Chlamydial and ureaplasmal infections in patients with nonbacterial chronic prostatitis

Abstract

Our study was designed to establish the necessity of routine evaluation of patients with inflammatory (IIIA) and noninflammatory (IIIB) types of nonbacterial prostatitis (NBP) for chlamydial and ureaplasmal infections. From 1999 to 2001, 165 patients with a mean age of 35 years (range 20-54 years) were evaluated for the syndrome of chronic prostatitis. The evaluation included scoring with Prostate Symptom Score Index (PSSI) and NIH Chronic Prostatitis Symptom Index (CPSI), Meares-Stamey test and culturing of post-massage urine portion (fourth glass). In all cases, polymerase chain reaction (PCR)-testing of the semen was performed to establish the persistence of Chlamydia trachomatis (ChT) and Ureaplasma urealyticum (UU). Based on laboratory findings (four glass test and post-massage urine culture), in 69 (42%) of 165 cases, NBP was diagnosed, which includes 30 patients with type IIIA and 39 with type IIIB of NBP. According to semen PCR tests, in 11 (36.6%) of 30 cases with IIIA type of NBP, chlamydial (six cases), ureaplasmal (four cases) and a mixture of both (one case) infections were described. Among 39 patients with IIIB type of NBP test was positive in 14 cases (36%), where UU was presented in eight and ChT in six cases. In patients with previously diagnosed inflammatory as also noninflammatory NBP, according to four glass test, chlamydial and/or ureaplasmal infections can be presented. Although their role in pathogenesis of prostatitis remains speculative, however, testing for infections is highly recommended.

Evaluation of acute and chronic bacterial prostatitis and diagnostic management of chronic prostatitis/chronic pelvic pain syndrome with special reference to infection/inflammation

“…The conclusion is that the major problem, namely that diagnostic material may reflect urethral contamination, is not solved; isolation findings do not correlate with symptoms and prostatitis category of the patient [35].…”

Concentrations of moxifloxacin in plasma and urine, and penetration into prostatic fluid and ejaculate, following single oral administration of 400mg to healthy volunteers

“…are also discussed as aetiological organisms in chronic bacterial prostatitis (CBP). Different studies revealed prevalences of these bacteria between 0.6% to 36.2% in patients with CBP [4][5][6][7]. Krieger and Riley [6] found 16S rDNA sequences of mostly unknown bacteria in 77% of prostatic biopsies of patients with CPPS.…”

La prostatite chronique est-elle une maladie infectieuse ?

“…Ce travail du NIH ne plaide donc pas pour une étiopathogénie infectieuse du SDPC. Des études ont montré des prévalences élevées du C. trachomatis et des mycoplasmes génitaux dans le sperme lors de SDPC [8,15], faisant suspecter leur rôle dans l'étiopa-thogénie du SDPC. Toutefois, l'intérêt de la spermoculture et l'implication de ces micro-organismes dans les symptômes du SDPC restent discutés.…”