Chlorhexidine versus routine bathing to prevent multidrug-resistant organisms and all-cause bloodstream infections in general medical and surgical units (ABATE Infection trial): a cluster-randomised trial

Abstract

Contributors SSH contributed to study design, study conduct, data analysis, data interpretation and manuscript drafting. RP contributed to study design, study conduct, data interpretation, and manuscript review. KK contributed to study design, data analysis, data interpretation, analytic plan draft, and manuscript review. ES, JM, MH, and RAW contributed to study conduct, data interpretation, and manuscript review. JH, LH, and AG contributed to study conduct, data collection, and manuscript review. KH, LS, REK, JL, MHC, JAJ, and JBP contributed to study conduct and manuscript review. CS, TF, LP, and JS contributed to data collection and manuscript review. MVM contributed to data analysis and manuscript review. TRA contributed to data analysis, data interpretation, and manuscript review.Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.Disclosures: Sage Products and Molnlycke contributed antiseptic Chlorhexidine product to this trial. Investigators are also conducting other studies in which contributed antiseptic product is provided to participating hospitals and nursing homes from Stryker (Sage

Managing and preventing vascular catheter infections: A position paper of the international society for infectious diseases

“…Daily chlorhexidine bathing has been demonstrated to reduce CLABSI rates among adult and children in intensive care units (Frost et al, 2016;Dicks et al, 2016). Huang et al (2019), despite a lack of overall protective effect in non-ICU patients, found reductions in MRSA and VRE infections in patients with medical devices. 2.…”

Implementing daily chlorhexidine gluconate treatment for the prevention of healthcare-associated infections in non-intensive care settings: A multiple case analysis

“…Daily bathing or treatment of hospitalized patients with the broad-spectrum antiseptic chlorhexidine gluconate (CHG) has been shown to reduce healthcare-associated bloodstream infections [5][6][7] and colonization by multidrug resistant organisms, particularly in the intensive care unit (ICU) [5]. Extending this treatment outside the ICU may have benefit as well, particularly for patients with medical devices, such as central lines, midline catheters and lumbar drains [8]. However, there is considerable variation in the implementation of CHG treatment when deployed outside the ICU.…”

Nasal decolonization of Staphylococcus aureus and the risk of surgical site infection after surgery: a meta-analysis

“…It remains one of the most common drug-resistant pathogens that causes infection in hospitalized patients 1,2 . Investments in infection reduction have been posed in intensive care units, which has been de ned as an "epicenter" of nosocomial infections, by measurements of skin decolonization involving daily chlorhexidine bathing 3 . The practice was adopted because of evidence that universal decolonization reduces device-associated bacteremia, all-cause bacteremia, and multidrugresistant organisms 3,4 .…”

“…Investments in infection reduction have been posed in intensive care units, which has been de ned as an "epicenter" of nosocomial infections, by measurements of skin decolonization involving daily chlorhexidine bathing 3 . The practice was adopted because of evidence that universal decolonization reduces device-associated bacteremia, all-cause bacteremia, and multidrugresistant organisms 3,4 . However, the nasal carriage is also unavoidable for endogenous infections and for transmission to other individuals, as the colonization of extra nasal sites often originates from the nasal reservoir 5 .…”