Chlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyl profiles of workers with trichlorophenol and pentachlorophenol exposures

Collins, James J.; Bodner, Kenneth M.; Haidar, Salma; Wilken, Michael; Burns, Carol J.; Lamparski, L.L.; Budinsky, Robert A.; Martin, Greg D.; Carson, Michael L.

doi:10.1016/j.chemosphere.2007.12.034

Cited by 11 publications

(11 citation statements)

References 27 publications

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“…Maroni et al [105] reported the hepatotoxicity of VCM and other studies have shown the capacity of VCM to Group 1 [76] TCE 79-01-6 Dry cleaning; paint stripping; metal degreasing; production of chlorinated chemical compounds; shoe manufacturing; aircraft/aerospace, electronics and printing industry [125,127] Group 1 [129] PCE 127-18-4 Dry cleaning; textile processing; metal degreasing [138] Group 2A [129] DDT 50-29-3 Farming industry [141,145] Group 2B [148] N-nitrosamines 35576-91-1 Plastic, rubber and pharmacological manufacturing; farming industry; metalworking; electrical component production and use; gasoline and lubricant additives, production and use [159][160][161][162][163][164][165] Group [160,161] TCDD 1746-01-6 Waste management; paper mill; timber manufacturing; iron and steel manufacturing; electric power industry [175,179] Group 1 [76] PeCDF 57117-31-4 Cement and metalworking industry; chemical manufacturing [171,172,175] Group 1 [76] PCB 1336-36-3 Electrical industry, plastic and chemical industry; maintenance/repair technicians of PCB devices [175,[186][187][188][189][190] 1 Group [76,207] PBB Electronics recycling industry; maintenance/repair technicians of PBB devices [209][210][211][212] Group 2A [207] Chloral 75-87-6 Insecticides and herbicide production; p...…”

Section: Organic Solventsmentioning

confidence: 99%

“…The National Institute for Occupational Safety and Health (NIOSH) has classified TCDD as an occupational carcinogen that can cause space-occupying liver lesions, both non-neoplastic and neoplastic, such as in HCC [177][178][179][180][181] . Many studies have indicated that the carcinogenic capacity of TCDD may be due to the interaction between TCDD and the aryl hydrocarbon receptor (AhR).…”

Section: Dioxins and Dioxin-like Compoundsmentioning

confidence: 99%

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Hepatocellular carcinoma and the risk of occupational exposure

Rapisarda

Loreto

Malaguarnera

et al. 2016

WJH

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Hepatocellular carcinoma (HCC) is the most common type of liver cancer. The main risk factors for HCC are alcoholism, hepatitis B virus, hepatitis C virus, nonalcoholic steatohepatitis, obesity, type 2 diabetes, cirrhosis, aflatoxin, hemochromatosis, Wilson's disease and hemophilia. Occupational exposure to chemicals is another risk factor for HCC. Often the relationship between occupational risk and HCC is unclear and the reports are fragmented and inconsistent. This review aims to summarize the current knowledge regarding the association of infective and non-infective occupational risk exposure and HCC in order to encourage further research and draw attention to this global occupational public health problem. Core tip: Hepatocellular carcinoma (HCC) is the fifth most common human cancer. This review summarizes current knowledge regarding the occupational risk factors of HCC. In particular, we underline not only the infective but also non-infective occupational risk exposure, including chemical agents and toxic metabolites which are a major cause of liver damage.

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Section: Organic Solventsmentioning

confidence: 99%

Section: Dioxins and Dioxin-like Compoundsmentioning

confidence: 99%

Hepatocellular carcinoma and the risk of occupational exposure

Rapisarda

Loreto

Malaguarnera

et al. 2016

WJH

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“…Oral administration of PCB 126 resulted in a notably higher incidence of HCA and CLC (32,226). The most important epidemiological studies of TCDD carcinogenicity were cohort studies of herbicide producers and users in the US, the Netherlands and Germany, and of the residents of a contaminated area at Seveso, Italy (218,230–233). All found an increased risk for lung cancer, soft tissue sarcoma and non-Hodgkin lymphoma, primarily in the more heavily exposed sub-groups (135,218).…”

Section: Resultsmentioning

confidence: 99%

Non-infective occupational risk factors for hepatocellular carcinoma: A review

Ledda

Loreto

Zammit

et al. 2016

Molecular Medicine Reports

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Liver cancer is the second leading worldwide cause of cancer-associated mortalities. Hepatocellular carcinoma, which accounts for the majority of liver tumors, ranks fifth among types of human cancer. Well-established risk factors for liver cancer include the hepatitis B and C viruses, aflatoxins, alcohol consumption, and oral contraceptives. Tobacco smoking, androgenic steroids, and diabetes mellitus are suspected risk factors. Current knowledge regarding non-infective occupational risk factors for liver cancer is inconclusive. The relevance of liver disorders to occupational medicine lies in the fact that the majority of chemicals are metabolized in the liver, and toxic metabolites generated via metabolism are the predominant cause of liver damage. However, their non-specific clinical manifestations that are similar in a number of liver diseases make diagnosis difficult. Furthermore, concomitant conditions, such as viral hepatitis and alcohol or drug abuse, may mask liver disorders that result from occupational hepatotoxic agents and block the demonstration of an occupational cause. The identification of environmental agents that result in human cancer is a long and often difficult process. The purpose of the present review is to summarize current knowledge regarding the association of non-infective occupational risk exposure and HCC, to encourage further research and draw attention to this global occupational public health problem.

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“…These workshops were initially characterized by a high prevalence of chloracne, testifying to dioxin contamination. A recent study found that serum dioxin levels were 2 to 3 times higher in former workers in pentachlorophenol production, 20 years after production had been stopped, than in the general population [Collins et al, 2008].…”

Section: Introductionmentioning

confidence: 99%