Chlorogenic acid administered intrathecally alleviates mechanical and cold hyperalgesia in a rat neuropathic pain model

Effect of black mulberry (Morus nigra) extract treatment on cognitive impairment and oxidative stress status of d-galactose-induced aging mice

“…Recent researches on chlorogenic acid suggest that it inhibits DNA damage and lipid peroxidation by increasing the resistance of low-density lipoprotein (Wan et al 2013) and prevents carcinogenesis by reducing DNA damage (Rakshit et al 2010;Ooi et al 2011). It has also been reported to have analgesic (Hara et al 2014), antiinflammatory (Hwang et al 2014), antidiabetic (Stefanello et al 2014), and antibacterial effects (Ozçelik et al 2011). Vanillic acid (4-hydroxy-3-methoxybenzoic acid) is a benzoic acid derivative found in plant and fruits that is being used as a preservative and antiseptic agent in cosmetic, food, and pharmaceutical industries.…”

Antinociceptive effect of intracerebroventricular administration of glycine transporter-2 inhibitor ALX1393 in rat models of inflammatory and neuropathic pain

“…Mechanical hyperalgesia was assessed in the CCI rats by measuring the withdrawal threshold of the left hind paw in response to a mechanical stimulus using an electronic von Frey esthesiometer (model 2391C; IITC Life Science, Woodland Hills, CA, USA) (Kataoka et al, 2013;Hara et al, 2014aHara et al, , 2014b. Each animal was placed on a metallic grid floor in a plastic observation chamber that provided access to the plantar surface of the hind paw.…”

“…The effect of ALX1393 on motor performance was assessed using an accelerating rotarod (model 47700; Ugo Basile) as described previously (Haranishi et al, 2010;Kataoka et al, 2013;Hara et al, 2014aHara et al, , 2014b. Normal rats were placed on a rotating drum, the speed of which increased from 4 to 40 rpm over 5 min, forcing them to walk forward to avoid falling.…”

“…Cold hyperalgesia was assessed in CCI rats using a Hot/Cold Plate (model 35100; Ugo Basile) on postoperative day 14 (Hara et al, 2014a(Hara et al, , 2014b. The rats were placed on a cold stainless steel plate maintained at 2°C, and the latency (s) to the first lifting or shaking of the CCI hind paw was measured.…”

R-phenibut binds to the α2–δ subunit of voltage-dependent calcium channels and exerts gabapentin-like anti-nociceptive effects

“…Mechanical allodynia was assessed in the CCI rats by measuring the withdrawal threshold of the left hind paw in response to a mechanical stimulus using an electronic von Frey anaesthesiometer (model 2391C; IITC Life Science Inc., Woodland Hills, CA, USA) (Hara et al, 2014). During the tests, the rats were placed on a metallic-grid floor in an individual plastic observation chamber and allowed to acclimate to the environment…”