Chlorination by-products of bisphenol A enhanced retinoid X receptor disrupting effects

Li, Na; Jiang, Weiwei; Ma, Ming; Wang, Donghong; Wang, Zijian

doi:10.1016/j.jhazmat.2016.08.033

Cited by 24 publications

(10 citation statements)

References 42 publications

(49 reference statements)

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“…RXR agonist activities of various monohydroxylated polychlorinated biphenyls congeners (OH-PCBs), in particular tri- or tetra-chlorinated OH-PCBs were also identified recently [35]. By contrast, the plastic additive bisphenol A (BPA) and its chlorination by-products have been demonstrated to exhibit RXR antagonist activities [36]. Several statins (fluvastatin, pitavastatin) and nonsteroidal anti-inflammatory drugs ( R -etodolac, sulindac) were recognized as RXR antagonists as well [37–39].…”

Section: Resultsmentioning

confidence: 99%

Assessing the endocrine disrupting potentials and genotoxicity in environmental samples from Taiwanese rivers

Chou

Chen

et al. 2019

Genes and Environ

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BackgroundSurface waters receive a variety of organic pollutants via wastewater discharge, and sediment represents a sink for hydrophobic contaminants. In this study, we used in vitro yeast-based reporter gene assays and a Bacillus subtilis Rec-assay to examine the occurrence of endocrine disrupting activities and genotoxic potentials in samples collected from three Taiwanese rivers. Levels of 51 polycyclic aromatic hydrocarbons (PAHs) in muscles of fish captured from same rivers were also analyzed to assess in vivo pollution of PAHs.ResultsAntagonist activities for androgen receptor and retinoid X receptor (RXR) were detected in river water extracts at environmentally relevant concentrations., and sediment extracts exhibited RXR agonist, RXR antagonist, and genotoxic potentials concurrently. Σ16 PAHs in fish muscles ranged from 44.9–242.4 ng g− 1 dry weight, representing 38 to 59% of the total 51 PAHs concentrations, and methylated PAHs of low molecular weight PAHs were often detected as well.ConclusionTaiwanese river sediment samples concomitantly exhibited RXR disrupting potentials and genotoxic activities, whereas RXR agonist and antagonist activities were simultaneously detected in several dry-season sediment extracts. PAH levels in fish muscles were categorized as minimally polluted by aromatic compounds, nonetheless, the presence of methylated PAHs in muscles samples may be of concern owing to the higher toxic potentials than their parent compounds.

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Section: Resultsmentioning

confidence: 99%

Assessing the endocrine disrupting potentials and genotoxicity in environmental samples from Taiwanese rivers

Chou

Chen

et al. 2019

Genes and Environ

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“…SI Section 1 contains a description of homologous modeling and model assessment procedures. The molecular docking analysis was implemented according to our previous study . All docking experiments were performed using the Discovery Studio 4.0 software package (Accelrys Software Inc., San Diego, CA).…”

Section: Methodsmentioning

confidence: 99%

“…The molecular docking analysis was implemented according to our previous study. 38 All docking experiments were performed using the Discovery Studio 4.0 software package (Accelrys Software Inc., San Diego, CA). The protocol was generated using the CDOCKER protocol.…”

Section: Methodsmentioning

confidence: 99%

Phenanthrene-Induced Apoptosis and Its Underlying Mechanism

Hong

Qin

Chen

et al. 2017

Environ. Sci. Technol.

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Phenanthrene (Phe) is one of the most abundant low-molecular-weight polycyclic aromatic hydrocarbons (PAHs). Widespread human and aquatic organism exposure to Phe has been reported, but the toxic effects of Phe and potential mechanisms are unclear. We focused on the chronic hepatotoxicity of Phe in adult Chinese rare minnows (Gobiocypris rarus) and the underlying mechanisms. The chronic effects of exposing Chinese rare minnows to 8.9, 82.3, or 510.0 μg/L Phe for 30 days were examined by histopathological observation, TUNEL assays, caspase activity assays, and gene expression profiles. The liver lesion frequency and hepatocyte apoptosis were increased in Phe-exposed groups. Caspase 9 and caspase 3 enzyme activity in liver tissues was markedly increased. The expression of miR-17/92 cluster members was significantly increased in the 82.3 and 510.0 μg/L groups. Moreover, the response of primary hepatocytes indicated a significant decrease in the mitochondrial membrane potential (MMP) after a 48 h exposure to Phe. Interestingly, miR-18a was significantly decreased in primary hepatocytes in all treatments. Moreover, molecular docking indicated that Phe might have the same binding domain as pri-miR-18a, forming pi-pi and pi-σ interactions with heterogeneous nuclear ribonucleoprotein (hnRNP) A1. Given the above, Phe caused liver lesions and induced hepatocyte apoptosis through the intrinsic apoptosis pathway, and the interaction of Phe with hnRNP A1 contributes to the suppression of miR-18a expression and hepatocyte apoptosis.

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“…The available literature was further refined by considering whether MIEs were defined or not. Finally, 32 studies related to the endocrine system-disrupting effects of DBPs were selected in the present investigation [ 28 , 49 , 50 , 51 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 ]. As expected, most of the research on the endocrine-related detrimental effects of various DBPs were published in the last ten years even though the first publication dated back to 2003 (only seven publications from 2000 to 2009 and 25 from 2010 until now) ( Figure 1 ).…”

Section: Performance Of Publicationsmentioning

confidence: 99%

“…RXRs are key partners for the nuclear receptor signaling pathways of cell growth, differentiation, and metabolism [ 95 ]. Chlorination byproducts of BPA have been identified as RXRβ antagonists, the antagonist activities of which are much higher than that of BPA according to a yeast assay [ 63 ]. Considering that previous studies documented that BPA could exhibit several detrimental effects (e.g., endocrine-related harmful effects) on organisms [ 96 , 97 , 98 , 99 , 100 ], those results indicate that both BPA and its halogenated DBPs are potential endocrine disruptors.…”

Section: Endocrine-related Mies Of Dbpsmentioning

confidence: 99%

Research Progress of the Endocrine-Disrupting Effects of Disinfection Byproducts

Sui

Liu

Yang

2022

JoX

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Since 1974, more than 800 disinfection byproducts (DBPs) have been identified from disinfected drinking water, swimming pool water, wastewaters, etc. Some DBPs are recognized as contaminants of high environmental concern because they may induce many detrimental health (e.g., cancer, cytotoxicity, and genotoxicity) and/or ecological (e.g., acute toxicity and development toxicity on alga, crustacean, and fish) effects. However, the information on whether DBPs may elicit potential endocrine-disrupting effects in human and wildlife is scarce. It is the major objective of this paper to summarize the reported potential endocrine-disrupting effects of the identified DBPs in the view of adverse outcome pathways (AOPs). In this regard, we introduce the potential molecular initiating events (MIEs), key events (KEs), and adverse outcomes (AOs) associated with exposure to specific DBPs. The present evidence indicates that the endocrine system of organism can be perturbed by certain DBPs through some MIEs, including hormone receptor-mediated mechanisms and non-receptor-mediated mechanisms (e.g., hormone transport protein). Lastly, the gaps in our knowledge of the endocrine-disrupting effects of DBPs are highlighted, and critical directions for future studies are proposed.

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Chlorination by-products of bisphenol A enhanced retinoid X receptor disrupting effects

Cited by 24 publications

References 42 publications

Assessing the endocrine disrupting potentials and genotoxicity in environmental samples from Taiwanese rivers

Assessing the endocrine disrupting potentials and genotoxicity in environmental samples from Taiwanese rivers

Phenanthrene-Induced Apoptosis and Its Underlying Mechanism

Research Progress of the Endocrine-Disrupting Effects of Disinfection Byproducts

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