Chloro 111in tetraphenylporphyrin and its possible clinical application

Cloutour, Catherine; Ducassou, D.; Pommier, Jean-Claude; Vuillemin, L

doi:10.1016/0020-708x(82)90160-0

Cited by 8 publications

(3 citation statements)

References 6 publications

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“…As well as 99m Tc, TPP has been radiolabelled with 111 In in the tetrapyrrole core to give a complex which is stable to loss of 111 In in the presence of serum proteins . Further recent studies have been carried out, with other imaging and therapeutic radioisotopes including 64 Cu, 68/67 Ga, 140 Nd and 166 Ho .…”

Section: Tetraphenylporphyrin Labellingmentioning

confidence: 99%

Radiolabelled porphyrins in nuclear medicine

Waghorn

2013

Labelled Comp Radiopharmac

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Amongst tumour-specific substances, hematoporphyrin and synthetic porphyrin derivatives have been widely investigated to identify and delineate neoplastic and malignant tissue. Whilst the tumour localization exhibited by selected porphyrin species has been exploited through photodynamic therapy, several examples of porphyrin derivatives with varied peripheral functionality have been radiolabelled with the aim of developing porphyrin-based nuclear imaging and therapeutic agents. In this review, we look at the approaches and advances in the preparation and uses of such radiolabelled agents for imaging and therapy.

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Section: Tetraphenylporphyrin Labellingmentioning

confidence: 99%

Radiolabelled porphyrins in nuclear medicine

Waghorn

2013

Labelled Comp Radiopharmac

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“…Hydrosoluble indium derivatives of macrocycles Me-1, Me-2, and Me-4, Me-1-In, Me-2-In, and Me-4-In, respectively, were purified on anion exchange resin; the corresponding indium complexes of porphyrins 3 and 5, e.g. 3-In and 5-In, were purified by chloroformic extraction, a method we perfected earlier (21), suitable for further in vivo use. The yields of metallation, determined by γ counting of 111 In radioactivity of the different pure derivatives, were between 75 and 90% except for that for compound 5-In (53%); this lower yield confirms the instability of the ester in acidic medium.…”

Section: Syntheses Of Substituted Free Base Porphyrinsmentioning

confidence: 99%

“…We selected porphyrins as 111 In chelating agents to be conjugated to antibodies for a main reason. Tetrapyrrolic macrocycles of indium belong to the class III type (20) and are stable in vivo against demetallation (21).…”

Section: Introductionmentioning

confidence: 99%

Syntheses of Functionalized Indium Porphyrins for Monoclonal Antibody Labeling

et al. 1996

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The syntheses and characterizations of five differently hydrosoluble monosubstituted aryl porphyrins are reported. Their metallation with indium-111 was achieved and provided tracers with strong specific activities. The covalent coupling between indium-111 porphyrins and BSA served as a model reaction for the definition of the best experimental coupling conditions; the transposition to the labeling of anti-CEA monoclonal antibody was realized. The conjugates exhibited an in vitro good mAb-labeling efficiency, as well as a good preservation of immunoreactivity.

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The Radiopharmaceutical Chemistry of Gallium(III) and Indium(III) for SPECT Imaging

Dilworth

Pascu

2014

The Chemistry of Molecular Imaging

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Chloro 111in tetraphenylporphyrin and its possible clinical application

Cited by 8 publications

References 6 publications

Radiolabelled porphyrins in nuclear medicine

Radiolabelled porphyrins in nuclear medicine

Syntheses of Functionalized Indium Porphyrins for Monoclonal Antibody Labeling

The Radiopharmaceutical Chemistry of Gallium(III) and Indium(III) for SPECT Imaging

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