Chlamydia trachomatis infection co-operatively enhances HPV E6-E7 oncogenes mediated tumorigenesis and immunosuppression

Challagundla, Naveen; Chrisophe-Bourdon, Jean; Agrawal-Rajput, Reena

doi:10.1016/j.micpath.2022.105929

Cited by 8 publications

(12 citation statements)

References 40 publications

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“…233 Thus, HPV/CT co-infection leads to tissue damage, and reduces local regenerative capacity. 234 Various proteins expressed by CT can target different subcellular compartments such as nucleus, endoplasmic reticulum, and mitochondria. These proteins may have detrimental effects on essential biological functions leading to cancer development.…”

Section: Hpv/ct Co-infection and Genome Instabilitymentioning

confidence: 99%

“…CT was also reported to activate PI3K/AKT that enhances cellular proliferation, and blocks cell apoptosis 238 . Additionally, CT manipulates intrinsic apoptotic pathways by degrading the MDM2 protein and inducing expression of antiapoptotic proteins like Mcl‐1 234 . It also creates mitotic spindle defects causing the premature host cells to exit from mitosis without the right corrections 226 .…”

Section: Microbiome and Hpvmentioning

confidence: 99%

“…226 Thus, manipulation of cell survival and death pathways by CT can cause further cellular transformation in HPV-infected individuals. 234 CT creates a vacuole surrounded by a membrane named as "inclusion" in which it can replicate and be ready to infect other cells. [239][240][241] Both CT infection and HPV/CT coinfection trigger the oncogenic MAPK pathway (Ras-Raf-MEK-ERK) that regulates diverse cellular functions including cell proliferation, survival, differentiation, and migration, thus promoting cancer cell growth.…”

Section: Hpv/ct Co-infection and Cell Proliferationmentioning

confidence: 99%

“…238 Additionally, CT manipulates intrinsic apoptotic pathways by degrading the MDM2 protein and inducing expression of antiapoptotic proteins like Mcl-1. 234 It also creates mitotic spindle defects causing the premature host cells to exit from mitosis without the right corrections. 226 Furthermore, cytokine-mediated inflammatory responses caused by chlamydial infection lead to fibrosis, tissue dysfunction, and EMT by deposition of extracellular matrix proteins.…”

Section: Hpv/ct Co-infection and Cell Proliferationmentioning

confidence: 99%

“…The correlation between HPV and CT infections with cervical tissue transformation is based on the steady presence of both pathogens that interfere with the host cells detection and repairing mechanisms 233 . Thus, HPV/CT co‐infection leads to tissue damage, and reduces local regenerative capacity 234 . Various proteins expressed by CT can target different subcellular compartments such as nucleus, endoplasmic reticulum, and mitochondria.…”

Section: Microbiome and Hpvmentioning

confidence: 99%

See 4 more Smart Citations

HPV co‐infections with other pathogens in cancer development: A comprehensive review

Akbari,

Milani,

Seyedinkhorasani

et al. 2023

Journal of Medical Virology

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High‐risk human papillomaviruses (HR‐HPVs) cause various malignancies in the anogenital and oropharyngeal regions. About 70% of cervical and oropharyngeal cancers are caused by HPV types 16 and 18. Notably, some viruses including herpes simplex virus, Epstein–Barr virus, and human immunodeficiency virus along with various bacteria often interact with HPV, potentially impacting its replication, persistence, and cancer progression. Thus, HPV infection can be significantly influenced by co‐infecting agents that influence infection dynamics and disease progression. Bacterial co‐infections (e.g., Chlamydia trachomatis) along with bacterial vaginosis‐related species also interact with HPV in genital tract leading to viral persistence and disease outcomes. Co‐infections involving HPV and diverse infectious agents have significant implications for disease transmission and clinical progression. This review explores multiple facets of HPV infection encompassing the co‐infection dynamics with other pathogens, interaction with the human microbiome, and its role in disease development.

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Section: Hpv/ct Co-infection and Genome Instabilitymentioning

confidence: 99%

Section: Microbiome and Hpvmentioning

confidence: 99%

Section: Hpv/ct Co-infection and Cell Proliferationmentioning

confidence: 99%

Section: Hpv/ct Co-infection and Cell Proliferationmentioning

confidence: 99%

Section: Microbiome and Hpvmentioning

confidence: 99%

See 3 more Smart Citations

HPV co‐infections with other pathogens in cancer development: A comprehensive review

Akbari,

Milani,

Seyedinkhorasani

et al. 2023

Journal of Medical Virology

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show abstract

Human papillomavirus associated cervical lesion: pathogenesis and therapeutic interventions

Ye,

Zheng,

et al. 2023

MedComm

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Human papillomavirus (HPV) is the most prevalent sexually transmitted virus globally. Persistent high‐risk HPV infection can result in cervical precancerous lesions and cervical cancer, with 70% of cervical cancer cases associated with high‐risk types HPV16 and 18. HPV infection imposes a significant financial and psychological burden. Therefore, studying methods to eradicate HPV infection and halt the progression of precancerous lesions remains crucial. This review comprehensively explores the mechanisms underlying HPV‐related cervical lesions, including the viral life cycle, immune factors, epithelial cell malignant transformation, and host and environmental contributing factors. Additionally, we provide a comprehensive overview of treatment methods for HPV‐related cervical precancerous lesions and cervical cancer. Our focus is on immunotherapy, encompassing HPV therapeutic vaccines, immune checkpoint inhibitors, and advanced adoptive T cell therapy. Furthermore, we summarize the commonly employed drugs and other nonsurgical treatments currently utilized in clinical practice for managing HPV infection and associated cervical lesions. Gene editing technology is currently undergoing clinical research and, although not yet employed officially in clinical treatment of cervical lesions, numerous preclinical studies have substantiated its efficacy. Therefore, it holds promise as a precise treatment strategy for HPV‐related cervical lesions.

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High burden of human papillomavirus infection among men in Guangzhou, South China: Implications for HPV vaccination strategies

Liu,

Yang,

Zhao

et al. 2024

Human Vaccines & Immunotherapeutics

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The epidemiological and clinical aspects of Human Papillomavirus (HPV) infection in women have been extensively studied. However, there is a lack of information regarding HPV characteristics in males. In this study, we conducted a retrospective and observational study of 3737 consecutive male individuals attending outpatient clinics of Guangdong Women and Children Hospital from 2012 to 2023 in Guangzhou, South China, to determine the age- and genotype-specific prevalence of HPV in men. The results showed the overall prevalence of HPV among men was 42.15% (1575/3737), with variations ranging from 29.55% to 81.31% across distinct diagnostic populations. Low-risk HPV6 (15.47%), HPV11 (8.94%), and high-risk HPV52 (5.51%) were the most common types. The annual HPV prevalence decreased significantly (Z = −3.882, p < .001), ranging from 31.44% to 52.90%. 28.77% (1075/3737) of men manifested infection with a singular HPV type, predominantly identified as a low-risk type. The age-specific distribution of HPV infections revealed distinctive peaks in the < 25 y age group (47.60%, 208/437) and the 40–44 y age group (44.51%, 154/346). Notably, the positive rate of Chlamydia trachomatis was significantly higher among HPV-positive individuals in comparison to HPV-negatives (16.14% vs. 11.25%, p < .05). Our findings reveal a substantial prevalence of HPV infection among outpatient men in Guangzhou, South China. It is recommended to consider the inclusion of HPV vaccination for adolescent males in national immunization schedules, once an adequate supply of vaccines is accessible.

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Chlamydia trachomatis infection co-operatively enhances HPV E6-E7 oncogenes mediated tumorigenesis and immunosuppression

Cited by 8 publications

References 40 publications

HPV co‐infections with other pathogens in cancer development: A comprehensive review

HPV co‐infections with other pathogens in cancer development: A comprehensive review

Human papillomavirus associated cervical lesion: pathogenesis and therapeutic interventions

High burden of human papillomavirus infection among men in Guangzhou, South China: Implications for HPV vaccination strategies

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