Chlorogenic Acid and Its Metabolitem-Coumaric Acid Evoke Neurite Outgrowth in Hippocampal Neuronal Cells

Abstract

We evaluated the neurotrophic activity of dietary polyphenols by using primary cultures of fetal rat hippocampal neurons in a serum-free medium. Among the tested compounds, chlorogenic acid and its metabolite, m-coumaric acid, together with catechins and flavanone, were found to promote neuronal differentiation comparable to the phytochemical, honokiol, which has been reported to show potent neurotrophic activity. The present findings may contribute to the development of further neurotrophic studies on dietary polyphenols and their metabolites.

Phytocomponent p-Hydroxycinnamic acid inhibits T-cell activation by modulation of protein kinase C-θ-dependent pathway

“…It has been studied that o-HCA ameliorates obesity in rats [22] and m-HCA promotes neuronal differentiation and comparable to the phytochemical honokiol which has been reported to show potent neurotrophic activity [23]. Interestingly, however, it has been demonstrated that all three isomers have an anti-oxidant activity in relation to the PKC pathway [24].…”

Protective effect of apple (Ralls) polyphenol extract against aluminum-induced cognitive impairment and oxidative damage in rat

“…It has been reported in literature that APE reduce the MDA concentration and increases the levels of SOD and catalase in rat gastric mucosa with oxidative damage (Graziani et al, 2005). The chlorogenic acid (ChA), which is 45.1% of the total phenol content in APE has been shown to have multiple biological effects, including antioxidant (Feng et al, 2005), neuroprotective (Lee et al, 2008;Kwon et al, 2010) and neurotrophic activity (Ito et al, 2008). In H 2 O 2 -induced oxidative neuronal death, ChA up-regulated the antioxidant enzyme and the anti-apoptotic proteins, which probably exerted a neuroprotective effect on this population of neurons (Kim et al, 2012).…”

Chlorogenic acid, a polyphenol in coffee, protects neurons against glutamate neurotoxicity

“…Morphometric analysis of developing primary culture neurons revealed that 10 μM of CGA is effective in promoting neurite growth (Ito et al, 2008). The morphological changes of neurons treated with glutamate in the presence of CGA was weaker than that of vehicle-treated and MK-801-treated neurons (Fig.…”