Chlamydia pneumoniae-Specific IgE Is Prevalent in Asthma and Is Associated with Disease Severity

Hahn, David L.; Schure, Allison; Patel, Katir; Childs, Tawanna Sabrina; Drizik, Eduard; Webley, Wilmore C.

doi:10.1371/journal.pone.0035945

Cited by 60 publications

(68 citation statements)

References 55 publications

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“…The presence of other specific IgEs which not induced by OVA sensitization in this study also supported by Hahn et al 29 study in 2012 which reported that Chlamydia pneumonia-specific IgE is prevalent in asthma and associated with asthma severity. Therefore, there must be "still undiscovered" specific-IgE which produced after PgLPS injection.…”

Section: Methodssupporting

confidence: 89%

New concept in allergy: Non-allergic rats becomes allergic after induced by Porphyromonas gingivalis lipopolysaccharide

Utomo

2013

Dent. J. (Majalah Kedokteran Gigi)

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Section: Methodssupporting

confidence: 89%

New concept in allergy: Non-allergic rats becomes allergic after induced by Porphyromonas gingivalis lipopolysaccharide

Utomo

2013

Dent. J. (Majalah Kedokteran Gigi)

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“…C. pneumoniae infection is also associated with asthma and, in particular, asthma exacerbation. C. pneumoniae-specific IgE is prevalent in asthma patients, and occurrence of these species-specific antibodies is associated with disease severity [73]. The most widely accepted association of C. pneumoniae respiratory infection with exacerbation of asthma is documented by multiple epidemiologic and clinical studies, some of which investigated whether antibiotic treatment in asthma patients improves outcome.…”

Section: Chlamydia Pneumoniae: Respiratory Infections Coronary Artermentioning

confidence: 99%

Chronic Chlamydial Diseases: From Atherosclerosis to Urogenital Infections

Leonard

Borel

2014

Curr Clin Micro Rpt

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Chlamydiae cause a wide range of diseases in human and animal hosts. Chlamydia pneumoniae and Chlamydia trachomatis are important human pathogens with worldwide distribution that produce significant morbidity. Acute infections with C. pneumoniae cause respiratory tract infections, while chronic infection has been linked to chronic bronchitis, asthma and atherosclerosis. Ocular serovars of C. trachomatis induce trachoma, the leading cause of infectious blindness worldwide. C. trachomatis is the most common bacterial cause of sexually transmitted diseases (STDs) worldwide. Acute infections with genital serovars of C. trachomatis remain clinically silent in most women, but can progress to upper genital tract infection leading to pelvic inflammatory disease (PID), infertility and ectopic pregnancy. Chlamydiainduced, reactive arthritis can develop as a late-term condition after genital C. trachomatis or respiratory C. pneumoniae infection. In this review, we address recent information on pathogenesis, immune response, diagnosis and treatment of chronic diseases induced by C. trachomatis and C. pneumoniae. Abstract:Chlamydiae cause a wide range of diseases in human and animal hosts. Chlamydia pneumoniae and Chlamydia trachomatis are important human pathogens with worldwide distribution that produce significant morbidity. Acute infections with C. pneumoniae cause respiratory tract infections, while chronic infection has been linked to chronic bronchitis, asthma and atherosclerosis. Ocular serovars of C. trachomatis induce trachoma, the leading cause of blindness worldwide. C. trachomatis is the most common bacterial cause of sexually-transmitted diseases (STDs) worldwide. Acute infections with genital serovars of C. trachomatis remain clinically silent in most women but can progress to upper genital tract infection leading to pelvic inflammatory disease (PID), infertility and ectopic pregnancy. Chlamydia-induced, reactive arthritis can develop as a late-term condition after genital C. trachomatis or respiratory C. pneumoniae infection. In this review we address recent information on pathogenesis, immune

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“…A meta-analysis reported an association with lung cancer in patients with previous C pneumoniae infections, 7 while others have posited an association with development of asthma. 8,9 Legionellosis, better known as Legionnaires' disease, is caused by L pneumophila and is most commonly diagnosed as a cause of CAP in patients over 50 years of age, and more often in men than women. The organism is found naturally in the environment, and the infection is associated with inhalation of aerosolized water from sources such as hot tubs and cooling towers.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Atypical Pathogens in Patients With Cough and Community-Acquired Pneumonia: A Meta-Analysis

Marchello

Dale

Thai

et al. 2016

The Annals of Family Medicine

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PURPOSE Community-acquired pneumonia (CAP), acute cough, bronchitis, and lower respiratory tract infections (LRTI) are often caused by infections with viruses or Streptococcus pneumoniae. The prevalence of atypical pathogens Mycoplasma pneumoniae, Chlamydophila pneumoniae, Legionella pneumophila, and Bordetella pertussis among patients with these illnesses in the ambulatory setting has not been previously summarized. We set out to derive prevalence information from the existing literature. METHODSWe performed a systematic review of MEDLINE for prospective, consecutive-series studies reporting the prevalence of M pneumoniae, C pneumoniae, L pneumophila and/or B pertussis in outpatients with cough, acute bronchitis, LRTI, or CAP. Articles were independently reviewed by 2 authors for inclusion and abstraction of data; discrepancies were resolved by consensus discussion. A meta-analysis was performed on each pathogen to calculate the pooled prevalence estimates using a random effects model of raw proportions.RESULTS Fifty studies met our inclusion criteria. While calculated heterogeneity was high, most studies reported prevalence for each pathogen within a fairly narrow range. In patients with CAP, the overall prevalences of M pneumoniae and C pneumoniae were 10.1% (95% CI, 7.1%-13.1%) and 3.5% (95% CI, 2.2%-4.9%), respectively. Consistent with previous reports, M pneumoniae prevalence peaked in roughly 6-year intervals. Overall prevalence of L pneumophila was 2.7% (95% CI, 2.0%-3.4%), but the organism was rare in children, with only 1 case in 1,765. In patients with prolonged cough in primary care, the prevalence of B pertussis was 12.4% (95% CI, 4.9%-19.8%), although it was higher in studies that included only children (17.6%; 95% CI, 3.4%-31.8%).CONCLUSIONS Atypical bacterial pathogens are relatively common causes of lower respiratory diseases, including cough, bronchitis, and CAP. Where surveillance data were available, we found higher prevalences in studies where all patients are tested for these pathogens. It is likely that these conditions are underreported, underdiagnosed, and undertreated in current clinical practice.

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Chlamydia pneumoniae-Specific IgE Is Prevalent in Asthma and Is Associated with Disease Severity

Cited by 60 publications

References 55 publications

New concept in allergy: Non-allergic rats becomes allergic after induced by Porphyromonas gingivalis lipopolysaccharide

New concept in allergy: Non-allergic rats becomes allergic after induced by Porphyromonas gingivalis lipopolysaccharide

Chronic Chlamydial Diseases: From Atherosclerosis to Urogenital Infections

Prevalence of Atypical Pathogens in Patients With Cough and Community-Acquired Pneumonia: A Meta-Analysis

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