Chlamydia trachomatis infection in patients with laparoscopically verified acute salpingitis

Ripa, K T; Svensson, Lovisa; Treharne, J D; Weström, L; Mårdh, Per‐Anders

doi:10.1016/0002-9378(80)91087-x

Cited by 43 publications

(9 citation statements)

References 13 publications

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“…The major studies of reproductive outcomes in women with PID (5-7) have been restricted to the small proportion of PID (8) that is diagnosed in hospital. In the 1980s and 1990s large numbers of serological case-control studies were carried out, comparing serum antibody levels in women with PID, EP or infertility, with controls (9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19). These studies invariably showed strong associations between detection of CT antibodies and reproductive damage, but it was difficult to draw quantitative conclusions from them, partly because of confounding between CT and other pathogens also implicated in reproductive morbidity (20), and partly because of the poor, and imprecisely known, sensitivity and specificity of the assays used (21,22).…”

mentioning

confidence: 99%

Proportion of Tubal Factor Infertility due toChlamydia: Finite Mixture Modeling of Serum Antibody Titers

Ades¹,

Price²,

Kounali³

et al. 2017

Am. J. Epidemiol.

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General rightsThis document is made available in accordance with publisher policies. Please cite only the published version using the reference above. Full terms of use are available: http://www.bristol.ac.uk/pure/about/ebr-terms estimates based on the standard PEF formula from case-control studies were 0% and over 65%.Finite mixture modeling can be applied to serological data to obtain estimates of the proportion of reproductive damage attributable to Chlamydia trachomatis. Further studies should be undertaken using modern assays in contemporary, representative populations. <198 words>

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mentioning

confidence: 99%

Proportion of Tubal Factor Infertility due toChlamydia: Finite Mixture Modeling of Serum Antibody Titers

Ades¹,

Price²,

Kounali³

et al. 2017

Am. J. Epidemiol.

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“…These figures are in good agreement with those reported by other Scandinavian groups from the period. [23][24][25] Dual infection with both M genitalium and C trachomatis as diagnosed by PCR, has been reported in several studies, 10 22 26-29 but in most investigations the two bacteria have more often been found alone than together, indicating that they may act as separate causes of disease. In the present study, some PID and EP patients had antibodies against both M genitalium and C trachomatis simultaneously, which may reflect successive infections in a population with a high burden of STIs.…”

Section: Discussionmentioning

confidence: 99%

A serological study of the role of Mycoplasma genitalium in pelvic inflammatory disease and ectopic pregnancy

Jurstrand

Jensen

Magnuson

et al. 2007

Sexually Transmitted Infections

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Objectives: Establishing a connection between the emerging urogenital tract pathogen Mycoplasma genitalium and upper genital tract infection in women would be of major importance. The aim of this study was to evaluate the association between M genitalium antibodies and pelvic inflammatory disease (PID) and ectopic pregnancy (EP) using a lipid-associated membrane protein-enzyme immunoassay (LAMP-EIA) method. Methods: The LAMP-EIA was used to analyse sera obtained from patients with clinical PID and EP collected in Sweden between February 1984 and April 1986. Sera from healthy pregnant women (Ctrl) collected during approximately the same period were used as controls. Evidence of chlamydial infection was investigated using a commercial anti-Chlamydia trachomatis EIA assay. Results: The LAMP-EIA was specific as determined by a lack of cross-reactivity with other Mycoplasma species. The LAMP-EIA showed that 17% (33/193) of the PID patients were M genitalium positive as compared to 18% (15/82) of the EP patients and 15% (36/246) of the Ctrl women. No significant association could be demonstrated between M genitalium antibodies and PID or EP in crude or adjusted logistic regression. Antibodies against C trachomatis were demonstrated in 54% of the PID and 57% of the EP patients, and also in 37% of the Ctrl women, showing a statistically significant association. Conclusion: No statistically significant association between PID or EP and M genitalium antibodies could be found using the LAMP-EIA, although a slight tendency toward association was found when focusing on younger individuals. P elvic inflammatory disease (PID) almost exclusively affects sexually active fertile women, who then face an increased risk of infertility, ectopic pregnancy (EP) and chronic pelvic pain. The best known causative agents of PID are Neisseria gonorrhoeae and Chlamydia trachomatis. Some studies have indicated that non-gonococcal rather than gonococcal infections of the upper genital tract are more likely to result in infertility and EP.1-3 Although many cases are caused by C trachomatis, some studies have also shown an association between Mycoplasma genitalium infection and PID and infertility. [4][5][6][7] M genitalium was discovered in 1981 when it was isolated from the urethra of two men with non-gonococcal urethritis. 8The infection is sexually transmitted, but the complete pattern of diseases caused by M genitalium has not yet been completely elucidated. The infections tend to run a chronic course and are often asymptomatic.9 10 Experiments with female monkeys where M genitalium was inoculated into the oviducts, resulted in salpingitis followed by a specific antibody response.11 The cross-reactions between M pneumoniae and M genitalium 12 13 have made it difficult to use serology for diagnosis and epidemiological studies, but Wang et al developed and evaluated a Triton X-114 extracted lipid-associated membrane protein (LAMP) assay and found no cross-reactions. 9 14 In the present study we have used sera obtained in the 1980s from women ...

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“…Prinzipiell kann C. trachomatis in der Praxis von der Urethra, der Cervix uteri, aus dem Endometrium, von den Tuben und vom Peritoneum sowie der Leberoberfläche isoliert werden [25]. Die Prävalenz bei asymptomatischen Frauen liegt im Bereich von 2-17 % in Abhängig-keit von den Bedingungen eines Screening, der untersuchten Population, der Zielgruppe, der Lokalisation der Untersuchungseinrichtung und hypothetisch auch der eingesetzten Testmetode.…”

Section: Theorie Und Praxis Der Laparoskopischen Diagnostik Der Pidunclassified

Salpingitis

Hoyme

2015

Gynäkologe

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Chlamydia trachomatis infection in patients with laparoscopically verified acute salpingitis

Cited by 43 publications

References 13 publications

Proportion of Tubal Factor Infertility due toChlamydia: Finite Mixture Modeling of Serum Antibody Titers

Proportion of Tubal Factor Infertility due toChlamydia: Finite Mixture Modeling of Serum Antibody Titers

A serological study of the role of Mycoplasma genitalium in pelvic inflammatory disease and ectopic pregnancy

Salpingitis

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