Chlorfenapyr: A pyrrole insecticide for the control of pyrethroid or DDT resistant Anopheles gambiae (Diptera: Culicidae) mosquitoes

N’Guessan, Raphaël; Boko, Pélagie; Odjo, Abibatou; Akogbéto, Martin; Yates, Alison; Rowland, Mark

doi:10.1016/j.actatropica.2007.03.003

Cited by 88 publications

(92 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A range of nonpyrethroid public health insecticides was tested on electrostatic netting, including bendiocarb (a carbamate) and azamethiphos (an organophosphate). Chlorfenapyr (a pyrrole), which is a relatively new class of insecticide for malaria vector control, was evaluated also (34). With standard 3-min cone assays, all tested insecticides induced 100% mortality in Cx.…”

Section: Resultsmentioning

confidence: 99%

Electrostatic coating enhances bioavailability of insecticides and breaks pyrethroid resistance in mosquitoes

Andriessen

Snetselaar

Suer

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Insecticide resistance poses a significant and increasing threat to the control of malaria and other mosquito-borne diseases. We present a novel method of insecticide application based on netting treated with an electrostatic coating that binds insecticidal particles through polarity. Electrostatic netting can hold small amounts of insecticides effectively and results in enhanced bioavailability upon contact by the insect. Six pyrethroid-resistant Anopheles mosquito strains from across Africa were exposed to similar concentrations of deltamethrin on electrostatic netting or a standard longlasting deltamethrin-coated bednet (PermaNet 2.0). Standard WHO exposure bioassays showed that electrostatic netting induced significantly higher mortality rates than the PermaNet, thereby effectively breaking mosquito resistance. Electrostatic netting also induced high mortality in resistant mosquito strains when a 15-fold lower dose of deltamethrin was applied and when the exposure time was reduced to only 5 s. Because different types of particles adhere to electrostatic netting, it is also possible to apply nonpyrethroid insecticides. Three insecticide classes were effective against strains of Aedes and Culex mosquitoes, demonstrating that electrostatic netting can be used to deploy a wide range of active insecticides against all major groups of disease-transmitting mosquitoes. Promising applications include the use of electrostatic coating on walls or eave curtains and in trapping/ contamination devices. We conclude that application of electrostatically adhered particles boosts the efficacy of WHO-recommended insecticides even against resistant mosquitoes. This innovative technique has potential to support the use of unconventional insecticide classes or combinations thereof, potentially offering a significant step forward in managing insecticide resistance in vector-control operations.electrostatic coating | insecticide | resistance management | mosquito | malaria

show abstract

Section: Resultsmentioning

confidence: 99%

Electrostatic coating enhances bioavailability of insecticides and breaks pyrethroid resistance in mosquitoes

Andriessen

Snetselaar

Suer

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

show abstract

“…Against termites, the effectiveness of chlorfenapyr as a barrier treatment is largely attributed to its non-repellent toxic activity and to its long half-life which is about one year in soil (Rust & Saran 2006). Against mosquitoes, N'Guessan et al (2007b) observed that chlorfenapyr is non-irritant at low dosages but stimulates take-offs at higher dosages. Numbers in the same row sharing a letter superscript do not differ significantly.…”

Section: Discussionmentioning

confidence: 99%

“…Owing to this, chlorfenapyr seems unlikely to show cross-resistance to conventional neurotoxic insecticides. Laboratory tests with a discriminating concentration of chlorfenapyr resulted in full mortality in the susceptible, kdr and Ace-1 R strains of A. gambiae sensu stricto, indicating no cross-resistance to these pyrethroid and organophosphate resistance mechanisms (N'Guessan et al 2007b). N'Guessan observed that 100 and 250 mg ⁄ m 2 dosages of chlorfenapyr had significantly better impact on the kdr strain than field rates of permethrin (500 mg ⁄ m 2 ), deltamethrin (25 mg ⁄ m 2 ) or lambdacyalothrin (18 mg ⁄ m 2 ) under similar conditions in tunnel tests (WHO 2006).…”

Section: Introductionmentioning

confidence: 97%

Experimental hut evaluation of the pyrrole insecticide chlorfenapyr on bed nets for the control of Anopheles arabiensis and Culex quinquefasciatus

Mosha

Lyimo

Oxborough

et al. 2008

Tropical Med Int Health

Self Cite

View full text Add to dashboard Cite

Summaryobjective To determine the efficacy of chlorfenapyr against Anopheles arabiensis and Culex quinquefasciatus in East Africa and to identify effective dosages for net treatment in comparison with the commonly used pyrethroid deltamethrin.methods Chlorfenapyr was evaluated on bed nets in experimental huts against A. arabiensis and C. quinquefasciatus in Northern Tanzania, at application rates of 100-500 mg ⁄ m 2 .results In experimental huts, mortality rates in A. arabiensis were high (46.0-63.9%) for all dosages of chlorfenapyr and were similar to that of deltamethrin-treated nets. Mortality rates in C. quinquefasciatus were higher for chlorfenapyr than for deltamethrin. Despite a reputation for being slow acting, >90% of insecticide-induced mortality in laboratory tunnel tests and experimental huts occurred within 24 h, and the speed of killing was no slower than for deltamethrin-treated nets.conclusions Chlorfenapyr induced low irritability and knockdown, which explains the relatively small reduction in blood-feeding rate. Combining chlorfenapyr with a more excito-repellent pyrethroid on bed nets for improved personal protection, control of pyrethroid-resistant mosquitoes and pyrethroid resistance management would be advantageous.

show abstract

“…[IUPAC name: 4-Bromo-2-(4-chlorophenyl)-1-ethoxymethyl-5-(trifluoromethyl) pyrrole-3-carbonitrile] is a pyrrole and broad-spectrum insecticide-miticide, registered at present in 19 countries for the control of various species of insects and mites (Cao et al 2005a;N'Guessan et al 2007), including those resistant to (1) carbamate, organophosphate and pyrethroid insecticides and (2) chitin-synthesis inhibitors, in cotton, vegetables, citrus, and soy beans. Chlorfenapyr is actually a pro-insecticide that is metabolized to an active metabolite in the midgut of the insects and mites.…”

Section: Introductionmentioning

confidence: 99%

Effects of nanopesticide chlorfenapyr on mice

WanJun

Shi

Sai-Yan

et al. 2010

Toxicological & Environmental Chemistry

View full text Add to dashboard Cite

The effects of chlorfenapyr nano preparation on mice were examined. The animals were administered with different doses of 4. 84, 9.68, or 19.36 mg kg À1 of chlorfenapyr common preparation or nano preparation intraperitoneally (IP). Micronucleus (MN) test and comet assay (CA) experiments revealed that at the same dose, similar DNA damage in the peripheral blood lymphocytes of the mouse and chromosome damage in bone marrow cells of the mouse occurred with chlorfenapyr nano preparation; however, the severity of these effects was less than that found in common preparation. It is noteworthy that there were no differences in apoptotic ratio and live cell percentage in the liver cells of the mouse between these two pesticide formulations using flow cytometry. Data indicate that chlorfenapyr nanoformulation is less toxic to mouse cells than the common formulation.

show abstract

Chlorfenapyr: A pyrrole insecticide for the control of pyrethroid or DDT resistant Anopheles gambiae (Diptera: Culicidae) mosquitoes

Cited by 88 publications

References 32 publications

Electrostatic coating enhances bioavailability of insecticides and breaks pyrethroid resistance in mosquitoes

Electrostatic coating enhances bioavailability of insecticides and breaks pyrethroid resistance in mosquitoes

Experimental hut evaluation of the pyrrole insecticide chlorfenapyr on bed nets for the control of Anopheles arabiensis and Culex quinquefasciatus

Effects of nanopesticide chlorfenapyr on mice

Contact Info

Product

Resources

About