“…The first well-designed study investigating the use of medroxyprogesterone acetate (MPA) to suppress LH surge in COS cycles was published in 2015, 9 since then many authors have tested other molecules, i.e., dydrogesterone, 10,11 micronized progesterone (MP), [12][13][14] desogestrel (DSG), [15][16][17] and chlormadinone. 18 In the context of ovarian stimulation protocols development, associating CFA to a one-pill-a-day PPOS seems to be an interesting and empathetic innovation. In this paper, we report an extremely patient-friendly PPOS protocol, using overlapping doses of CFA in desogestrel-primed regimen.…”