Chlorogenic acid confers robust neuroprotection against arsenite toxicity in mice by reversing oxidative stress, inflammation, and apoptosis

Metwally, Dina M.; Alajmi, Reem A.; El‐Khadragy, Manal F.; Yehia, Hany M.; Al-Megrin, Wafa Abdullah I.; Akabawy, Ahmed M.A.; Amin, Hatem K.; Moneim, Ahmed E. Abdel

doi:10.1016/j.jff.2020.104202

Cited by 40 publications

(22 citation statements)

References 41 publications

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“…Ae-Sim Cho et al found that chlorogenic acid exhibits anti-obesity property and improves lipid metabolism in high-fat diet-induced obese mice [ 26 ]. Similar conclusions can be based on Metwally results [ 27 ]. This phenomenon’s possible mechanism is that CGA promotes fatty acid catabolism by regulating the AMPK pathway [ 28 ].…”

Section: Discussionsupporting

confidence: 90%

The Effect of Ilex × meserveae S. Y. Hu Extract and Its Fractions on Renal Morphology in Rats Fed with Normal and High-Cholesterol Diet

Kuropka

Zwyrzykowska-Wodzińska

Kupczyński

et al. 2021

Foods

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Therapeutic properties of Ilex species are widely used in natural medicine. Ilex × meserveae may become a potential substitute for Ilex paraguariensis (Yerba Mate). As a part of the preliminary safety verification of this European Ilex hybrid vs. Yerba Mate, an eight-week study concerning the impact of regular administration of leaves of both species on kidneys was conducted. The standard water infusion and three dominant fractions of Ilex × meserveae leaves’ constituents (polyphenols, saponins and less polar terpenoids) were separately tried on 96 male Wistar rats divided into 8-member groups. Animals were divided into two basic nutritional groups: the first one was rats fed standard feed and the second on was rats fed with high-cholesterol diet (20 g of cholesterol per kg of standard feed). Postmortem morphometric evaluation of stained kidney samples concerned the filtration barrier elements, which are crucial in proper diuresis. The results showed that saponins present in the hydroalcoholic dry extract (administered in a dose of 10 mg/kg of body weight/day) as well as in water infusions (1:20) from Ilex × meserveae and Ilex paraguariensis do not demonstrate nephrotoxicity but conversely, have a protective role on kidney status in animals fed with a normal diet and in a high-cholesterol diet.

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Section: Discussionsupporting

confidence: 90%

The Effect of Ilex × meserveae S. Y. Hu Extract and Its Fractions on Renal Morphology in Rats Fed with Normal and High-Cholesterol Diet

Kuropka

Zwyrzykowska-Wodzińska

Kupczyński

et al. 2021

Foods

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“…However, the excessive occurrence of apoptosis in testicular tissues can lead to infertility in men due to some factors (Richburg, 2000). Caspase‐3, one of the cysteine aspartic acid protease family members, has an important role in the apoptosis pathway (Metwally et al., 2020; Yardim et al., 2020; Yardım et al., 2020), and heavy metals are known to cause apoptosis by initiating caspase‐3 activation. (Wang et al., 2017).…”

Section: Discussionmentioning

confidence: 99%

Chrysin protects against testicular toxicity caused by lead acetate in rats with its antioxidant, anti‐inflammatory, and antiapoptotic properties

et al. 2020

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In the present study, the protective effects of chrysin (CHR) against testicular damage caused by lead acetate (PbAc) were examined. In this way, 30 min after rats were given 25 and 50 mg/kg/b.w CHR orally for seven consecutive days, 30 mg/kg/b.w PbAc was administered orally. In biochemical analysis of testicular tissue, it was found that PbAc-reduced antioxidant parameters [glutathione peroxidase (GPx), glu

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“…Chlorogenic acid (CGA) is the abundantly available biologically active polyphenolic constituent of coffee, possessing arrays of biological activities including antioxidant, antibacterial, hepato-and cardioprotective, hypoglycemic, anti-obesity, antiinflammatory, and anticarcinogenic effects (Tajik et al, 2017;Naveed et al, 2018). An earlier study reported that CGA can ameliorate Pb-induced renal toxicity (Zhang T. et al, 2019) and arsenite toxicity (Metwally et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of Chlorogenic Acid and Its Analogues on Lead-Induced Developmental Neurotoxicity Through Modulating Oxidative Stress and Autophagy

Wang

Paudel

et al. 2021

Front. Mol. Biosci.

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Lead (Pb) is among the deleterious heavy metal and has caused global health concerns due to its tendency to cause a detrimental effect on the development of the central nervous system (CNS). Despite being a serious health concern, treatment of Pb poisoning is not yet available, reflecting the pressing need for compounds that can relieve Pb-induced toxicity, especially neurotoxicity. In the quest of exploring protective strategies against Pb-induced developmental neurotoxicity, compounds from natural resources have gained increased attention. Chlorogenic acid (CGA) and its analogues neochlorogenic acid (NCGA) and cryptochlorogenic acid (CCGA) are the important phenolic compounds widely distributed in plants. Herein, utilizing zebrafish as a model organism, we modeled Pb-induced developmental neurotoxicity and investigated the protective effect of CGA, NCGA, and CCGA co-treatment. In zebrafish, Pb exposure (1,000 μg/L) for 5 days causes developmental malformation, loss of dopaminergic (DA) neurons, and brain vasculature, as well as disrupted neuron differentiation in the CNS. Additionally, Pb-treated zebrafish exhibited abnormal locomotion. Notably, co-treatment with CGA (100 µM), NCGA (100 µM), and CCGA (50 µM) alleviated these developmental malformation and neurotoxicity induced by Pb. Further underlying mechanism investigation revealed that these dietary phenolic acid compounds may ameliorate Pb-induced oxidative stress and autophagy in zebrafish, therefore protecting against Pb-induced developmental neurotoxicity. In general, our study indicates that CGA, NCGA, and CCGA could be promising agents for treating neurotoxicity induced by Pb, and CCGA shows the strongest detoxifying activity.

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Chlorogenic acid confers robust neuroprotection against arsenite toxicity in mice by reversing oxidative stress, inflammation, and apoptosis

Cited by 40 publications

References 41 publications

The Effect of Ilex × meserveae S. Y. Hu Extract and Its Fractions on Renal Morphology in Rats Fed with Normal and High-Cholesterol Diet

The Effect of Ilex × meserveae S. Y. Hu Extract and Its Fractions on Renal Morphology in Rats Fed with Normal and High-Cholesterol Diet

Chrysin protects against testicular toxicity caused by lead acetate in rats with its antioxidant, anti‐inflammatory, and antiapoptotic properties

Protective Effect of Chlorogenic Acid and Its Analogues on Lead-Induced Developmental Neurotoxicity Through Modulating Oxidative Stress and Autophagy

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