Chitotriosidase, interleukin-1 beta and tumor necrosis factor alpha levels in mild preeclampsia

Alanbay, İbrahim; Çoksüer, Hakan; Ercan, Cihangir Mutlu; Üstün, Yusuf; Pala, Gursoy; Karaşahin, Kazım Emre; Öztürk, Özlem; Kurt, İsmail; Başer, İskender

doi:10.1007/s00404-011-2157-6

Cited by 16 publications

(10 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Interestingly in the present study, levels of both TNF-α and IL-1β were significantly higher in the PE and PE-PTZ groups. Such an increase in inflammatory cytokines not only supports the concept of inflammatory mechanisms contributing to the pathogenesis of preeclampsia [10], [30], but also raises the possibility that such an increase may be contributory to the susceptibility to seizure activity in vivo in the PE-PTZ group. The significantly decreased TNF-α level in the PE-PTZ-Mg group compared to the PE-PTZ group is also consistent with this idea.…”

Section: Discussionsupporting

confidence: 59%

See 1 more Smart Citation

Decreased Seizure Threshold in an Eclampsia-Like Model Induced in Pregnant Rats with Lipopolysaccharide and Pentylenetetrazol Treatments

Huang

Liu

et al. 2014

PLoS ONE

View full text Add to dashboard Cite

ObjectiveEclampsia is a poorly understood but potentially fatal complication of pregnancy. Research to date on this disorder has been hampered by the lack of a suitable animal model. To correct this deficiency, this report describes the generation of a rat eclampsia-like model using pentylenetetrazol (PTZ) in a previously established rat preeclampsia model.MethodRats were administered lipopolysaccharide (1.0 µg/kg) by tail vein injection on gestational day 14 to establish preeclampsia (PE). PE and control rats (non-pregnant, NP; normal-pregnant, P) were injected intraperitoneally (i.p.) with PTZ (40 mg/kg) to induce seizures. In separate experiments, MgSO4 (270 mg/kg IP) was injected in advance of PTZ into PE rats to observe its effect on PTZ-induced seizures.ResultsPE conditions were verified in rats after LPS administration by significantly higher blood pressure (P<0.01) and urinary albumin excretion (P<0.05), elevated sFlt-1 (P<0.05) and decreased PlGF serum levels (P<0.05), and evidence of hepatic dysfunction compared to control groups. PTZ successfully induced seizure activity in all groups studied. Latency to seizure was significantly (P<0.01) less in the PE-PTZ group (73.2±6.6 sec.) than in PTZ-treated controls (107.0±7.4 sec.). Pretreatment with MgSO4 prolonged (P<0.05) latency to seizure, shortened seizure duration and decreased seizure rates. Significant increased (P<0.05) in the serum levels of the inflammatory cytokines TNF-α and IL-1β in PE and PE-PTZ groups, and decreased (P<0.05) in their levels following MgSO4 administration.ConclusionThis PTZ-induced eclampsia-like rat model is comparable to the human condition of eclampsia and may serve as a useful research tool for future studies of this disease. The increased inflammatory cytokines in preeclampsia are coincident with a decreased threshold for PTZ-induced seizures, suggesting that an inflammatory mechanism may contribute to the susceptibility to seizure activity and inflammation might have an important role in eclampsia.

show abstract

Section: Discussionsupporting

confidence: 59%

“…The cytokines TNF-α and IL-1β are primarily produced by macrophages and in preeclampsia participate in abnormal extravillous trophoblast invasion [29], [30]. Tosun et al [31] recently showed that the serum level of TNF-α was significantly increased in preeclamptic patients, especially in severe preeclampsia.…”

Section: Discussionmentioning

confidence: 99%

Decreased Seizure Threshold in an Eclampsia-Like Model Induced in Pregnant Rats with Lipopolysaccharide and Pentylenetetrazol Treatments

Huang

Liu

et al. 2014

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…IL-1β has previously been found to increase the production of TNF-α, IL-6, HCG, endothelia [10], [17], [25], which were proved to be associated with the development of PE. IL-1β may also involve in the oxidative stress linked with PE by stimulating the secretion of other lymphocytotropic cytokines and catabolic enzymes [26].…”

Section: Discussionmentioning

confidence: 93%

Interleukin-1β-31C/T and -511T/C Polymorphisms Were Associated with Preeclampsia in Chinese Han Population

et al. 2014

View full text Add to dashboard Cite

ObjectiveThe purpose of our study is to investigate the relationship between IL-1β -31C/T (rs1143627) and -511T/C (rs16944) polymorphisms and the preeclampsia (PE), and analyze the Linkage disequilibrium (LD) and haplotype frequency of the two polymorphism loci.MethodsPolymorphisms at -31C/T and -511T/C of IL-1β were genotyped with the method of polymerase chain reaction-restriction fragment length polymorphism (PCR- RFLP) in 232 PE and 447 control subjects. Genotype and allele frequencies between case-control groups were compared by chi-square(X2) tests. Two-point LD and haplotype frequency analyses were done with the software Haploview4.2.ResultsSignificant statistical differences were found between PE and control groups regarding genotype and allele frequencies of the two polymorphisms of IL-1β (For IL-1β -31C/T: X2 = 11.478, P = 0.003; For IL-1β-511T/C: X2 = 9.687, P = 0.008). LD analysis revealed that the IL-1β -31C/T SNP was in high LD with the IL-1β-511C/T SNP(D′ = 0.92, r2 = 0.79). Both CT and TC haplotypes showed significant differences between case and control groups. Only the plasma level of Prothrombin Time had a significantly statistical difference among TT, CT and CC groups of the preeclamptic two polymorphisms of IL-1β-31C/T and -511T/C (for IL-1β-31C/T, F = 1.644, P = 0.01; F = 1.587, P = 0.016).ConclusionOur results revealed IL-1β was associated with the PE in Chinese Han population. The CT haplotype may increase the risk of PE, while haplotype TC could be considered as a protective haplotype of PE.

show abstract

“…Detectable IL-6 was also associated with term preeclampsia and had borderline significance with all preeclampsia cases. IL-6 has been associated with preeclampsia in some [11, 12, 15, 17] but not all [8, 18, 19, 22] cross-sectional third trimester studies. In contrast, a nested case-control study of 71 women who developed subsequent preeclampsia and 71 matched (age, parity, and BMI) controls found no significant associations with IL-1β, IL-6, IL-10, TNF-α, or PAI-1 measured by ELISA at 18 weeks gestation [24].…”

Section: Discussionmentioning

confidence: 99%

Mid-pregnancy circulating immune biomarkers in women with preeclampsia and normotensive controls

Taylor

Tang

Ness

et al. 2016

Pregnancy Hypertension: An International Journal of Women's Car

View full text Add to dashboard Cite

Objectives To determine if mid-pregnancy circulating immune biomarkers are associated with preeclampsia. Study Design Nested case-control study of 410 preeclamptic women and 297 normotensive controls with primiparous singleton pregnancies enrolled in the Danish National Birth Cohort. The mean gestational age in our cohort is 16 weeks (range 9–26). Main Outcome Measures Preeclampsia was defined by blood pressure ≥ 140/90mmHg and proteinuria ≥3g/24h. Serum immune biomarkers included interleukin (IL)-6, IL-6 receptor, IL-4, IL-4 receptor, IL-5, IL-12, IL-2, TNF-α, TNF-β, TNF-receptor, IL-1β, IL-1α, IL-8, IL-10, IFN-γ, IL-18, macrophage migration inhibitory factor, macrophage inflammatory protein, transforming growth factor-beta (TGF-β), and RANTES. Associations with preeclampsia, term preeclampsia and preterm preeclampsia were determined using two logistic regression models; 1) biomarkers were dichotomized by the limit of detection (LOD): 2) on the continuous scale, non-detectable values were imputed by LOD/2 and transformed (base 2). All models were adjusted for body mass index and smoking. Results IL1β was significantly associated with a decrease in the log odds of preeclampsia (p=0.0065), term preeclampsia (p=0.0230) and preterm preeclampsia (p=0.0068). Results were similar for IL4r and preeclampsia (p=0.0383). In the dichotomized models, detectable TNF-β was significantly associated with preeclampsia (ORadj 1.6, 95% CI 1.1–2.3) and term preeclampsia (ORadj 1.7, 95% CI 1.1–2.5) but not preterm preeclampsia. Detectable IL6 was significantly associated with term preeclampsia only (ORadj 1.5, 95% CI 1.1–2.2). Conclusion Mid-pregnancy circulating IL1β, IL4r, IL6, and TNFβ were associated with preeclampsia. However, results were not consistent across statistical models. As the relationship is complex, future studies should explore cytokine clusters in preeclampsia risk.

show abstract

Chitotriosidase, interleukin-1 beta and tumor necrosis factor alpha levels in mild preeclampsia

Abstract: Mild preeclampsia is found associated with higher ChT activity. This result suggests that activated macrophages play a role in the pathogenesis of preeclampsia. This suggestion needs to be confirmed in future studies with larger populations.

Cited by 16 publications

References 40 publications

Decreased Seizure Threshold in an Eclampsia-Like Model Induced in Pregnant Rats with Lipopolysaccharide and Pentylenetetrazol Treatments

Decreased Seizure Threshold in an Eclampsia-Like Model Induced in Pregnant Rats with Lipopolysaccharide and Pentylenetetrazol Treatments

Interleukin-1β-31C/T and -511T/C Polymorphisms Were Associated with Preeclampsia in Chinese Han Population

Mid-pregnancy circulating immune biomarkers in women with preeclampsia and normotensive controls

Contact Info

Product

Resources

About