Chlamydophila abortus infection in the mouse: A useful model of the ovine disease

Caro, M.R.; Buendía, A. J.; Rı́o, Laura Del; Ortega, Nieves; Gallego, María Soledad Carrillo; Cuello, F.; Navarro, J. A.; Sánchez, J.; Salinas, J.

doi:10.1016/j.vetmic.2008.09.029

Cited by 22 publications

(18 citation statements)

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“…abortus and Chlamydophilus abortus (Arce et al, 2009;Caro et al, 2009;Kim et al, 2005;Lin et al, 2003;Stein et al, 2000) is deleterious during pregnancy (Table 1). Below, we describe a few murine models of bacterial infection that have been studied depth to delineate the immune mechanisms involved.…”

Section: Bacterial Infectionsmentioning

confidence: 99%

From mice to women: the conundrum of immunity to infection during pregnancy

Krishnan

Nguyen

McComb

2013

Journal of Reproductive Immunology

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Resistance to infection is the ability of the host to evoke a strong immune response sufficient to eliminate the infectious agent. In contrast, maternal tolerance to the fetus necessitates careful regulation of immune responses. Successful pregnancy requires the maternal host to effectively balance the opposing processes of maternal immune reactivity and tolerance to the fetus. However, this balance can be perturbed by infections which are recognized as the major cause of adverse pregnancy outcome including pre-term labor. Select pathogens also pose a serious threat of severe maternal illness. These include intracellular and chronic pathogens that have evolved immune evasive strategies. Murine models of intracellular bacteria and parasites that mimic pathogenesis of infection in humans have been developed. While human epidemiological studies provide insight into maternal immunity to infection, experimental infection in pregnant mice is a vital tool to unravel the complex molecular mechanisms of placental infection, congenital transmission and maternal illness. We will provide a comprehensive review of the pathogenesis of several infection models in pregnant mice and their clinical relevance. These models have revealed the immunological function of the placenta in responding to, and resisting infection. Murine feto-placental infection provides an effective way to evaluate new intervention strategies for managing infections during pregnancy, adverse fetal outcome and long-term effects on the offspring and mother.

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Section: Bacterial Infectionsmentioning

confidence: 99%

From mice to women: the conundrum of immunity to infection during pregnancy

Krishnan

Nguyen

McComb

2013

Journal of Reproductive Immunology

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“…Chlamydial infection in mice does not induce a chronic infection, instead viable Chlamydia is only detected within 4 weeks post-infection contrasting to the months (may last over a year) before clearance with chlamydial infection in humans (Miyairi et al, 2010). Similarly, C. abortus establishes a persistent infection within the ruminant host but not within mice (Caro et al, 2009). This suggests that there are differences in the way that the host first recognizes the bacteria, which mediates clearance or the induction of persistence.…”

Section: Host Species Diversity In Response To Chlamydia Infectionmentioning

confidence: 99%

Late production of CXCL8 in ruminant oro-nasal turbinate cells in response to Chlamydia abortus infection

Doull

Wattegedera

Longbottom

et al. 2015

Veterinary Immunology and Immunopathology

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Chlamydia abortus is an obligate intracellular bacterium that is an important cause of ovine abortion worldwide. There are reports of abortions in cattle, but these are very rare compared to the reported incidence in sheep. The bacterium is transmitted oro-nasally and can establish a sub-clinical infection until pregnancy, when it can invade the placenta and induce an inflammatory cascade leading to placentitis and abortion. Early host-pathogen interactions could explain differential pathogenesis and subsequent disease outcome in ruminant species. In this study, we assessed the ability of sheep and cattle oro-nasal turbinate cells to sense and respond to C. abortus infection. The cells expressed toll like receptor (TLR) 2, TLR4, nucleotide oligomerization domain (NOD) 1 and NOD-like receptor pyrin domain containing 3 (NLRP3) mRNA. In response to C. abortus infection, both ovine and bovine turbinate cells produce CXCL8 mRNA and protein late in the bacterial developmental cycle, but do not produce IL-1β or TNF-α. The UV-inactivated bacteria did not elicit a CXCL8 response, suggesting that intracellular multiplication of the bacteria is important for activating the signalling pathways. The production of innate immune cytokines from cattle and sheep turbinate cells in response to C. abortus infection was found to be largely similar.

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“…Although mice are not a natural host for C. abortus, this model has been widely used to shed light on immune pathological events of the disease and to test vaccine candidates because of the similarities between the experimental infection in mice and the natural disease in small ruminants (Caro et al, 2009). Moreover, the mouse model provides economical, handling and research advantages (e.g.…”

Section: Introductionmentioning

confidence: 99%