Chloroform Poisoning – A Case Report

Sridhar, N.; Krishnakishore, Chenu; Sandeep, Yanala; Sriramnaveen, P; Yadla, Manjusha; Sivakumar, V.

doi:10.3109/0886022x.2011.618920

Cited by 19 publications

(15 citation statements)

References 6 publications

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“…Some studies showed the cardiac effects of halogenated hydrocarbons . In this study, workers exposed to organic and halogenated solvents too.…”

Section: Discussionmentioning

confidence: 82%

“…2,3 Some studies showed the cardiac effects of halogenated hydrocarbons. 13 In this study, workers exposed to organic and halogenated solvents too. Another study showed the mechanisms involved in cardiac sensitization by halogenated hydrocarbons.…”

Section: Discussionmentioning

confidence: 98%

“…Some studies showed the effects of halogenated hydrocarbons on cardiac system. They demonstrated the symptoms and effects of chloroform poisoning . Researchers studied on the cardiac toxicity of the organochloride solvent trichloromethane .…”

Section: Introductionmentioning

confidence: 99%

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Electrocardiographic changes and exposure to solvents

Assadi

2017

Journal of Arrhythmia

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BackgroundOccupational exposures can cause cardiovascular disorders. Some exposures may be harmful, and exposures to chemicals such as metal welding fumes, gases, and pesticides, and stress related to physical and occupational hazard, which results in cardiovascular disorders such as arrhythmia, could be prevented. The objective of this study was to determine the electrocardiographic changes in occupational exposure to organic solvents.MethodsIt was a historical cohort study and was carried out on workers of industries. The study was carried out with flexible interview, physical examination, checklist for obtaining clinical history, and electrophysiology test. Group 1 included the workers in the production line of solvent and paint, group 2 included administrative personnel, and group 3 included workers from other industries who did not have solvent exposure. A number of participants in group 1, group 2, and group 3 were 500, 498, and 501, respectively. Electrocardiographic changes were recorded in health issues.ResultsThe frequency of arrhythmia, P wave, and QRS complex changes were highest in group 1. The risk of arrhythmia was 1.15 (1.08‐1.49), P wave change was 1.02 (1.01‐2.28) which was significant and considered as highest risk,, and QRS complex change was highest in group 1, whose relative risk was 1.53 (1.46‐1.61). ST segment and T wave changes (depression or elevation) were highest in group 1 and had no significant differences (P < .05).ConclusionWorking in solvent industry is a risk of developing arrhythmia. Exposure to chemical especially solvent agents mostly affects the cardiovascular system and is effective on electrocardiography, which must be prevented.

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“…Some studies showed the cardiac effects of halogenated hydrocarbons . In this study, workers exposed to organic and halogenated solvents too.…”

Section: Discussionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 98%

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Electrocardiographic changes and exposure to solvents

Assadi

2017

Journal of Arrhythmia

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“…Typically, the following four THMs are found as a result of chlorination: trichloromethane (TCM), bromodichloromethane (BDCM), dibromochloromethane (DBCM) and tribromomethane (TBM). These groups of compounds have been implicated in liver and kidney defects, central nervous system problems, cardiac arrhythmias and increased risk of carcinogenicity and mutagenicity as Class B carcinogens [5] [6] [7].…”

Section: Introductionmentioning

confidence: 99%

Human Health Risk Assessment of Trihalomethanes through Ingestion of Drinking Water in Shenzhen, China

Fang¹,

Guo-hong²,

Yu³

et al. 2019

OALib

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The potential health hazards of trihalomethanes (THMs) contamination in drinking water in Shenzhen were estimated. The concentrations of THMs in drinking water from 13 centralized water supply systems were determined from Jan 2015 to Dec 2016 in Shenzhen. The water environmental health risk assessment model recommended by USEPA was established based on the water monitoring data of THMs. Preliminary health risks of THMs through ingestion of drinking water were assessed. The median concentrations of THMs, TCM, DBCM, BDCM and TBM in drinking water were 37.0, 24.5, 2.3, 7.8 and 0.3 μg/L respectively. The values of carcinogenic risks for THMs, TCM, DBCM, BDCM, and TBM to the individual per year in drinking water were 4.52 × 10 −5 , 2.38 × 10 −5 , 6.07 × 10 −6 , 1.52 × 10 −5 and 7.45 × 10 −8 respectively. The values of non-carcinogenic risks for THMs, TCM, DBCM, BDCM and TBM to the individual per year in drinking water were 9.32 × 10 −2 , 7.68 × 10 −2 , 3.61 × 10 −3 , and 1.23 × 10 −2 and 4.71 × 10 −4 respectively. The health risk caused by THMs to the individual through ingestion of drinking water was in the order of TCM, BDCM, DBCM and TBM from high to low. The carcinogenic risks induced by THMs through ingestion of drinking water are acceptable with tolerable value offered by USEPA (1.0 × 10 −6 -1.0 × 10 −4 ), but reached to the tolerable value (5.0 × 10 −5 ) by International Commission on Radiological Protection (ICRP). The non-carcinogenic risk of THMs is tolerable (HI < 1).

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“…3 Chloroform-induced hepatotoxicity is usually delayed, with transaminase levels peaking at 48-72 h post-exposure and returning to normal over 4-6 weeks. [2][3][4][5] There are published case reports of toxicity occurring after ingestion or inhalational exposure, but no reports of dermal chloroform exposure resulting in systemic toxicity.…”

mentioning

confidence: 99%