Chlorogenic acid, a polyphenol from Prunus domestica (Mirabelle), with coupled anxiolytic and antioxidant effects

Bouayed, Jaouad; Rammal, Hassan; Dıcko, Amadou; Younos, C.; Soulimani, Rachid

doi:10.1016/j.jns.2007.06.028

Cited by 225 publications

(123 citation statements)

References 26 publications

(27 reference statements)

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“…In addition, green tea polyphenol (-)-epigallocatechin gallate (EGCG), a potent antioxidant, showed anxiolytic effects on mice with a dose-dependent relationship (Vignes et al, 2006). Anxiolytic effects have also been reported in mice with chlorogenic acid, a dietary polyphenol and antioxidant (Bouayed et al, 2007a). Inconsistent results have been reported for whortleberry extracts in rats, and vitamin E was found to increase anxiety in the same study (Kolosova et al, 2006).…”

Section: Animal Studiesmentioning

confidence: 97%

Oxidative stress in psychiatric disorders: evidence base and therapeutic implications

Berk

Dean

et al. 2008

Int. J. Neuropsychopharm.

842

569

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Oxidative stress has been implicated in the pathogenesis of diverse disease states, and may be a common pathogenic mechanism underlying many major psychiatric disorders, as the brain has comparatively greater vulnerability to oxidative damage. This review aims to examine the current evidence for the role of oxidative stress in psychiatric disorders, and its academic and clinical implications. A literature search was conducted using the Medline, Pubmed, PsycINFO, CINAHL PLUS, BIOSIS Previews, and Cochrane databases, with a time-frame extending to September 2007. The broadest data for oxidative stress mechanisms have been derived from studies conducted in schizophrenia, where evidence is available from different areas of oxidative research, including oxidative marker assays, psychopharmacology studies, and clinical trials of antioxidants. For bipolar disorder and depression, a solid foundation for oxidative stress hypotheses has been provided by biochemical, genetic, pharmacological, preclinical therapeutic studies and one clinical trial. Oxidative pathophysiology in anxiety disorders is strongly supported by animal models, and also by human biochemical data. Pilot studies have suggested efficacy of N-acetylcysteine in cocaine dependence, while early evidence is accumulating for oxidative mechanisms in autism and attention deficit hyperactivity disorder. In conclusion, multi-dimensional data support the role of oxidative stress in diverse psychiatric disorders. These data not only suggest that oxidative mechanisms may form unifying common pathogenic pathways in psychiatric disorders, but also introduce new targets for the development of therapeutic interventions.

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Section: Animal Studiesmentioning

confidence: 97%

Oxidative stress in psychiatric disorders: evidence base and therapeutic implications

Berk

Dean

et al. 2008

Int. J. Neuropsychopharm.

842

569

View full text Add to dashboard Cite

show abstract

“…Bouayed et al showed that 20 mg/kg chlorogenic acid injected intraperitoneally into mice was as potent an anxiolytic as 1 mg/kg diazepam (Valium TM ). Furthermore, its activity could be blocked by co-injection of the benzodiazepine receptor antagonist flumazenil, indicating that chlorogenic acid acts via the benzodiazepine binding site of the GABA-A receptor in vivo [5]. Thus, one might wonder why apples, coffee, prunes and cherries, all of which contain significant amounts of chlorogenic acid, are not known as anxiolytic agents.…”

Section: Modulation Of Gut Bacterial Metabolismmentioning

confidence: 99%

Improving the oral bioavailability of beneficial polyphenols through designed synergies

2009

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“…The biological properties of CGA are primarily attributed to its capacity to donate hydrogen atoms of the phenolic ring to free radicals, thus inhibiting oxidation process [7]. Research confirms that CGA, among the polyphenol compounds that occur in plants, is an important natural antioxidant [5,6,[8][9][10][11][12]. The polyphenols are scavengers of free radicals which are responsible for oxidizing biological structures, with resultant damage and pathological states of an organism.…”

Section: Introductionmentioning

confidence: 99%

Effect of chlorogenic acid on the phase transition in phospholipid and phospholipid/cholesterol membranes

Pruchnik

Bonarska-Kujawa

Kleszczyńska

2014

J Therm Anal Calorim

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Chlorogenic acid (CGA) is present in many plants, especially in green coffee, dry plums, and bilberries. It is an important bioactive polyphenol. Studies showed that CGA has an antioxidative, bacteriostatic, anticancer, antiviral, and anti-inflammatory activity. Despite great interest in this compound, its interaction with the lipid model membrane has not yet been investigated. To better understand the relationship between the biological activity of CGA and its interaction with biological membranes, the thermotropic behavior of model lipid membranes was investigated. The effect of CGA on the model lipid membrane, specifically on the lipid bilayer phase transitions, was examined by the combined methods: differential scanning calorimetry and fluorescence spectroscopy. In particular, the degree of packing order of the hydrophilic phase of the lipid bilayer was determined using the fluorimetric method with Laurdan and Prodan probes, while the fluorescence anisotropy of the hydrophobic phase with the DPH and TMA-DPH probes. The results of the study show that CGA incorporates mainly into the hydrophilic part of membrane, changing the packing order of the polar heads of lipids. No significant changes were recorded in membrane fluidity of the hydrophobic membrane region, for the fluorescence anisotropy practically did not change. One can thus infer that CGA does not penetrate deep into the hydrophobic area of the membrane.

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Chlorogenic acid, a polyphenol from Prunus domestica (Mirabelle), with coupled anxiolytic and antioxidant effects

Cited by 225 publications

References 26 publications

Oxidative stress in psychiatric disorders: evidence base and therapeutic implications

Oxidative stress in psychiatric disorders: evidence base and therapeutic implications

Improving the oral bioavailability of beneficial polyphenols through designed synergies

Effect of chlorogenic acid on the phase transition in phospholipid and phospholipid/cholesterol membranes

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