Chlorogenic acid ameliorates endotoxin-induced liver injury by promoting mitochondrial oxidative phosphorylation

Zhou, Yan; Ruan, Zheng; Zhou, Lili; Shu, Xugang; Sun, Xiaohong; Mi, Shumei; Yang, Yuhui; Yin, Yulong

doi:10.1016/j.bbrc.2015.12.094

Cited by 33 publications

(16 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This conclusion is further supported by a previous study, in which Zhou et al. indicated that CGA mends endotoxin‐induced liver injury by promoting mitochondrial oxidative phosphorylation through the modulation of AMPK/PGC‐1 signaling …”

Section: Discussionsupporting

confidence: 79%

Chlorogenic Acid Protects Against oxLDL‐Induced Oxidative Damage and Mitochondrial Dysfunction by Modulating SIRT1 in Endothelial Cells

Tsai

Hung

Chan

et al. 2018

Molecular Nutrition Food Res

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 79%

Chlorogenic Acid Protects Against oxLDL‐Induced Oxidative Damage and Mitochondrial Dysfunction by Modulating SIRT1 in Endothelial Cells

Tsai

Hung

Chan

et al. 2018

Molecular Nutrition Food Res

View full text Add to dashboard Cite

show abstract

“…Therefore, maintaining normal intestinal digestion and absorption function plays key roles in preventing the negative effects of weaning stress on growth performance in weaned pigs. CGA is a naturally polyphenol compound found in various plants, and its beneficial effects in health have been investigated in vitro and in vivo (Johnston et al, 2005;Palócz et al, 2016;Ruan et al, 2016;Zhou et al, 2016b). Thus, CGA has been getting increased attention in animal production.…”

Section: Discussionmentioning

confidence: 99%

Dietary chlorogenic acid improves growth performance of weaned pigs through maintaining antioxidant capacity and intestinal digestion and absorption function

Chen

Li²,

et al. 2018

Journal of Animal Science

View full text Add to dashboard Cite

Chlorogenic acid (CGA) is a natural phenolic acid, which is an important component of biologically active dietary phenols isolated from various species. Two experiments were conducted to investigate the effects of CGA on growth performance, antioxidant capacity, nutrient digestibility, diarrhea incidence, intestinal digestion and absorption function, and the expression levels of intestinal digestion and absorption-related genes in weaned pigs. In Exp. 1, 200 weaned pigs were randomly allotted to four dietary treatments and fed with a basal diet or a basal diet supplemented with 250, 500, or 1,000 mg/kg CGA, respectively, in a 14-d trial. Pigs on the 1,000 mg/kg CGA-supplemented group had greater (P < 0.05) G:F compared with those on the control (CON) group. In Exp. 2, 24 weaned pigs were randomly allotted to two groups and fed with a basal diet (CON group) or a basal diet supplemented with 1,000 mg/kg CGA (the optimum does from Exp. 1; CGA group). After a 14-d trial, 8 pigs per treatment were randomly selected to collect serum and intestinal samples. Compared with the CON group, the ADG, G:F, as well as the apparent total tract digestibility of CP, crude fat, and ash were increased (P < 0.05), whereas the diarrhea incidence was decreased (P < 0.05) in the CGA group. Pigs on the CGA group had greater (P < 0.05) serum albumin and IGF-1, and lower (P < 0.05) serum urea nitrogen than pigs on the CON group. Furthermore, dietary CGA supplementation enhanced (P < 0.05) the activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) in the serum, the activity of maltase in the jejunum and ileum, as well as the activities of sucrase and alkaline phosphatase (AKP) in the jejunum. The mRNA levels of sodium glucose transport protein-1 (SGLT1) and zinc transporter-1 (ZNT1) in the duodenum and the mRNA levels of SGLT1, glucose transporter-2 (GLUT2), and divalent metal transporter-1 (DMT1) in the jejunum were upregulated (P < 0.05) in pigs fed the CGA diet. These results suggested that dietary CGA supplementation has the potentials to improve the growth performance and decrease the diarrhea incidence of the weaned pigs, possibly through improving the antioxidant capacity and enhancing the intestinal digestion and absorption function.

show abstract

“…Chinese medicine is thought to be an effective way to nd new antidepressants. 4 Chlorogenic acid (3-O-caffeoylquinic acid, CGA) is not only a key constituent of coffee, which is considered as a benecial substance for depression as its properties of antiinammatory and antioxidant, [5][6][7] but also an important active ingredient of many traditional Chinese medicines, like Eucommiae cortex (Duzhong), honeysuckle ower (Jinyinhua), etc. Studies have shown that CGA could reduce the production of a variety of pro-inammatory cytokines, which is consistent with the neuroinammatory hypotheses of depression and the effects of current antidepressant therapies.…”

Section: Introductionmentioning

confidence: 99%

A urinary metabolomics (GC-MS) strategy to evaluate the antidepressant-like effect of chlorogenic acid in adrenocorticotropic hormone-treated rats

et al. 2018

View full text Add to dashboard Cite

Major depressive disorder (MDD) is a chronic recurring illness that seriously affects human health.Chlorogenic acid (CGA), an important polyphenol extracted from Eucommia ulmoides Oliver bark, has been reported to have anti-depression, neuroprotection, memory improvement and other pharmacological effects. However, little is known about the underlying mechanisms of CGA on the treatment of depression. Here, we investigated the antidepressant-like effects of CGA on an adrenocorticotropic hormone (ACTH)-treated rat model. Thirty-two male Wistar rats were randomly These results of the behaviour tests might be suggestive of antidepressant-like effects. Moreover, memantine and CGA reversed the levels of serum 5-hydroxytryptamine (5-HT), ACTH, corticotropinreleasing hormone (CRH), and dopamine (DA) that were altered in ACTH-treated rats. Based on a GC-MS metabolomic approach, significant differences in the metabolic profile were observed in ACTH-treated rats compared with the control group, as well as the M + CGA group and M + Mem group compared with the ACTH-treated group. A total of 19 metabolites were identified for the discrimination of normal rats and ACTH-treated rats, and 12 out of 19 differential metabolites were reversed with CGA intervention. Combined with pattern recognition and bioinformatics, nine perturbed metabolic pathways, including energy metabolism, neurotransmitter metabolism, and amino acid metabolism, were identified based on these metabolites. These integrative studies might give a holistic insight into the pathophysiological mechanism of the ACTH-treated depressive rat model, and also showed that CGA has antidepressant-like activities in ACTH-treated rats, providing an important drug candidate for the prevention and treatment of tricyclic anti-depressant treatment-resistant depression.

show abstract

Chlorogenic acid ameliorates endotoxin-induced liver injury by promoting mitochondrial oxidative phosphorylation

Cited by 33 publications

References 37 publications

Chlorogenic Acid Protects Against oxLDL‐Induced Oxidative Damage and Mitochondrial Dysfunction by Modulating SIRT1 in Endothelial Cells

Chlorogenic Acid Protects Against oxLDL‐Induced Oxidative Damage and Mitochondrial Dysfunction by Modulating SIRT1 in Endothelial Cells

Dietary chlorogenic acid improves growth performance of weaned pigs through maintaining antioxidant capacity and intestinal digestion and absorption function

A urinary metabolomics (GC-MS) strategy to evaluate the antidepressant-like effect of chlorogenic acid in adrenocorticotropic hormone-treated rats

Contact Info

Product

Resources

About