Chloramphenicol-borate/boronate complex for controlling infections by chloramphenicol-resistant bacteria

Bhattacharya, Prabuddha; Singha, Monisha; Senapati, Kalyan; Saha, Suman; Mandal, Sudipa; Mandal, Santi M.; Ghosh, Ananta K.; Basak, Amit

doi:10.1039/c8ra02227e

Cited by 5 publications

(4 citation statements)

References 34 publications

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“… Chloramphenicol acetyltransferase acetylates the hydroxyl group in chloramphenicol, making it unable to bind correctly to the target site. Haemophilus influenza , Gram-negative Bacilli , Enterobacteriaceae , Acinetobacter , and P. aeruginosa, resist chloramphenicol by using this mechanism [ 53 ]. Aminoglycoside-modifying enzyme, S. aureus , S. pneumoniae , and E. faecalis fight antibiotics by producing enzymes that modify drug molecule and decrease its affinity for binding to 30S subunits [ 54 ].…”

Section: Mechanism Of Bacterial Resistancementioning

confidence: 99%

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Review on the Antibacterial Mechanism of Plant-Derived Compounds against Multidrug-Resistant Bacteria (MDR)

Jubair

Rajagopal

Chinnappan

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Microbial resistance has progressed rapidly and is becoming the leading cause of death globally. The spread of antibiotic-resistant microorganisms has been a significant threat to the successful therapy against microbial infections. Scientists have become more concerned about the possibility of a return to the pre-antibiotic era. Thus, searching for alternatives to fight microorganisms has become a necessity. Some bacteria are naturally resistant to antibiotics, while others acquire resistance mainly by the misuse of antibiotics and the emergence of new resistant variants through mutation. Since ancient times, plants represent the leading source of drugs and alternative medicine for fighting against diseases. Plants are rich sources of valuable secondary metabolites, such as alkaloids, quinones, tannins, terpenoids, flavonoids, and polyphenols. Many studies focus on plant secondary metabolites as a potential source for antibiotic discovery. They have the required structural properties and can act by different mechanisms. This review analyses the antibiotic resistance strategies produced by multidrug-resistant bacteria and explores the phytochemicals from different classes with documented antimicrobial action against resistant bacteria, either alone or in combination with traditional antibiotics.

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Section: Mechanism Of Bacterial Resistancementioning

confidence: 99%

Section: Mechanism Of Bacterial Resistancementioning

confidence: 99%

Review on the Antibacterial Mechanism of Plant-Derived Compounds against Multidrug-Resistant Bacteria (MDR)

Jubair

Rajagopal

Chinnappan

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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show abstract

“…3 Due to its excellent antibacterial properties, stable efficacy, and low price, it has been widely used in animal husbandry and aquaculture. 4 However, CAP has tremendous toxic effects and is readily enriched in animals and humans, which may cause severe and irreversible myelosuppressive reactions resulting in aplastic anemia in humans and animals. 5 For this reason, CAP is explicitly prohibited for animal feeding and treatment in many countries, including Japan, America, and China.…”

Section: Introductionmentioning

confidence: 99%

“…Chloramphenicol antibiotics (including chloramphenicol, florfenicol, and methylsulfonamycin) are widely used in the control of animal bacterial diseases with the advantages of a wide antibacterial spectrum, easy absorption by the body, and low cost of medication. , Among them, chloramphenicol (CAP) is a highly effective broad-spectrum antibiotic with a strong inhibitory effect on Gram-positive and negative bacteria . Due to its excellent antibacterial properties, stable efficacy, and low price, it has been widely used in animal husbandry and aquaculture . However, CAP has tremendous toxic effects and is readily enriched in animals and humans, which may cause severe and irreversible myelosuppressive reactions resulting in aplastic anemia in humans and animals .…”

Section: Introductionmentioning

confidence: 99%

Potential-Resolved Electrochemiluminescence Multiplex Immunoassay for Florfenicol and Chloramphenicol in a Single Sample

Kong,

Fan,

Yao

et al. 2023

Anal. Chem.

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The simultaneous detection of multiple antibiotic residues in food is of great significance for food safety. In this work, a novel dual-potential electrochemiluminescence (ECL) immunoassay was designed for the simultaneous detection of chloramphenicol and fluorfenicol residues in food. Ru@MOF was used as an anodic probe, and SnS2 QDs-PEI-Au-MoS2 was used as a cathodic probe. Notably, the coreactant for both luminophores was K2S2O8, avoiding interactions caused by different kinds of coreactants. Au nanoparticles functionalized with a nitrogen- and sulfur-doped graphene oxide-modified glassy carbon electrode to improve the electron transfer efficiency and provide a larger surface area for immobilization of antigen. The linear range for the detection of florfenicol was determined to be 0.1–1000 ng mL–1 with a detection limit of 0.03 ng mL–1, and the linear range for the detection of chloramphenicol was 0.01–1000 ng mL–1 with a detection limit of 3.2 pg mL–1 by recording the ECL responses at two different excitation potentials. The proposed immunoassay achieved a more stable recovery in the detection of actual samples and provided a new analytical method for the simultaneous detection of florfenicol and chloramphenicol residues with high sensitivity and specificity.

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Synthesis of a tetralone derivative of ampicillin to control ampicillin-resistant Staphylococcus aureus

Chakraborty,

Baindara,

Mondal

et al. 2024

Biochemical and Biophysical Research Communications

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Chloramphenicol-borate/boronate complex for controlling infections by chloramphenicol-resistant bacteria

Abstract: We report the design, synthesis, and bio-studies of novel chloramphenicol-borate/boronate derivatives which could control the infections caused by chloramphenicol-resistant bacteria.

Cited by 5 publications

References 34 publications

Review on the Antibacterial Mechanism of Plant-Derived Compounds against Multidrug-Resistant Bacteria (MDR)

Review on the Antibacterial Mechanism of Plant-Derived Compounds against Multidrug-Resistant Bacteria (MDR)

Potential-Resolved Electrochemiluminescence Multiplex Immunoassay for Florfenicol and Chloramphenicol in a Single Sample

Synthesis of a tetralone derivative of ampicillin to control ampicillin-resistant Staphylococcus aureus

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