Abstract:Drug release profiles of novel alkane-crosslinked nanocellulose hydrogels were investigated. The common antiseptic compound chlorhexidine digluconate (CHX-DG) was loaded into the nanocellulose hydrogels, and the release kinetics were studied under two different release regimes. The hydrogels were effective at absorbing more than their dry weights of the antiseptic and retaining it during diffusion testing, with more than 60% of the drug retained in the hydrogels. Antimicrobial tests showed sustained antimicrob… Show more
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