADs. Health‐modulatory information was gathered and orchestrated in a suitable place in this review.

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Chlorogenic acid improves intestinal barrier functions by suppressing mucosa inflammation and improving antioxidant capacity in weaned pigs

Cited by 127 publications

References 53 publications

Effects of a Diet Supplemented with Exogenous Catalase from Penicillium notatum on Intestinal Development and Microbiota in Weaned Piglets

Effects of a Diet Supplemented with Exogenous Catalase from Penicillium notatum on Intestinal Development and Microbiota in Weaned Piglets

Maternal Dietary Fiber Composition during Gestation Induces Changes in Offspring Antioxidative Capacity, Inflammatory Response, and Gut Microbiota in a Sow Model

Dietary phytochemicals modulate intestinal epithelial barrier dysfunction and autoimmune diseases

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