Chlorhexidine-loaded polysulfobetaine/keratin hydrogels with antioxidant and antibacterial activity for infected wound healing

Multifunctional type lll recombinant human collagen incorporated sodium alginate hydrogel with sustained release of extra cellular vehicles for wound healing multimodal therapy in diabetic mice

“…Raising the concentration of cross-linkers has the expected effect of reducing swelling ratios. Hydrogel is a great option for wound dressings because even when crosslinked with 5%, its swelling ratio is 497% [ 20 ].

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“…One of the most important factors in diabetic wound healing is oxidative stress. Overproduction of reactive oxygen species (ROS) results in harm to cells and tissues and delayed wound healing when the body's free radical production and antioxidant levels are out of whack [ 20 ]. So, lowering ROS levels via the antioxidant system can lessen damage caused by oxidative stress, which in turn improves healing [ 21 ].…”

Stimuli-responsive peptide hydrogels for biomedical applications

“…Moreover, Shang et al synthesized a covalently crosslinked dual-network hydrogel loaded with chlorhexidine (CHX) through free radical polymerization of sulfobetaine and oxidative cross-linking of reduced keratin. 149 The introduced keratin and CHX imparted cell compatibility and antioxidant properties to the hydrogel. Interestingly, the freeze-dried hydrogel could be milled into a powder, sprinkled onto irregular wound beds, and subsequently rehydrated by wound fluid to reform the gel in situ .…”

Novel luminescent hierarchical porous hydrogels with a three-dimensional interconnected network structure from feather keratin crosslinking reaction

“…These hydrogels exhibited acidity, glutathione, and trypsin triple-responsive release behaviors, resulting in the accelerated release of CHX under wound microenvironments. 19 The synthesis of these keratin materials requires the hydrolysis of natural keratin wastes and the addition of crosslinking agent. Here, we present the design and synthesis of six eco-friendly luminescent keratin-hydrogels using a one-pot method.…”