Chlordiazepoxide and dizocilpine, but not morphine, selectively impair acquisition under a novel repeated-acquisition and performance task in rats

Pitts, Raymond C.; Buda, D; Keith, Julian R.; Cerutti, Daniel T.; Galizio, Mark

doi:10.1007/s00213-006-0538-5

Cited by 13 publications

(11 citation statements)

References 24 publications

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“…For example, Keller et al (2000) has shown excellent visual discrimination in rats using a similar apparatus to the one used here. More importantly for the present study, Pitts et al (2006) found selective effects of certain drugs (e.g., chlordiazepoxide) in a RAP procedure identical to the one used here. In the present study, the effects of MA, MPD and MDMA were determined.…”

Section: Introductionsupporting

confidence: 70%

Effects of MDMA, methamphetamine and methylphenidate on repeated acquisition and performance in rats

Galizio

McKinney

Cerutti

et al. 2009

Pharmacology Biochemistry and Behavior

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Repeated-acquisition procedures that include performance controls for effects not specific to acquisition permit the assessment of drug effects on learning on a within-subject, within-session basis. Despite the advantages of this methodology, few studies have examined effects of psychomotor stimulants on repeated acquisition in rodents. The purpose of the present study was to investigate the effects of methylenedioxymethamphetamine (MDMA, 0.3-10 mg/kg), methamphetamine (MA, 0.1-3 mg/kg) and methylphenidate (MPD,1-17 mg/kg) using repeated-acquisition procedures with performance controls in rats using a touch-screen apparatus. Rats were presented a 2 × 3 array of stimuli using a computer touch-screen and nose-pokes to target locations within the array were reinforced. In the acquisition component, the correct location changed across sessions, whereas during the performance component, the correct location was constant across sessions. All three drugs reduced accuracy of responding to target locations in a dose-dependent fashion. None of the compounds enhanced learning at any dose. MPD and MA produced significant disruptions of acquisition accuracy only at doses that also disrupted performance, but the 3 mg/kg dose of MDMA impaired acquisition of target responding without affecting performance. The selective impairment of acquisition found in the present study adds to the evidence of learning and memory disruption produced by acute MDMA administration and raise questions about the mechanisms for these actions.

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Section: Introductionsupporting

confidence: 70%

Effects of MDMA, methamphetamine and methylphenidate on repeated acquisition and performance in rats

Galizio

McKinney

Cerutti

et al. 2009

Pharmacology Biochemistry and Behavior

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“…Dizocilpine can induce a good model of cognitive impairment with up to 0.1mg/kg subcutaneous doses without causing motor issues or intoxication (van der Staay et al, 2011). Of specific interest to our radial-arm repeated acquisition task, dizocilpine has been shown to increase errors on a radial-arm task (Levin et al, 1998; Ward et al, 1990) as well as impair acquisition of behavior in a novel repeated acquisition nose poke test (Pitts et al, 2006). Nicotine was previously shown to attenuate the impairment caused by this NMDA antagonist in a radial-arm maze task (Levin et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

Decreasing nicotinic receptor activity and the spatial learning impairment caused by the NMDA glutamate antagonist dizocilpine in rats

Burke

Heshmati

Kholdebarin

et al. 2014

European Journal of Pharmacology

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Nicotinic systems have been shown by a variety of studies to be involved in cognitive function. Nicotinic receptors have an inherent property to become desensitized after activation. The relative role of nicotinic receptor activation vs. net receptor inactivation by desensitization in the cognitive effects of nicotinic drugs remains to be fully understood. In these studies, we tested the effects of the α7 nicotinic receptor antagonist methyllycaconitine (MLA), the α4β2 nicotinic receptor antagonist dihydro-β-erythroidine (DHβE), the nonspecific nicotinic channel blocker mecamylamine and the α4β2 nicotinic receptor desensitizing agent sazetidine-A on learning in a repeated acquisition test. Adult female Sprague-Dawley rats were trained on a repeated acquisition learning procedure in an 8-arm radial maze. MLA (1–4 mg/kg), DHβE (1–4 mg/kg), mecamylamine (0.125–0.5 mg/kg) or sazetidine-A (1 and 3 mg/kg) were administered in four different studies either alone or together with the NMDA glutamate antagonist dizocilpine (0.05 and 0.10 mg/kg). MLA significantly counteracted the learning impairment caused by dizocilpine. The overall choice accuracy impairment caused by dizocilpine was significantly attenuated by co-administration of DHβE. Low doses of the non-specific nicotinic antagonist mecamylamine also reduced dizocilpine-induced repeated acquisition impairment. Sazetidine-A reversed the accuracy impairment caused by dizocilpine. These studies provide evidence that a net decrease in nicotinic receptor activity can improve learning by attenuating learning impairment induced by NMDA glutamate blockade. This adds to evidence in cognitive tests that nicotinic antagonists can improve cognitive function. Further research characterizing the efficacy and mechanisms underlying nicotinic antagonist and desensitization induced cognitive improvement is warranted.

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“…There is a possibility that morphine interfered with the rat’s memory of this relationship, thus confounding interpretation of the data. However, it has been reported that morphine at 5.6mg/kg did not impair performance in a nose-poke repeated performance test (Pitts et al, 2006), and pre-test subcutaneous administration of 5 mg/kg morphine had no effect on memory retrieval in a step-down avoidance test (Lu et al, 2010). Further, post-training administration of 2.5 mg/kg morphine did not significantly reduce step-through latency in a step-through passive avoidance study (Khajehpour et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

DAMGO in the central amygdala alleviates the affective dimension of pain in a rat model of inflammatory hyperalgesia

Zhang

et al. 2013

Neuroscience

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Pain has sensory-discriminative and emotional-affective dimensions. Recent studies show that the affective component can be assessed with a conditioned place avoidance (CPA) test. We hypothesized that systemic morphine before a post-conditioning test would more potently attenuate the affective aspect compared to the sensory component and that DAMGO, a μ-selective opioid receptor agonist, injected into the central nucleus of the amygdala (CeA) would reduce established CPA. A rat model of inflammatory pain, produced by a complete Freund adjuvant (CFA) injection into the hind paw, was combined with a CPA test. Three experiments were performed on adult male Sprague-Dawley rats. Systemic morphine (0.5 or 1.0 mg/kg) in Experiment 1, intrathecal (i.t.) morphine (2.5 μg/rat) in Experiment 2, and intra-CeA DAMGO (7.7-15.4 ng/0.4μl) in Experiment 3 were given to CFA-injected rats (n=6-8/group) prior to a post-conditioning test. Saline-injected rats were used as control. Time spent in a pain-paired compartment was recorded twice, before conditioning and after a post-conditioning test. Paw withdrawal latency (PWL) to a noxious thermal stimulus was measured before experiment at day −1 and after the post-conditioning test; hyperalgesia was defined as a decrease in PWL. The data showed that CFA-injected rats had significantly negative CPA compared to those of saline-injected rats (P<0.05). Low dosage systemic morphine significantly (P<0.05) reduced CFA-induced CPA but had no effect on PWL. I.t. morphine did not inhibit the display of CPA but significantly increased PWL, suppressing hyperalgesia (P<0.05). Intra-CeA DAMGO significantly inhibited the display of CPA compared to saline (P<0.05) but had no effect on PWL. The data demonstrates that morphine attenuates the affective component more powerfully than it does the sensory and suggests that the sensory and the emotional-affective dimensions are underpinned by different mechanisms.

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Chlordiazepoxide and dizocilpine, but not morphine, selectively impair acquisition under a novel repeated-acquisition and performance task in rats

Cited by 13 publications

References 24 publications

Effects of MDMA, methamphetamine and methylphenidate on repeated acquisition and performance in rats

Effects of MDMA, methamphetamine and methylphenidate on repeated acquisition and performance in rats

Decreasing nicotinic receptor activity and the spatial learning impairment caused by the NMDA glutamate antagonist dizocilpine in rats

DAMGO in the central amygdala alleviates the affective dimension of pain in a rat model of inflammatory hyperalgesia

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