Chlorogenic acid from coffee beans: evaluating the evidence for a blood pressure–regulating health claim

Abstract

The consumption of coffee has been associated with a number of health benefits, including a reduced risk of cardiovascular disease. Hypertension is an important risk factor for adverse cardiovascular events. Coffee may help reduce blood pressure (BP) in humans, which might be attributable to its polyphenolic compound, chlorogenic acid. The high incidence of hypertension among Canadians underscores the need for new and effective strategies to reduce BP. Dietary interventions may constitute such a strategy, but consumers need to be informed about which foods are most effective for regulating BP. To guide healthy eating, Health Canada permits the use of health claims on the labels of foods that confer health benefits. Currently, there is only one health claim for BP regulation. Additional health claims for foods that assist in BP regulation are therefore warranted. This review provides background information on chlorogenic acid and examines the evidence regarding the use of chlorogenic acid for BP regulation in the context of Health Canada's health claims framework.

Factors affecting intake, metabolism and health benefits of phenolic acids: do we understand individual variability?

“…The potential preventive effect of HCAs on several chronic diseases has been widely reviewed in the recent years. HCA derivatives, in particular chlorogenic acids, have been shown to exert health benefits in the management of obesity, cardiovascular diseases, type 2 diabetes mellitus, and metabolic syndrome [2,[88][89][90][91][92], while some antioxidant and neuroprotective effects have also been reported [93][94][95]. Nevertheless, current evidence is still inconsistent and insufficient to support robust health claims, mostly because the co-occurrence of other plant bioactives (e.g., caffeine and hydroxyhydroquinone in coffee, fibre in wholegrain products, and flavonoids in berries and fruits) in the main dietary sources of HCAs hinders the elucidation of the putative health benefits exerted by these compounds.…”

“…Some studies suggest that chlorogenic acids may cause significant reductions in systolic and diastolic blood pressure [100,102,103], but other studies have instead reported a lack of significant blood pressure reduction [104][105][106]. The differences could be attributed to the antihypertensive effects of chlorogenic acids only occurring in subjects with mild hypertension and not in normotensives [88,107]. Moreover, the decrease in blood pressure upon consumption of caffeoylquinic acids from coffee could be inhibited by the presence of hydroxyhydroquinone in brewed coffee.…”

“…Hydroxyhydroquinone is generated during the roasting of coffee beans, and it is a compound to which prohypertensive effects have been attributed [104]. In addition, dose-response effects of HCAs on blood pressure are not clear [88]. These controversies and lack of robust evidence make the development of health claims or guidelines on the effects of HCA-rich diet on reduced blood pressure extremely difficult.…”

Zwyczaje żywieniowe osób pracujących w systemie zmianowym a stan ich zdrowia

“…W przegl dzie bada od 1966 do 2002 r. nie odnaleziono dowodów na to, e picie kawy mo e negatywnie wp ywa na nawodnienie organizmu. Ponadto publikowane dane wskazuj , e kawa mo e by pomocna w obni aniu ci nienia t tniczego, dzi ki zawarto ci kwasu chlorogenowego (Loader i in., 2017).…”

Preliminary evaluation of quince (Cydonia oblonga Mill.) fruit as extraction source of antioxidant phytoconstituents for nutraceutical and functional food applications

“…1,2,19,22 CQA and the CGA, particularly, are active in mitigating oxidative stress and the adverse effects due to an unbalanced intracellular redox state. 23,24 CGA has been extensively studied for its role on human health, showing potential activity in the regulation of blood pressure, 23,25 and a wide range of potential health benefits, including its antidiabetic, anticarcinogenic, anti-inflammatory and anti-obesity effects. [23][24][25][26] CGA and CQA, together, may provide a non-pharmacological and non-invasive approach for treatment or prevention of some chronic diseases.…”