Chlorinated hydrocarbon levels in human serum: Effects of fasting and feeding

Phillips, D. L.; Pirkle, J. L.; Burse, Virlyn W.; Bernert, Jr Jt; Henderson, L. Omar; Ll, Needham

doi:10.1007/bf01055015

Cited by 791 publications

(491 citation statements)

References 16 publications

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“…Among the positive studies, one (28) reported a significant difference in DDE between breast cancer case patients and controls, as well as an almost 4-fold increase in risk comparing the highest quintile of DDE to the lowest; however, the values for serum organochlorine levels were not lipid adjusted. PCB and DDE residue levels in serum are influenced by the amount of lipid in the serum (46) and adjustment is necessary to standardize blood residue measurements.…”

Section: Discussionmentioning

confidence: 99%

Serum organochlorines and breast cancer: a case–control study among African-American women

Gatto

Longnecker

Press

et al. 2007

Cancer Causes Control

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This population-based case-control study of African-American women (355 breast cancer case patients, 327 controls) examined the association between breast cancer and circulating levels of PCBs and dichlorodiphenyldichloroethene (DDE), a metabolite of DDT. Case patients were diagnosed with invasive breast carcinoma and interviewed between June 1995 and July 1998, and control subjects were identified by random digit dialing methods. Serum levels of DDE and total PCBs were adjusted for total lipid content. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using multivariable unconditional logistic regression methods. Effect modification by tumor receptor status and cancer treatment was investigated. Breast cancer risk was not associated with increasing quintiles of lipid-adjusted PCBs or DDE (highest vs. lowest quintile adjusted for age, body mass index (BMI) and breastfeeding for DDE: OR=1.02, 95% CI=(0.61, 1.72), p-trend = 0.74; for PCBs: OR=1.01, 95% CI=(0.63, 1.63), p-trend = 0.56). Risk did not differ by strata of BMI, breastfeeding, parity, menopausal status or tumor receptor status. This study, the largest study of African-American women to date, does not support a role of DDE and total PCBs in breast cancer risk at the levels measured.

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Section: Discussionmentioning

confidence: 99%

Serum organochlorines and breast cancer: a case–control study among African-American women

Gatto

Longnecker

Press

et al. 2007

Cancer Causes Control

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“…In 2000-2001, the children underwent detailed clinical examinations at 7 years of age, and serum samples were obtained from most of them. The serum lipid content was determined from enzymatic measurements of cholesterol and triglycerides (32). On the basis of determinations of PCB in maternal serum already carried out (30,31), a subgroup of mother and child pairs was selected for the purposes of the present study.…”

Section: Methodsmentioning

confidence: 99%

Serum polychlorinated biphenyl and organochlorine insecticide concentrations in a Faroese birth cohort

et al. 2006

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The objective of this study was to assess blood concentrations of polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs), and their polychlorobiphenylol (OH-PCB) metabolites in humans with a high seafood intake. Samples were obtained from pregnant women in the Faroe Islands in 1994-1995 and from their children at 7 years of age to examine maternal transfer of the compounds to their child, age-dependent metabolism, and temporal changes. Maternal serum was dominated by 2,2',4,4'-tetrabromodiphenyl ether (BDE-47), while 2,2',4,4',5,5'-hexabromodiphenyl ether (BDE-153) prevailed in the children's serum seven years later. DecaBDE was present in both mothers and children up to 3 and 6 ng/g lipid weight, respectively. The ΣPCB concentration in the children averaged about 60% of the concentrations in their mothers, with median levels for both above 1 µg/g lipid weight and with similar PCB congener patterns. ΣOH-PCB serum concentrations from the mothers and their children showed ranges of 1.8-36 ng/g wet weight (w.w.) and 0.49-22 ng/g w.w., respectively, with all OH-PCB congener concentrations being lower in the children, except for 2,3,3',4',5-pentachloro-4-biphenylol (4-OH-CB107). Children at 7 years of age are exposed to PCBs at levels only slightly below those of their mothers, and the increased 4-OH-CB-107 concentrations in children could be due to age-related differences in PCB metabolism. The PBDE concentrations were similar in both mothers and their children. The main persistent organic pollutant concentrations in the children are most probably due to other environmental exposure than maternal transfer.

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“…LDLc was calculated using the formula (9) LDL c = Total cholesterol -(HDL c+ TG/5). Serum total lipid content was calculated as recommended by Phillips and colleagues (10). Total serum lipid (mg/dl) = 2.27 x serum cholesterol (mg/dl) + serum tdglyceddes (mg/ dl) + 0.623.…”

Section: Methodsmentioning

confidence: 99%

Vitamin E supplementation on biochemical changes observed in agricultural field workers exposed to different classes of pesticides

Prakasam

Sethupathy

2001

Indian J Clin Biochem

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A total of 41 healthy male pesticide sprayers exposed to different clases of pesticides for 3-5 years were compared with 21 controls matched for age and economic status with respect to free radical generation, lipid peroxidation, antioxidant status, cholesterol, lipoprotein status and haematological profile. Plasma lipid peroxidation was estimated in the form of thiobarbituric acid reactive substances (TBARS) produced. Significant increase in TBARS was observed in sprayers population when compared with control subjects and the level of TBARS increased with increase in the duration of exposure. The levels of antioxidants such as glutathJone (GSH) were significantly depleted, whereas those of superoxide dismutase (SOD) were remarkably increased than control population. Significant reduction in total cholesetrol, alteration in lipoprotein fractions and nonsignificant changes in hematological parameters were observed. These results suggested that exposure to pesticidal residual drift augments the free radical generation, and lipid peroxidation. Decline in non-enzymatic antioxidant and elevation of enzymatic antioxidant were observed. Supplementation of r for 45 days resulted in the partial restoration of these biochemical changes produced by pesticides.

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Chlorinated hydrocarbon levels in human serum: Effects of fasting and feeding

Cited by 791 publications

References 16 publications

Serum organochlorines and breast cancer: a case–control study among African-American women

Serum organochlorines and breast cancer: a case–control study among African-American women

Serum polychlorinated biphenyl and organochlorine insecticide concentrations in a Faroese birth cohort

Vitamin E supplementation on biochemical changes observed in agricultural field workers exposed to different classes of pesticides

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