Chloride Gradient Is Involved in Ammonium Influx in Human Erythrocytes
Julia Sudnitsyna,
Tamara O. Ruzhnikova,
Mikhail A. Panteleev
et al.
Abstract:The ammonia/ammonium (NH3/NH4+, AM) concentration in human erythrocytes (RBCs) is significantly higher than in plasma. Two main possible mechanisms for AM transport, including simple and facilitated diffusion, are described; however, the driving force for AM transport is not yet fully characterized. Since the erythroid ammonium channel RhAG forms a structural unit with anion exchanger 1 (eAE1) within the ankyrin core complex, we hypothesized the involvement of eAE1 in AM transport. To evaluate the functional i… Show more
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