Chloride sensitive probes for biological applications

Geddes, Chris D.; Apperson, Kathleen; Karolin, Jan; Birch, David J. S.

doi:10.1016/s0143-7208(00)00108-x

Cited by 16 publications

(12 citation statements)

References 8 publications

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“…The change in the electronic properties and the geometry at the boron atom induces the fluorescence spectral changes of the probes. It is well-known that the quinine/quinoline compounds exhibit high quantum yields in acidic media, from the corresponding quaternized salt [46,47]. Similarly here, the boronic acid probes are more fluorescent in acidic solutions.…”

Section: Photophysical Characterization Of the Quinolinium Probesmentioning

confidence: 54%

“…Table I shows the quantum yield values for the probes in water, obtained from a spectral comparison with N -(3-Sulfopropyl)-6-methoxyquinolinium [(SPQ) ( f = 0.53 in water [46])], where we can see that the BMOQBA probes have significantly larger quantum yields as compared to the BMQBA probes. Another reference compound, N -methyl-6-methylquinolinium bromide (MMQ) previously published by the authors [47] exhibits very similar spectral properties, except for a noticeable quantum yield and mean lifetime difference, approximately 10-fold higher than its methyl quinolinium counterpart, namely BMQBA. This indicates an interaction between the phenyl ring and quinolinium moiety for the BMQBA and BMQ probes, Table I, which is not present, or present to a much lesser extent, for the BMOQBA probes.…”

Section: Discussionmentioning

confidence: 99%

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Ophthalmic Glucose Monitoring Using Disposable Contact Lenses—A Review

Badugu

Lakowicz

Geddes

2004

Journal of Fluorescence

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We have developed a range of disposable and colorless tear glucose sensing contact lenses, using offthe-shelf lenses embedded with new water soluble, highly fluorescent and glucose sensitive boronic acid containing fluorophores. The new lenses are readily able to track tear glucose levels and therefore blood glucose levels, which are ideally suited for potential use by diabetics. The fluorescence responses from the lenses can be monitored using simple excitation and emission detection devices. The novelty of our approach is two fold. Firstly, the notion of sensing extremely low glucose concentrations in tears, which track blood levels, by our contact lens approach, and secondly, the unique compatibility of our new glucose signaling probes with the internal mildly acidic contact lens environment. The new lenses are therefore ideal for the non-invasive and continuous monitoring of tear glucose, with about 15-min response time, and a measured shelf life in excess of 3 months. In this review article, we show that fluorescence based signaling using plastic disposable lenses, which have already been industrially optimized with regard to vision correction and oxygen/analyte permeability etc, may a notable alternative to invasive and random finger pricking, the most widely used glucose monitoring technology by diabetics.

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Section: Photophysical Characterization Of the Quinolinium Probesmentioning

confidence: 54%

Section: Discussionmentioning

confidence: 99%

Ophthalmic Glucose Monitoring Using Disposable Contact Lenses—A Review

Badugu

Lakowicz

Geddes

2004

Journal of Fluorescence

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show abstract

“…The change in the electronic properties and the geometry at the boron atom induces the fluorescence spectral changes of the probes. It is well-known that the quinine/quinoline compounds exhibit high quantum yields in acidic media, from the corresponding quatemized salt [46,47]. Similarly here, the boronic acid probes are more fluorescent in acidic solutions.…”

Section: Photophysical Characterization Of the Quinolinium Probesmentioning

confidence: 56%

“…Table 15.2 shows the quantum yield values for the probes in water, obtained from a spectral comparison with iV-(3-sulfopropyl)-6-methoxyquinolinium [ (SPQ) (Of = 0.53 in water [46])], where we can see that the BMOQBA probes have significantly higher quantum yields as compared to the BMQBA probes. Another reference compound, A^-methyl-6-methylquinolinium bromide (MMQ) previously published by the authors [47] exhibits very similar spectral properties to that of BMQ and BMQBA probes, except for a noticeable quantum yield and mean lifetime difference, approximately 10-fold higher than its methyl quinolinium counterpart, namely BMQBA. This indicates an interaction between the phenyl ring and methylquinolinium moiety of the BMQBA and BMQ probes.…”

Section: Glucose Sensing Probes Based On the Quiniloinium Moietymentioning

confidence: 97%

Ophthalmic Glucose Monitoring Using Disposable Contact Lenses

Badugu¹,

Lakowicz²,

Geddes³

Reviews in Fluorescence

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“…Secondly, it is well known that quinolinium derivatives exhibit higher fluorescence intensities over the parent quinolines. This is because, in the parent quinolines, the low-lying triplet n-7i* state deactivates the excited fluorophores, considerably [55][56][57]. Upon quartemization, i.e.…”

Section: Signaling Mechanism In Quinolinium Probesmentioning

confidence: 99%