Chitosan/Xanthan membrane containing hydroxyapatite/Graphene oxide nanocomposite for guided bone regeneration

Souza, Alana P.C.; Neves, José Guilherme; Rocha, Daniel Navarro da; Lopes, Camila Cristine; Moraes, Ângela Maria; Correr-Sobrinho, Lourenço; Correr, Américo Bortolazzo

doi:10.1016/j.jmbbm.2022.105464

Cited by 8 publications

(15 citation statements)

References 27 publications

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“…It was possible to identify the presence of GO in the fibers, and this finding is consistent with results observed in recent studies. 18,19 The bands around 1339 cm −1 in the scaffold, which contain GO in their composition, correspond to the D band, while the bands around 1594 cm −1 represent the G band. These bands are slightly shifted compared to the initial study of HAGO by Lopes et al 17 This displacement of the D and G bands found in GO may be attributed to the state of molecular vibrations and the biomaterial synthesis method.…”

Section: Resultsmentioning

confidence: 99%

“…The results of the bands presented are similar to those shown in Figure 5(b) and 5(c), corresponding to the spectra of HA and GO particles, which align with peaks previously presented in earlier studies. 16 –19…”

Section: Resultsmentioning

confidence: 99%

“…32 Our previous studies show that the addition of HA and HAGO in the biomaterial structure improves biological properties, creating a surface that favors the application of these biomaterials in advanced cellular therapies. 11,18,19…”

Section: Resultsmentioning

confidence: 99%

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Cellulose acetate scaffold containing hydroxyapatite/graphene oxide nanocomposite by electrospinning for advanced regenerative therapies

Menezes,

Navarro da Rocha,

Carajelescov Nonato

et al. 2024

Journal of Bioactive and Compatible Polymers

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The aim of this study was to synthesize and characterize Cellulose Acetate (CA) porous scaffolds using the electrospinning technique associated with Hydroxyapatite (HA) and different concentrations of graphene oxide (GO), for advanced regenerative therapies application. The scaffolds were categorized into four distinct groups based on their composition: (1) Pure CA scaffolds; (2) CAHA scaffolds; (3) CAHAGO 1.0% scaffolds; (4) CAHAGO 1.5% scaffolds. Transmission Electron Microscopy (TEM) was used for the characterization of the nanocomposite. The scaffolds were analyzed by X-Ray Diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR), Raman Spectroscopy, Scanning Electron Microscopy with Energy Dispersive Spectroscopy (SEM/EDS), and in vitro cell viability assays (WST). For the biological test analysis of Variance (two-way) was used, followed by Tukey’s post-test (α = 0.05). The TEM analysis allowed for the visualization of the deposition of HA on the graphene sheets, confirming the synthesis of the nanocomposite. XRD revealed the predominant presence of CaP phases in the CAHA, CAHAGO 1.0%, and CAHAGO 1.5% groups, underscoring the inherent mineral composition of the scaffolds. FTIR demonstrated cellulose characteristics and PO4 bands in the groups containing HA, confirming the effective incorporation of this material. Raman spectroscopy revealed distinct peaks in the GO groups, conclusively verifying the successful integration of graphene into the scaffold matrix. The micrographs showcased irregular pores filling the entire surface, arising from the intricate overlapping of fibers during scaffold formation. Importantly, all scaffolds exhibited excellent cell viability in the conducted assays. A proliferation process was observed in CAHA and CAHAGO 1.5% groups after 48 h ( p < 0.05). In conclusion, the scaffolds synthesized hold significant promise in the realm of tissue engineering and provide a fresh perspective on the possibilities for regenerative therapies.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Cellulose acetate scaffold containing hydroxyapatite/graphene oxide nanocomposite by electrospinning for advanced regenerative therapies

Menezes,

Navarro da Rocha,

Carajelescov Nonato

et al. 2024

Journal of Bioactive and Compatible Polymers

Self Cite

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“…Liu et al [ 150 ] demonstrated that GO-based chitosan composites with a lamellar conformation were able to promote the ordered growth of bone cell line MC3T3-E1 along the longitudinal direction. GO-based chitosan composites can simultaneously host toughening agents, such as hydroxyapatite [ 151 ] or another macrobiomolecule [ 152 , 153 ], to enhance its performance as a bone scaffold, without producing collateral reactions. Similar materials have been used for both cartilage [ 154 , 155 ] and dentary pulp [ 156 ] replacements.…”

Section: Carbon-containing Biopolymer Composites For Biomedical Appli...mentioning

confidence: 99%

A Short Review on Nanostructured Carbon Containing Biopolymer Derived Composites for Tissue Engineering Applications

2023

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The development of new scaffolds and materials for tissue engineering is a wide and open realm of material science. Among solutions, the use of biopolymers represents a particularly interesting area of study due to their great chemical complexity that enables creation of specific molecular architectures. However, biopolymers do not exhibit the properties required for direct application in tissue repair—such as mechanical and electrical properties—but they do show very attractive chemical functionalities which are difficult to produce through in vitro synthesis. The combination of biopolymers with nanostructured carbon fillers could represent a robust solution to enhance composite properties, producing composites with new and unique features, particularly relating to electronic conduction. In this paper, we provide a review of the field of carbonaceous nanostructure-containing biopolymer composites, limiting our investigation to tissue-engineering applications, and providing a complete overview of the recent and most outstanding achievements.

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“…However, membranes are often used in other biomedical applications, such as in the developing of artificial organs (artificial liver, oxygenator and pancreas) for increasing the optimal functionalization of physiological functions of the organs [ 25 , 26 , 27 ]. Further, the application of polymeric membranes in tissue engineering has been highly studied due to their biofunctionality, good mechanical properties and the ability of a possible reparation and regeneration of injured tissues/organs [ 28 , 29 , 30 , 31 , 32 , 33 ]. Another application of polymeric membranes in the biomedical field is represented by the developing drug delivery system based on membranes [ 34 ] or different separation interest molecules such as antibiotics [ 35 , 36 , 37 ] or proteins [ 38 ].…”

Section: Introductionmentioning

confidence: 99%

Polymeric Membranes for Biomedical Applications

2023

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Polymeric membranes are selective materials used in a wide range of applications that require separation processes, from water filtration and purification to industrial separations. Because of these materials’ remarkable properties, namely, selectivity, membranes are also used in a wide range of biomedical applications that require separations. Considering the fact that most organs (apart from the heart and brain) have separation processes associated with the physiological function (kidneys, lungs, intestines, stomach, etc.), technological solutions have been developed to replace the function of these organs with the help of polymer membranes. This review presents the main biomedical applications of polymer membranes, such as hemodialysis (for chronic kidney disease), membrane-based artificial oxygenators (for artificial lung), artificial liver, artificial pancreas, and membranes for osseointegration and drug delivery systems based on membranes.

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Chitosan/Xanthan membrane containing hydroxyapatite/Graphene oxide nanocomposite for guided bone regeneration

Cited by 8 publications

References 27 publications

Cellulose acetate scaffold containing hydroxyapatite/graphene oxide nanocomposite by electrospinning for advanced regenerative therapies

Cellulose acetate scaffold containing hydroxyapatite/graphene oxide nanocomposite by electrospinning for advanced regenerative therapies

A Short Review on Nanostructured Carbon Containing Biopolymer Derived Composites for Tissue Engineering Applications

Polymeric Membranes for Biomedical Applications

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