Chlamydospore Specific Proteins of Candida albicans

Abstract

Polymorphic yeast, Candida albicans, forms thick-walled structures called chlamydospores in order to survive under adverse conditions. We present proteomic profile changes occurring during chlamydospore formation. Chlamydospores were induced by inoculating C. albicans cells (grown for 48 h) on rice extract and semisolid agar containing tween 80 (1%), and were overlaid by a polyethene sheet to induce microaerophilic conditions at 30 • C. Proteins extracted from chlamydospores and hyphae (producing chlamydospores) were identified by LC-MS/MS analysis. Present datasets include proteomic data (Swath spectral libraries) of chlamydospores and yeast phase cells, as well as methodologies and tools used for the data generation. Further analysis is expected to provide an opportunity to understand modulations in metabolic processes, molecular architecture (i.e., cell wall, membrane, and cytoskeleton) and stress response pathways leading to chlamydospore formation and thus facilitating survival of C. albicans under adverse conditions. Data Set: http://www.peptideatlas.org/PASS/PASS01061 (Username: PASS01061, Password: PF8546i) Data Set License: There is no specific license.

Prevalence and drug susceptibility of clinical Candida species in nasopharyngeal cancer patients in Vietnam

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“…Candida albicans a polymorphic, opportunistic pathogen of humans resides commensally in healthy humans [32,33]. It exists in the form of yeast, hyphal, pseudohyphal or chlymydospores [34,35]. Signi cance of polymorphic nature is associated with its survival strategy gained through evolution that made C. albicans a most versatile organism able to survive under extreme microenvironments [32][33][34][35].…”

“…It exists in the form of yeast, hyphal, pseudohyphal or chlymydospores [34,35]. Signi cance of polymorphic nature is associated with its survival strategy gained through evolution that made C. albicans a most versatile organism able to survive under extreme microenvironments [32][33][34][35]. Therefore it is need of hour to target multifunctional potential molecular candidates to control the treat.…”

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