Chlamydia trachomatis and chronic respiratory disease in childhood

Hr, Harrison; Lm, Taussig; Va, Fulginiti

doi:10.1097/00006454-198201000-00008

Cited by 63 publications

(18 citation statements)

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“…A decision maker who considers pyloric stenosis to be more serious than its relative weight in our model, in general or in specific circumstances (for instance, a clinician or parent deciding about prophylaxis for an infant with higher-than-average anesthetic risk), would be less inclined to give erythromycin prophylaxis than the model suggests. On the other hand, if future studies confirm long-term consequences of neonatal chlamydia exposure, as have been suggested by studies [36][37][38] showing that infants with C trachomatis pneumonia may have long-term chronic pulmonary effects and by reports [39][40][41] of infants with neonatal chlamydia infection and myocarditis or sudden infant death syndrome, then the relative value of preventing C trachomatis infection would increase in comparison with avoiding pyloric stenosis.…”

Section: Commentmentioning

confidence: 78%

Oral Erythromycin Prophylaxis vs Watchful Waiting in Caring for Newborns Exposed to Chlamydia trachomatis

Rosenman

Mahon

Downs

et al. 2003

Arch Pediatr Adolesc Med

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Section: Commentmentioning

confidence: 78%

Oral Erythromycin Prophylaxis vs Watchful Waiting in Caring for Newborns Exposed to Chlamydia trachomatis

Rosenman

Mahon

Downs

et al. 2003

Arch Pediatr Adolesc Med

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“…Nevertheless, untreated LRTI may produce signi® cant morbidity and occasionally may result in respiratory failure. 4,9 Long-term pulmonary sequelae with chronic cough, increased rates of asthma and abnormal lung function persisting into childhood have been reported. 9,10 Diagnosis of infected infants also enables identi® cation of infected mothers in whom, complications such as pelvic in¯ammatory disease and infertility may occur unless treated.…”

Section: Discussionmentioning

confidence: 99%

Chlamydia trachomatislower respiratory tract infection in infants

Zar

Dyk

Yeats

et al. 1999

Annals of Tropical Paediatrics

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Chlamydia trachomatis may be an important cause of lower respiratory tract infection (LRTI) in infants born to mothers amongst whom there is a high prevalence of sexually transmitted disease. A study of 100 ambulatory infants with signs of LRTI in South Africa showed that 6% had C. trachomatis infection. The majority of the infected infants had received chloramphenicol eye ointment as prophylaxis. Half had previously visited a health facility for the same illness but the infection has been misdiagnosed. Infants with C. trachomatis infection were According to the Centers for Disease Control (CDC) guidelines, 85% were younger than uninfected infants (mean (SD) age of 3.8 weeks (3.2) vs 8.7 weeks (5.4); p=0.03). Clinical signs significantly associated with chlamydial infection were the presence of eye discharge (p = 0.02) or conjunctivitis (p = 0.01). There was a greater rate of rhinorrhoea (p = 0.06) and wheeze (p = 0.03) amongst patients without chlamydial infection. H. influenzae, M. catarrhalis, S. pneumoniae, S. aureus and N. gonorrhoeae were cultured from five different patients infected with chlamydia. The majority of infants with chlamydial infection had mild disease requiring only outpatient anti- biotic therapy.

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“…The disease is usually mild and does not require hospitalization, but it reportedly accounts for approximately one third of the cases of pneumonia in hospitalized infants from 1-6 months of age and may occasionally be life-threatening [15]. Impairment of lung function may persist for a longer period than after a viral pneumonia [16]. The chlamydia positive SIDS cases in our study were aged between 1-7 months, 86% between 1-4 months in which C. trachomatis pneumonia usually occurs.…”

Section: Discussionmentioning

confidence: 99%

Chlamydia and sudden infant death syndrome. A study of 166 SIDS and 30 control cases

et al. 1990

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Chlamydia inclusions could be demonstrated by an immunofluorescence assay in formalin-fixed lung sections in 32 of 166 cases (19.4%) of Sudden Infant Death Syndrome (SIDS) and in the lungs of only 1 of 30 infants with a known cause of death (3.3%). The difference is statistically significant (P = 0.04). Chlamydia trachomatis is an agent of pneumonia in 1-4 month-old infants who have acquired the disease from an infected cervix during birth, but other chlamydia species are also capable of causing pneumonia. The lung sections of the 32 chlamydia positive SIDS cases did not show typical histological signs of pneumonia. Even though chlamydia inclusions were detected in the lungs of 32 SIDS cases a causal relation between chlamydia infection and SIDS could not be demonstrated.

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Chlamydia trachomatis and chronic respiratory disease in childhood

Cited by 63 publications

References 0 publications

Oral Erythromycin Prophylaxis vs Watchful Waiting in Caring for Newborns Exposed to Chlamydia trachomatis

Oral Erythromycin Prophylaxis vs Watchful Waiting in Caring for Newborns Exposed to Chlamydia trachomatis

Chlamydia trachomatislower respiratory tract infection in infants

Chlamydia and sudden infant death syndrome. A study of 166 SIDS and 30 control cases

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