Chlamydia pneumoniae e Mycoplasma pneumoniae nos nódulos de calcificação da estenose da valva aórtica

Abstract

ObjectiveWe investigated whether Chlamydia pneumoniae (CP) and Mycoplasma pneumoniae (MP) are present in aortic valve stenosis (AS). Methods Immunohistochemistry was utilized to identify ResultsThe positive area fraction of CP antigen median values were 0. 09, 0.30, 0.18, 1.33, and 3.3

Demonstration of Chlamydophila pneumoniae, Mycoplasma pneumoniae, Cytomegalovirus, and Epstein-Barr virus in atherosclerotic coronary arteries, nonrheumatic calcific aortic and rheumatic stenotic mitral valves by polymerase chain reaction

“…has been considered as typical parasites of respiratory and genitourinary tract epithelium, however Higuchi et al (10) speculated that M. pneumoniae together with C. pneumoniae, were frequently present in atherosclerotic plaques also. Same authors hypothesized also that these agents might play an important role in the development of aortic valve calcification and they found higher concentration of both agents in calcific aortic valves compared to normal aortic valves.…”

“…On the other hand, the association between infectious agents and calcified aortic valve stenosis (CAS) has been investigated in a limited number of studies (2)(3)(4)(5)(6)(7)(8)(9)(10)(11). For many years, degenerative aortic stenosis was thought to be caused by the passive accumulation of calcium on the surface of the aortic valve leaflet.…”

“…Chlamydophila pneumoniae (2-4, 10, 11) and Mycoplasma pneumoniae (10) have been found to be associated with stenotic aortic valves in patients undergoing aortic valve replacement. A high prevalence of cytomegalovirus (CMV) DNA was detected in aortic walls of aortic valve replacement patients (18).…”

Involvement of TLR2 and TLR4, <i>Chlamydophila pneumoniae</i> and <i>Mycoplasma pneumoniae</i> in adventitial inflammation of aortic atherosclerotic aneurysm

“…However, in 148 thoracic and abdominal aortic dissections, real-time PCR (using the Taqman system) was negative for Cp in all cases [28]. Cp and Mp antigens were detected in 100% of calcified aortic valves [29] and in mild atherosclerosis of aorta [30]. Higher amount of Cp and Mp was detected in adventitia of AAA [13].…”

Infectious agents is a risk factor for myxomatous mitral valve degeneration: A case control study

“…In previous studies, the presence of various symbiotic bacteria has been associated with the formation of tissue injury. In the aortic valve, Chlamydophila pneumoniae and Mycoplasma pneumoniae proliferation was associated with tissue calcification and aortic valve stenosis [16, 17]. Roggerio et al studied the relationship between Mycoplasma pneumoniae and Chlamydophila pneumoniae in aortic aneurysms and identified these bacteria in the adventitia of the aorta, concluding that infectious agents, acting symbiotically, can contribute to the development of aortic aneurysms, initiating inflammation and contributing to the disease process [18].…”