Chlorogenic Acid Extends the Lifespan of<i>Caenorhabditis elegans</i>via Insulin/IGF-1 Signaling Pathway

Zheng, Shanqing; Huang, Xiande; Xing, Ti-Kun; Ding, Aijun; Wu, Gui-Sheng; Luo, Huai‐Rong

doi:10.1093/gerona/glw105

Cited by 65 publications

(94 citation statements)

References 75 publications

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“…1: Gallic acid, 2: protocatechuic acid, 3: catechin, 4: p-hydroxy benzoic acid, 5: chlorogenic acid, 6: caffeic acid, 7: epicatechin, 8: syringic acid, 9: vanillin, 10: p-coumaric acid, 11: ferulic acid, 12: sinapinic acid, 13: benzoic acid, 14: o-coumaric acid, 15: rutin, 16: hesperidin, 17: rosmarinic acid, 18: eriodictyol, 19: cinnamic acid, 20: quercetin, 21: luteolin, 22: kaempferol, 23: apigenin. antihypertension, antiobesity, and neuroprotective effects. In concordance with our results, chlorogenic acid was recently found to extend the lifespan of C. elegans by up to 20.1%, delay the age-related decline of body movement, and improve stress resistance (Zheng et al, 2017). The authors performed subsequent genetic analysis with worm mutants and revealed that chlorogenic acid extends the lifespan of C. elegans mainly through DAF-16 in the insulin/IGF-1 signaling pathway.…”

Section: Discussionsupporting

confidence: 90%

Evaluation of the lifespan extension effects of several Turkish medicinal plants in Caenorhabditis elegans

Ergen¹,

Hoşbaş²,

Orhan³

et al. 2018

Turk J Biol

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Introduction Aging is a process that leads to the functional loss of an organism and ultimately results in death. The medical sciences have long sought to improve quality of life and increase maximum life expectancy (Sinclair, 2005; Baur et al., 2006). Aging research has become important because it is related to not only prolonging life expectancy and healthy aging but also preventing age-related diseases, such as obesity, diabetes, atherosclerosis, cancer, depression, and Alzheimer and Parkinson diseases (Baur et al., 2006). Caenorhabditis elegans is an advantageous model organism that is widely used in longevity studies because its genome has been extensively studied, it is easily manipulated under laboratory conditions, and it has a 3-week lifespan. A variety of different genes and pathways have been shown to be involved in the progression of aging in C. elegans (Schaffitzel and Hertweck, 2006). The main pathways that have been implicated in aging/longevity include the following: the insulin/IGF-1 like signaling pathway, JNK signaling pathway, oxidative stress pathway, TOR signaling pathway, and mitochondrial signaling pathway. The insulin signaling pathway has been demonstrated to be one of the most widely studied and influential pathways in C. elegans aging research (Warner, 2005). The vast majority of all drugs are obtained from plant sources, and there is a high probability that a drug candidate molecule has been developed from a plant that is used as a medicinal plant. It has previously been reported that blueberry Vaccinium angustifolium Aiton (Ericaceae) extended lifespan in C. elegans (Wilson et al., 2006), resveratrol increased lifespan in mice (Baur et al., 2006), and n-butanol extracts from Platycladus orientalis (L.) Franco (Cupressaceae) and water extracts from Damnacanthus officinarum C.C.Huang (Rubiaceae) had lifespan-extending effects in C. elegans (Yang et al., 2012; Liu et al., 2013). Extended lifespans were also observed in C. elegans treated with products from traditional Chinese medicine (Wang et al., 2014). Turkey has a rich traditional medicine culture, and many plants are currently used as panacea. We have previously

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Section: Discussionsupporting

confidence: 90%

Evaluation of the lifespan extension effects of several Turkish medicinal plants in Caenorhabditis elegans

Ergen¹,

Hoşbaş²,

Orhan³

et al. 2018

Turk J Biol

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“…Reduction in insulin signaling is a beneficial way to increase lifespan (52)(53)(54), and complete and partial reduction of insulin release increases lifespan in flies (55). In our system, we had strong evidence that insulin signaling was reduced through at least 2 different, synergistically acting mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Nutritional regimens with periodically recurring phases of dietary restriction extend lifespan in Drosophila

Romey-Glüsing

Hoffmann

et al. 2018

FASEB j.

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Nutritional interventions such as caloric and dietary restriction increase lifespan in various animal models. To identify alternative and less demanding nutritional interventions that extend lifespan, we subjected fruit flies ( Drosophila melanogaster) to weekly nutritional regimens that involved alternating a conventional diet with dietary restriction. Short periods of dietary restriction (up to 2 d) followed by longer periods of a conventional diet yielded minimal increases in lifespan. We found that 3 or more days of contiguous dietary restriction (DR) was necessary to yield a lifespan extension similar to that observed with persistent DR. Female flies were more responsive to these interventions than males. Physiologic changes known to be associated with prolonged DR, such as reduced metabolic rates, showed the same time course as lifespan extension. Moreover, concurrent transcriptional changes indicative of reduced insulin signaling were identified with DR. These physiologic and transcriptional changes were sustained, as they were detectable several days after switching to conventional diets. Taken together, diets with longer periods of DR extended lifespan concurrently with physiologic and transcriptional changes that may underlie this increase in lifespan.-Romey-Glüsing, R., Li, Y., Hoffmann, J., von Frieling, J., Knop, M., Pfefferkorn, R., Bruchhaus, I., Fink, C., Roeder, T. Nutritional regimens with periodically recurring phases of dietary restriction extend lifespan in Drosophila.

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“…All strains were cultured on fresh NGM plates for 2–3 generations without starvation, and lifespan analysis was conducted at 20°C, unless otherwise stated. Late L4 larvae or young adults were transferred to NGM plates containing inactivated OP50 (65°C for 30 min) and 20 μM FUdR to inhibit progeny growth [ 7 , 39 ]. The day that L4 larvae or young adults were transferred to an NGM plate was defined as test day 0.…”

Section: Methodsmentioning

confidence: 99%

Aspirin increases metabolism through germline signalling to extend the lifespan of Caenorhabditis elegans

Huang

Wan

et al. 2017

PLoS ONE

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Aspirin is a prototypic cyclooxygenase inhibitor with a variety of beneficial effects on human health. It prevents age-related diseases and delays the aging process. Previous research has shown that aspirin might act through a dietary restriction-like mechanism to extend lifespan. To explore the mechanism of action of aspirin on aging, we determined the whole-genome expression profile of Caenorhabditis elegans treated with aspirin. Transcriptome analysis revealed the RNA levels of genes involved in metabolism were primarily increased. Reproduction has been reported to be associated with metabolism. We found that aspirin did not extend the lifespan or improve the heat stress resistance of germline mutants of glp-1. Furthermore, Oil Red O staining showed that aspirin treatment decreased lipid deposition and increased expression of lipid hydrolysis and fatty acid β-oxidation-related genes. The effect of germline ablation on lifespan was mainly mediated by DAF-12 and DAF-16. Next, we performed genetic analysis with a series of worm mutants and found that aspirin did not further extend the lifespans of daf-12 and daf-16 single mutants, glp-1;daf-12 and glp-1;daf-16 double mutants, or glp-1;daf-12;daf-16 triple mutants. The results suggest that aspirin increase metabolism and regulate germline signalling to activate downstream DAF-12 and DAF-16 to extend lifespan.

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Chlorogenic Acid Extends the Lifespan ofCaenorhabditis elegansvia Insulin/IGF-1 Signaling Pathway

Cited by 65 publications

References 75 publications

Evaluation of the lifespan extension effects of several Turkish medicinal plants in Caenorhabditis elegans

Evaluation of the lifespan extension effects of several Turkish medicinal plants in Caenorhabditis elegans

Nutritional regimens with periodically recurring phases of dietary restriction extend lifespan in Drosophila

Aspirin increases metabolism through germline signalling to extend the lifespan of Caenorhabditis elegans

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