Chlordiazepoxide and diazepam induced mouse killing by rats

Leaf, Russell C.; Wnek, D.J.; Corcia, R. M.; Lamon, Stacy

doi:10.1007/bf00421178

Cited by 43 publications

(3 citation statements)

References 13 publications

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“…Especially low doses may increase aggression, but only under certain circumstances (see Mos and Olivier 1987). With the exception of the studies of Fox and coworkers on intergroup aggression in mice (1974 and references therein) and the induction of mousekilling (Leaf et al 1975), there have been no systematic studies comparing the pro-aggressive capabilities of different benzodiazepines. The present report compares four different benzodiazepines with respect to their pro-aggressive action by using quantitative and comparative ethopharmacological techniques.…”

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confidence: 97%

Quantitative and comparative analyses of pro-aggressive actions of benzodiazepines in maternal aggression of rats

Olivier

1989

Psychopharmacology

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The pro-aggressive effects of low doses of benzodiazepines on maternal aggression in rats were studied. Chlordiazepoxide, diazepam, oxazepam and alprazolam produced bell-shaped dose-response curves, with increased aggression at low doses. Only alprazolam significantly reduced aggression at higher doses. A comparison of the drug effects on different aggressive elements revealed that chlordiazepoxide and oxazepam increased the frequency of more elements of the aggressive repertoire than diazepam or alprazolam. Thus, although all benzodiazepine receptor agonists increased aggression, there were significant quantitative differences in their effects.

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confidence: 97%

Quantitative and comparative analyses of pro-aggressive actions of benzodiazepines in maternal aggression of rats

Olivier

1989

Psychopharmacology

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“…Benzodiazepines have been shown to enhance predation in several species of mammalian carnivore (Apfelbach, 1978;Leaf, Wnek, Gay, Corcia, & Lamon, 1975;Leaf, Wnek, & Lamon, 1984;Wolgin & Servidio, 1979). Enhancement of predatory behavior by benzodiazepines might be due to facilitation of attack (directly or indirectly'by increasing hunger; e.g., Della-Fera, Baile, & McLaughlin, 1979;Mereu, Fratta, Chessa, & Gessa, 1976) or to the reduction of defense (by decreasing fear of the prey; e.g., Sepinwall & Cook, 1978).…”

Section: Part 1 Escalation Of Predatory Behavior By the Administratio...mentioning

confidence: 99%

“…Sepinwall & Cook, 1978). Because cats given oxazepam and diazepam showed less defensive behavior toward prey, the escalation of attack induced by these drugs may be due, at least in part, to their anxiolytic properties (see also Apfelbach, 1978;Leaf et al 1975). However, diazepam also facilitated the attack of cats with lateral hypothalamic lesions, which show little, if any, defensive behavior.…”

Section: Killmentioning

confidence: 99%

Escalation of feline predation along a gradient from avoidance through "play" to killing.

O’Brien¹,

Pellis²,

Teitelbaùm³

et al. 1988

Behavioral Neuroscience

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In this article, we show that feline predation involves a continuous gradient of activation between defense and attack and that predatory "play" results from an interaction of the two. Benzodiazepines (oxazepam, diazepam) escalated attack toward killing, so that cats that had avoided mice prior to the drug now played with them, cats that had originally played now killed, and cats that killed mice now did so with less preliminary contact. In such shifts, no sharp demarcation between play and predation was evident. Lateral hypothalamic lesions disrupted the escalation of attack. During recovery, attack was escalated once again along the gradient toward killing, but in the absence of both defense and play. A similar result was obtained in intact killers and nonkillers by the application of mild tail pinch. These results suggest that play with prey is a misnomer for predatory behavior that fails to escalate along the gradient between defense and attack. Movement notation analysis revealed that playful movements are adaptive in that they protect the cat from injury.

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Effects of some physiological and pharmacological manipulations on shock- facilitated mouse killing by onychomys leucogaster (Northern grasshopper mouse)

Clark

1976

Aggr. Behav.

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Onychomys leucogaster (northern grasshopper mice) were induced to kill mice with response‐contingent shock, and the effects of several physiological, pharmacological, and endocrinological variables were assessed. Lesions of the septum facilitated mouse killing, while lesions of the amygdala abolished spontaneous mouse killing and delayed shock‐facilitated killing. Chlorpromazine (2.5–5 mg/kg) and chlordiazepoxide (5–10 mg/kg) facilitated mouse killing on postdrug trials but did not affect killing when the animals were drugged. Adrenalectomy, castration, and castration adrenalectomy did not alter the frequency of kill nor were sex‐related differences in killing noted. These results were compared to those found by others studying the effects of lesions and drugs on mouse killing by rats.

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Chlordiazepoxide and diazepam induced mouse killing by rats

Cited by 43 publications

References 13 publications

Quantitative and comparative analyses of pro-aggressive actions of benzodiazepines in maternal aggression of rats

Quantitative and comparative analyses of pro-aggressive actions of benzodiazepines in maternal aggression of rats

Escalation of feline predation along a gradient from avoidance through "play" to killing.

Effects of some physiological and pharmacological manipulations on shock- facilitated mouse killing by onychomys leucogaster (Northern grasshopper mouse)

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