CHL1 depletion affects dopamine receptor D2-dependent modulation of mouse behavior
Luciana Fernandes,
Ralf Kleene,
Ludovica Congiu
et al.
Abstract:IntroductionThe dopaminergic system plays a key role in the appropriate functioning of the central nervous system, where it is essential for emotional balance, arousal, reward, and motor control. The cell adhesion molecule close homolog of L1 (CHL1) contributes to dopaminergic system development, and CHL1 and the dopamine receptor D2 (D2R) are associated with mental disorders like schizophrenia, addiction, autism spectrum disorder and depression.MethodsHere, we investigated how the interplay between CHL1 and D… Show more
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