CHLAMYDIA TRACHOMATIS AND HERPES SIMPLEX VIRUS IgA ANTIBODIES IN CERVICAL SECRETIONS OF PATIENTS WITH CERVICAL ATYPIA

Kalimo, Kirsti; Terho, P; Honkonen, Erkki; Grönroos, M.; Halonen, Pekka

doi:10.1111/j.1471-0528.1981.tb01767.x

Cited by 18 publications

(4 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…IgA antibodies for Chlamydia trachomatis were found in the cervical secretions in 13%, 5% and 6% of the women in groups I, I1 and 111, respectively. These numbers are similar to that (1 2%) reported for healthy Finnish women (Kalimo et al 1981).…”

Section: Gardnerella Vaginalis Streptococcus Agalactiaesupporting

confidence: 90%

Microbiology of vaginitis associated with the intrauterine contraceptive device

Kivijärvi

Järvinen

Grönroos

1984

BJOG

View full text Add to dashboard Cite

A malodorous, homogeneous, grey, thin and non-purulent discharge, which resembles non-specific vaginitis occurs in 20% of women with an intrauterine contraceptive device (IUCD); four times more common than in non-users. The aim of this investigation was to study the bacteriological aetiology of this IUCD-associated vaginal discharge, and to assess whether the infection was ascendent. No specific microbiological aetiology was found, but the normal, Lactobacillus-dominated microbial vaginal flora was replaced by Gardnerella vaginalis and certain anaerobic species in TUCD-users with the discharge. Clue cells, pepper-salt phenomenon and curved rods andlor fusiform-shaped rods demonstrated by microscopy, were typical of symptomatic patients. The endometrium and the IUCD were infected with these species in the symptomatic group more often than in IUCD-users who had no symptoms or in the control women who did not use the IUCD.

show abstract

Section: Gardnerella Vaginalis Streptococcus Agalactiaesupporting

confidence: 90%

Microbiology of vaginitis associated with the intrauterine contraceptive device

Kivijärvi

Järvinen

Grönroos

1984

BJOG

View full text Add to dashboard Cite

show abstract

“…Most of the epidemiological studies on CT/HSV co-infection rely on serological data [ 171 ], making it difficult to determine whether or not both pathogens were present simultaneously in the genital tract at any given time. Several studies described a high prevalence of CT and HSV seropositivity among men and women [ 172 , 173 , 174 , 175 ]. In a group of 35 patients with cervical dysplasia or cervical carcinoma, IgA antibodies to HSV were detected in the cervical secretions of 10 (28%), from which nine had IgA antibodies to CT [ 172 ].…”

Section: Co-infections Of Chlamydia Trachomatis An...mentioning

confidence: 99%

“…Several studies described a high prevalence of CT and HSV seropositivity among men and women [ 172 , 173 , 174 , 175 ]. In a group of 35 patients with cervical dysplasia or cervical carcinoma, IgA antibodies to HSV were detected in the cervical secretions of 10 (28%), from which nine had IgA antibodies to CT [ 172 ]. An examination of 88 students from tertiary institutions revealed that 9.1% of the participants had IgG antibodies present for both CT and HSV [ 175 ].…”

Section: Co-infections Of Chlamydia Trachomatis An...mentioning

confidence: 99%

When Bacteria and Viruses Collide: A Tale of Chlamydia trachomatis and Sexually Transmitted Viruses

Ghasemian,

Harding-Esch,

Mabey

et al. 2023

Viruses

View full text Add to dashboard Cite

The global incidence of sexually transmitted infections (STIs) remains high, with the World Health Organization (WHO) estimating that over 1 million people acquire STIs daily. STIs can lead to infertility, pregnancy complications, and cancers. Co-infections with multiple pathogens are prevalent among individuals with an STI and can lead to heightened infectivity and more severe clinical manifestations. Chlamydia trachomatis (CT) is the most reported bacterial STI worldwide in both men and women, and several studies have demonstrated co-infection of CT with viral and other bacterial STIs. CT is a gram-negative bacterium with a unique biphasic developmental cycle including infectious extracellular elementary bodies (EBs) and metabolically active intracellular reticulate bodies (RBs). The intracellular form of this organism, RBs, has evolved mechanisms to persist for long periods within host epithelial cells in a viable but non-cultivable state. The co-infections of CT with the most frequently reported sexually transmitted viruses: human immunodeficiency virus (HIV), human papillomavirus (HPV), and herpes simplex virus (HSV) have been investigated through in vitro and in vivo studies. These research studies have made significant strides in unraveling the intricate interactions between CT, these viral STIs, and their eukaryotic host. In this review, we present an overview of the epidemiology of these co-infections, while specifically delineating the underlying mechanisms by which CT influences the transmission and infection dynamics of HIV and HSV. Furthermore, we explore the intricate relationship between CT and HPV infection, with a particular emphasis on the heightened risk of cervical cancer. By consolidating the current body of knowledge, we provide valuable insights into the complex dynamics and implications of co-infection involving CT and sexually transmitted viruses.

show abstract

“…Dent & Bienenstock (1974), using indirect immunofluorescence, were unable to detect HSV-specific IgA or IgM in the cervicovaginal washings of patients with cervical SCC, although IgG-HSV was detectable in the washings from 37% of patients and 32% of controls. More recently, IgA antibodies to HSV2 were detected by radioimmunoassay in cervical secretions from 21 % of patients with cervical dysplasia and 57 % of patients with cervical cancer, but not in normal controls (Kalimo et al 1981).…”

Section: Introductionmentioning

confidence: 99%

Class-specific herpes simplex virus antibodies in sera and cervical secretions from patients with cervical neoplasia: a multi-group comparison

Dale¹,

Coleman

Best³

et al. 1988

Epidemiol. Infect.

View full text Add to dashboard Cite

SUMMARYSerum and cervical secretions were collected from patients with cervical dysplasia, carcinoma-in-situ (CIS), squamous cell carcinoma (cervical SCC), and controls with normal cervices, attending clinics within the West Lambeth Health District, London. Enzyme-linked immunosorbent assays were used to examine cervical secretory IgA (sIgA) and serum IgG and IgA antibodies to herpes simplex virus (HSV). Sexual and demographic factors were considered during data analysis, which involved fitting multiple linear or multiple logistic regressions to HSV antibody levels. Prevalence of sIgA-HSV and levels of serum antibodies to HSV in all groups were compared with those of gynaecology controls. Caucasian women with mild dysplasia had a significantly higher prevalence of sIgA-HSV. Serum IgG levels to HSV (IgG-HSV) were significantly elevated in women with mild dysplasia and severe dysplasia/CIS. Serum IgA levels to HSV1 (IgG-HSV1) were significantly higher in women with cervical SCC (after adjusting for smoking habits) and other genital tumours. Significantly higher levels of serum IgA to HSV2 (IgA-HSV2) were also found among Caucasian women with cervical SCC. The possible role of HSV as a co-factor in cervical carcinogenesis is discussed.

show abstract

CHLAMYDIA TRACHOMATIS AND HERPES SIMPLEX VIRUS IgA ANTIBODIES IN CERVICAL SECRETIONS OF PATIENTS WITH CERVICAL ATYPIA

Cited by 18 publications

References 8 publications

Microbiology of vaginitis associated with the intrauterine contraceptive device

Microbiology of vaginitis associated with the intrauterine contraceptive device

When Bacteria and Viruses Collide: A Tale of Chlamydia trachomatis and Sexually Transmitted Viruses

Class-specific herpes simplex virus antibodies in sera and cervical secretions from patients with cervical neoplasia: a multi-group comparison

Contact Info

Product

Resources

About