Chlamydial infections of poultry and human health

Salisch, H.; Malottki, Kirstin Von; Ryll, M.; Hinz, K.‐H.

doi:10.1079/wps19960021

Cited by 12 publications

(6 citation statements)

References 134 publications

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“…, 2013 , 2014b ). Although poorly documented, reported complications of psittacosis in humans include pericarditis, endocarditis, myocarditis, and myalgia ( Salisch et al. , 1996 ).…”

Section: Discussionmentioning

confidence: 99%

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SINC, a type III secreted protein of Chlamydia psittaci, targets the inner nuclear membrane of infected cells and uninfected neighbors

Mojica

Hovis

Frieman

et al. 2015

MBoC

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“…, 2013 , 2014b ). Although poorly documented, reported complications of psittacosis in humans include pericarditis, endocarditis, myocarditis, and myalgia ( Salisch et al. , 1996 ).…”

Section: Discussionmentioning

confidence: 99%

“…Inhalation via aerosols can cause life-threatening pneumonia ( Smith et al. , 2011 ) and systemic complications, including encephalitis and endocarditis ( Salisch et al. , 1996 ).…”

Section: Introductionmentioning

confidence: 99%

SINC, a type III secreted protein of Chlamydia psittaci, targets the inner nuclear membrane of infected cells and uninfected neighbors

Mojica

Hovis

Frieman

et al. 2015

MBoC

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“…Avian strains are pathogenic to humans, the symptoms being mainly nonspecific and influenza-like, but severe pneumonia, endocarditis, and encephalitis are not uncommon (34). Besides, recent surveys showed that C. psittaci can also be found in nonavian domestic animals and wildlife (17,38,40), although its role in these hosts remains to be clarified.…”

mentioning

confidence: 99%

Transcriptional Response Patterns ofChlamydophila psittaciin Different In Vitro Models of Persistent Infection

Goellner¹,

Schubert²,

Liebler-Tenorio

et al. 2006

Infect Immun

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The obligatory intracellular bacterium Chlamydophila psittaci is the causative agent of psittacosis in birds and humans. The capability of this zoonotic pathogen to develop a persistent phase is likely to play a role in chronicity of infections, as well as in failure of antibiotic therapy and immunoprophylaxis. To elucidate three different in vitro models for transition of C. psittaci to persistence (iron depletion, penicillin G treatment, and gamma interferon [IFN-␥] exposure), a set of 27 genes was examined by mRNA expression analysis using quantitative real-time PCR. While the phenotypical characteristics were the same as in other chlamydiae, i.e., aberrant morphology of reticulate bodies, loss of cultivability, and rescue of infectivity upon removal of inducers, the transcriptional response of C. psittaci to persistence-inducing factors included several new and distinctive features. Consistent downregulation of membrane proteins, chlamydial sigma factors, cell division protein, and reticulate body-elementary body differentiation proteins from 24 h postinfection onward proved to be a general feature of C. psittaci persistence. However, other genes displayed considerable variations in response patterns from one model to another, which suggests that there is no persistence model per se. In contrast to results for Chlamydia trachomatis, late shutdown of essential genes in C. psittaci was more comprehensive with IFN-␥-induced persistence, which is probably due to the absence of a functional tryptophan synthesis operon.

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“…Classical psittacosis represents a systemic disease in psittacine birds of acute, protracted, chronic or subclinical manifestation. Avian strains of the agent are known to be pathogenic to humans, the symptoms being mainly non-specific and influenza-like, but severe pneumonia, endocarditis and encephalitis are not uncommon [24,25]. The possibility of persistent infection in man was first described in the 1950s [26].…”

Section: Discussionmentioning

confidence: 99%

A comparative ultrastructural and molecular biological study on Chlamydia psittaci infection in alpha-1 antitrypsin deficiency and non-alpha-1 antitrypsin deficiency emphysema versus lung tissue of patients with hamartochondroma

et al. 2004

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BackgroundChlamydiales are familiar causes of acute and chronic infections in humans and animals. Human pulmonary emphysema is a component of chronic obstructive pulmonary disease (COPD) and a condition in which chronic inflammation manifested as bronchiolitis and intra-alveolar accumulation of macrophages is common. It is generally presumed to be of infectious origin. Previous investigations based on serology and immunohistochemistry indicated Chlamydophila pneumoniae infection in cases of COPD. Furthermore, immunofluorescence with genus-specific antibodies and electron microscopy suggested involvement of chlamydial infection in most cases of pulmonary emphysema, but these findings could not be verified by PCR. Therefore, we examined the possibility of other chlamydial species being present in these patients.MethodsTissue samples from patients having undergone lung volume reduction surgery for advanced alpha-1 antitrypsin deficiency (AATD, n = 6) or non-alpha-1 antitrypsin deficiency emphysema (n = 34) or wedge resection for hamartochondroma (n = 14) were examined by transmission electron microscopy and PCR.ResultsIn all cases of AATD and 79.4% of non-AATD, persistent chlamydial infection was detected by ultrastructural examination. Intra-alveolar accumulation of macrophages and acute as well as chronic bronchiolitis were seen in all positive cases. The presence of Chlamydia psittaci was demonstrated by PCR in lung tissue of 66.7% AATD vs. 29.0% non-AATD emphysema patients. Partial DNA sequencing of four positive samples confirmed the identity of the agent as Chlamydophila psittaci. In contrast, Chlamydophila pneumoniae was detected only in one AATD patient. Lung tissue of the control group of non-smokers with hamartochondroma was completely negative for chlamydial bodies by TEM or chlamydial DNA by PCR.ConclusionsThese data indicate a role of Chlamydophila psittaci in pulmonary emphysema by linking this chronic inflammatory process to a chronic infectious condition. This raises interesting questions on pathogenesis and source of infection.

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Chlamydial infections of poultry and human health

Cited by 12 publications

References 134 publications

SINC, a type III secreted protein of Chlamydia psittaci, targets the inner nuclear membrane of infected cells and uninfected neighbors

SINC, a type III secreted protein of Chlamydia psittaci, targets the inner nuclear membrane of infected cells and uninfected neighbors

Transcriptional Response Patterns ofChlamydophila psittaciin Different In Vitro Models of Persistent Infection

A comparative ultrastructural and molecular biological study on Chlamydia psittaci infection in alpha-1 antitrypsin deficiency and non-alpha-1 antitrypsin deficiency emphysema versus lung tissue of patients with hamartochondroma

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