Chlamydomonas reinhardtii chloroplasts as protein factories

A molecular method for the delivery of small molecules and proteins across the cell wall of algae using molecular transporters

“…cell penetrating peptides | imaging | protein delivery A lgae represent a potentially inexpensive, scalable, CO 2 -fixing, solar-powered source of diverse chemical products including biofuels, synthetic building blocks, nanomaterials, recombinant proteins, vaccines, antibodies, medicinal leads, and food additives (1)(2)(3)(4)(5). They are also promising organisms for drug discovery and screening and have recognized value for bioremediation and as biosensors (6)(7)(8).…”

Chimeric spider silk production in microalgae: a modular bionanomaterial

“…They are also able to produce and secrete complex proteins and perform post-transcriptional modifications. They are Generally Regarded As Safe (GRAS), with low risk of virus contamination, prions or bacterial endotoxins, and establish no gene flow with the flora around through pollens as in transgenic plants (Mayfield et al 2007). …”

“…Enzybiotics refers mainly to the antibacterial potential of bacteriophage lytic enzymes endowed with the capacity to degrade bacterial cell wall (Rashel et al 2007 ). This set of enzymes exhibits potential application on burn wounds otherwise susceptible to opportunistic colonization by microorganisms (Merabishvili et al 2009). Thus, an artificial skin graft with antimicrobial properties may present a therapeutic option.…”

A novel expression platform for the production of diabetes-associated autoantigen human glutamic acid decarboxylase (HGAD65)

“…There are several other antigenic proteins that have been produced using this system, including foot-and-mouth disease virus VP1 protein [24], tumor necrosis factorrelated apoptosis-inducing ligand (TRAIL) [25] and the protein E2 of classical swine fever virus [26]. The reader is referred to recent reviews on this area for further information [21,27].…”