Chlamydia trachomatis among women with normal and abnormal cervical smears in Lagos, Nigeria

Adegbesan-Omilabu, Maymunah A.; Okunade, Kehinde Sharafadeen; Oluwole, Ayotunde Ayodeji; Gbadegesin, Abidoye; Omilabu, Sunday

doi:10.5455/2320-1770.ijrcog20140905

Cited by 2 publications

(2 citation statements)

References 29 publications

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“…Furthermore, our result showed that the level of knowledge of our subjects on hpv vaccination was low (32.8%) as shown in Table 3. The finding (low level of knowledge) in our present study was consistent with previous works in Taiwan where students exhibited moderate knowledge regarding hpv vaccine [32,33,34] and in Columbia were only 7.8% of subjects knew [35]. However, the present finding is different from that of [36] who reported 51% knowledge of hpv vaccination among respondents and [37] who reported 85% in their study.…”

Section: Resultssupporting

confidence: 87%

Molecular Detection and Typing of Cervical Human Papillomavirus in a Selected Population in Bayelsa State: Comparison with the National and International Trend and Clinical Significance

Oboma

Ngokere

Tatfeng

et al. 2021

BJI

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Background: The link between cervical lesions and human Papillomavirus (HPV) 16 and 18 is well established, but the magnitude of the risk of association and the importance of other high-risk hpv types is uncertain in Bayelsa state. Aims: The study was aimed at detecting and typing of cervical hpv among selected subjects, establish the relationship between cervical dysplasia and hpv and also asses the level of knowledge of hpv, perception and attitude of women in Bayelsa State. Materials and Methods: Questionnaires were used to assess the level of knowledge of hpv and cervical cancer. Papanicolaou stain for cervical cytology and Haematoxylin and Eosin stain used to study general tissue structure. Nested PCR was used to detect and multiplex PCR for typing. Results: The prevalence of hpv spectrum among participants was 52% while high risk hpv was 24%. Five (5) subtypes were identified. The subtypes identified were hpv 52(40.4%) most predominant, followed by 51(1.9%), 45(1.9%), 31(1.9%) and hpv 30 (9.6%). The age-specific prevalence showed a peak prevalence of 44.2% in the ages of 25-34 years and lowest in the age group (15-24years). Sequence alignment showed a single point mutation for hpv 45 and several points' mutation for hpv 52 at certain points of the sequenced nucleotides with Sequence no: 53CN12 and SeqH2011055303 and accession no: MG195999 and MG196000. HPV 52 was highest compared to previous studies, national and international. The level of knowledge on hpv infection and cancer of the cervix was low among subjects with a percentage score of 38.9%. Among other variables studied, life time sexual partners showed a statistically significant relationship in the prevalence of hpv (OR=0.02, P˂0.01). Perceived seriousness on hpv infection was high among hpv positive subjects compared with hpv negative participants ( =16.39, p ˂0.01). Conclusion: The emergence of hpv 52 in the study area requires public health attention and thus urgent need for local hpv vaccines production.

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Section: Resultssupporting

confidence: 87%

Molecular Detection and Typing of Cervical Human Papillomavirus in a Selected Population in Bayelsa State: Comparison with the National and International Trend and Clinical Significance

Oboma

Ngokere

Tatfeng

et al. 2021

BJI

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“…We investigated and found high prevalence of C. trachomatis in controls than in cases which were in disagreement with Adegbesan-Omilabu et al (2014) in Nigeria who reported higher prevalence of C. trachomatis infection in cases than in controls [36]. Equally, Kwaśniewska et al (2007) reported a significantly higher frequency of C. trachomatis occurrence in tissue sections from patients with invasive cervical cancer compared to control without neoplastic lesions [37].…”

Section: Trachomatis As An Independent Predictor Of Cervical Cancermentioning

confidence: 87%

Sero-diagnosis of <i>Chlamydia trachomatis</i> and Molecular Detection of Genital Oncogenic <i>Human Papilloma Virus</i> Among Cameroonian Women

Wabo¹,

Nsagha²,

Nana³

et al. 2020

EJCBS

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Cervical cancer is a preventable public health concern ranking second among women's cancer in Cameroon.Human papilloma virus (HPV) is the main causative agent with Chlamydia trachomatis being suggested as the co-factor. Our objective was to characterize high risk (hr) HPV types and to detect Chlamydia trachomatis antibodies among Cameroonian women with and without cervical cancer. Methods: This unmatched case-control study enrolled 100 cases with cervical cancer and 200 controls with normal cytology aged 25-65 years in four reference hospitals in Douala and Yaoundé (Cameroon). Consented participants filled a structured questionnaire and data on socio-demographic characteristics collected. Chlamydia trachomatis antibodies were detected by the Enzyme Linked Immuno-Sorbent Assay technique (ELISA) and hr HPV-DNA by PCR technique. Descriptive statistics was conducted to provide frequencies and percentages and the logistic regression analysis to assess the association between categorical data. p < 0.05 was considered significant. Results: Our data showed 39 (39.0%) cases aged 39-52 years compared to 96 (48.0%) controls aged 25-38 years (p=0.001). We found 82 (82.0%) cases compared to 131 (65.5%) controls with hr HPV infections. HPV 16 was most prevalent being found in 29 (29.0%) cases compared to 69 (34.5%) controls. Chlamydia trachomatis IgG / hr HPV co-infections were detected in 20 (20.0%) cases compared to 33 (16.5%) controls but with no significant association with cervical cancer (aOR=1.87; 95%CI: 0.58-5.97; p=0.293). Chlamydia trachomatis IgM (aOR=3.50; 95%CI: 1.16-10.49; p=0.025) was significantly associated with cervical cancer. Conclusion: Hr HPV-DNA was high in cases than in controls. Chlamydia trachomatis single infection and Chlamydia trachomatis/hr HPV co-infections were not significantly associated to precancerous lesions thus, necessitating further investigations.

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Chlamydia trachomatis among women with normal and abnormal cervical smears in Lagos, Nigeria

Cited by 2 publications

References 29 publications

Molecular Detection and Typing of Cervical Human Papillomavirus in a Selected Population in Bayelsa State: Comparison with the National and International Trend and Clinical Significance

Molecular Detection and Typing of Cervical Human Papillomavirus in a Selected Population in Bayelsa State: Comparison with the National and International Trend and Clinical Significance

Sero-diagnosis of <i>Chlamydia trachomatis</i> and Molecular Detection of Genital Oncogenic <i>Human Papilloma Virus</i> Among Cameroonian Women

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Chlamydia trachomatis among women with normal and abnormal cervical smears in Lagos, Nigeria

Cited by 2 publications

References 29 publications

Molecular Detection and Typing of Cervical Human Papillomavirus in a Selected Population in Bayelsa State: Comparison with the National and International Trend and Clinical Significance

Molecular Detection and Typing of Cervical Human Papillomavirus in a Selected Population in Bayelsa State: Comparison with the National and International Trend and Clinical Significance

Sero-diagnosis of &lt;i&gt;Chlamydia trachomatis&lt;/i&gt; and Molecular Detection of Genital Oncogenic &lt;i&gt;Human Papilloma Virus&lt;/i&gt; Among Cameroonian Women

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Sero-diagnosis of <i>Chlamydia trachomatis</i> and Molecular Detection of Genital Oncogenic <i>Human Papilloma Virus</i> Among Cameroonian Women