Chitosan/TPP microparticles obtained by microemulsion method applied in controlled release of heparin

Martins, Alessandro F.; Oliveira, Daiane Marques de; Pereira, Antonio G.B.; Rubira, Adley F.; Muniz, Edvani C.

doi:10.1016/j.ijbiomac.2012.08.032

Cited by 149 publications

(83 citation statements)

References 27 publications

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“…CS microparticles were dissolved in different solvents like water, ethanol, phosphate buffer saline (PBS pH 6) and acetic acid at the concentration of 1 mg ml -1 and used to study the drug release kinetics. Absorbanace at 425nm asymmetric stretching vibration of the PO 2 groups), 1090-1115 (symmetric and asymmetric stretching vibration of the PO 3 groups) and 880-895 cm -1 (P-O-P asymmetric stretching) (Mi et al 1999;Martins et al 2012) (Fig. 1a, c, e).…”

Section: Antibacterial Activitymentioning

confidence: 91%

“…TPP concentration might have influenced the shape variations. Martins et al (2012) found that CS/TPP molar ratio at pH 5 favored the formation of more compacted particles, whereas CS/TPP molar ratio at pH 2 did not favor the formation of small particles as well as those formed were irregularly shaped large clusters. Therefore, the CS/TPP ratio and the pH clearly influenced the size and porosity of CS/TPP particles.…”

Section: Antibacterial Activitymentioning

confidence: 92%

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Chelators influenced synthesis of chitosan–carboxymethyl cellulose microparticles for controlled drug delivery

et al. 2016

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In this study, polyphenolic curcumin is entrapped within microcomposites made of biopolymers chitosan (CS) and carboxymethyl cellulose (CMC) formulated by ionic gelation method. Here, different concentrations of two chelating agents, barium chloride and sodium tripolyphosphate, are used to make microcomposites. Thus, the synthesized microparticles were characterized by FTIR, and their surface morphology was studied by SEM. Drug encapsulation efficiency and the drug release kinetics of CS-CMC composites are also studied. The produced microcomposites were used to study antibacterial activity in vitro.

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Section: Antibacterial Activitymentioning

confidence: 91%

Section: Antibacterial Activitymentioning

confidence: 92%

Chelators influenced synthesis of chitosan–carboxymethyl cellulose microparticles for controlled drug delivery

et al. 2016

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“…Interactions between the chitosan and ionic crosslinkers occurred through electrostatic interactions, which involve protonated of the amino group of chitosan and the negatively charged anionic group of TPP and sulfate. 7,20,21 Nanoparticles were then dried and characterized to investigate the physical characteristics and magnetic properties of each material with various composition ratio and crosslinking time. (Fig.…”

Section: Chitosan-coated Fe3o4 Nanoparticles Synthesismentioning

confidence: 99%

"CHARACTERISTICS AND MAGNETIC PROPERTIES OF CHITOSAN-COATED Fe3O4 NANOPARTICLES PREPARED BY EX-SITU CO-PRECIPITATION METHOD"

2017

RJC

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Chitosan-coated iron oxide nanoparticles were synthesized by ex-situ co-precipitation method. Ammonia solution was dropped into the solution containing ferrous and ferric salts through a syringe pump to form Fe3O4 nanoparticles. Nanoparticles produced were then coated and crosslinked with chitosan and tripolyphosphate/sulfate, respectively. The physical and magnetic properties of chitosan-Fe3O4 nanoparticles were characterized using Scanning Electron Microscopy (SEM), X-Ray Diffraction (XRD), and Electron Spin Resonance (ESR) respectively. The results showed that the ratio enhancement between chitosan:Fe3O4 increased the particle size, while the crystallite size decreased. Morphology and particle size were also influenced by the ratio of crosslinkers. It was found that the higher tripolyphosphate content contributed to the smaller size and more spherical morphology. In addition, the influence of crosslinking time toward crystallite size was determined by tuning stirring time. The result showed that the longer duration of crosslinking time, the larger crystallite size of chitosan-coated Fe3O4 was obtained.

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“…46,47 All other remaining spectra showed a broad O−H stretch peak at ∼3425 cm −1 and peak at ∼2900 cm −1 for the C−H stretch. CM-β-CD sodium salt (Figure 2b) had bands at 1419 and 1602 cm −1 corresponding to the symmetrical and asymmetrical stretching vibration of the carboxylate groups, respectively.…”

Section: Ft-irmentioning

confidence: 99%

pH-Triggered Release of Hydrophobic Molecules from Self-Assembling Hybrid Nanoscaffolds

Lü

Unsworth

2016

Biomacromolecules

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Vous avez des questions? Nous pouvons vous aider. Pour communiquer directement avec un auteur, consultez la première page de la revue dans laquelle son article a été publié afin de trouver ses coordonnées. Si vous n'arrivez pas à les repérer, communiquez avec nous à PublicationsArchive-ArchivesPublications@nrc-cnrc.gc.ca. Questions? Contact the NRC Publications Archive team atPublicationsArchive-ArchivesPublications@nrc-cnrc.gc.ca. If you wish to email the authors directly, please see the first page of the publication for their contact information. NRC Publications Archive Archives des publications du CNRCThis publication could be one of several versions: author's original, accepted manuscript or the publisher's version. / La version de cette publication peut être l'une des suivantes : la version prépublication de l'auteur, la version acceptée du manuscrit ou la version de l'éditeur. For the publisher's version, please access the DOI link below./ Pour consulter la version de l'éditeur, utilisez le lien DOI ci-dessous.http://doi.org/10.1021/acs.biomac.6b00040Access and use of this website and the material on it are subject to the Terms and Conditions set forth at pH-triggered release of hydrophobic molecules from self-assembling hybrid nanoscaffolds Lu, Lei; Unsworth, Larry D.http://nparc.cisti-icist.nrc-cnrc.gc.ca/fra/droits L'accès à ce site Web et l'utilisation de son contenu sont assujettis aux conditions présentées dans le site LISEZ CES CONDITIONS ATTENTIVEMENT AVANT D'UTILISER CE SITE WEB. NRC Publications Record / Notice d'Archives des publications de CNRC:http://nparc.cisti-icist.nrc-cnrc.gc.ca/eng/view/object/?id=9e4287db-e138-42bd-a2f4-805f4418351b http://nparc.cisti-icist.nrc-cnrc.gc.ca/fra/voir/objet/?id=9e4287db-e138-42bd-a2f4-805f4418351b pH-Triggered Release of Hydrophobic Molecules from SelfAssembling Hybrid Nanoscaffolds Lei Lu †, ‡ and Larry D. Unsworth* , †, ‡ † Department of Chemical and Materials Engineering, University of Alberta, Edmonton, Alberta T6G 2V4, Canada ‡ National Institute for Nanotechnology, National Research Council (Canada), Edmonton, Alberta T6G 2M9, Canada * S Supporting Information ABSTRACT: Self-assembling peptide based hydrogels have a wide range of applications in the field of tissue repair and tissue regeneration. Because of its physicochemical properties, (RADA) 4 has been studied as a potential platform for 3D cell culture, drug delivery, and tissue engineering. Despite some small molecule and protein release studies with this system, there is a lack of work investigating the controlled release of hydrophobic compounds (i.e., anti-inflammatory, anticancer, antibacterial drugs, etc.) that are important for many clinical therapies. Attempts to incorporate hydrophobic compounds into self-assembling matrices usually inhibited nanofiber formation, rather resulting in a peptide−drug complex or microcrystal formation. Herein, a selfassembling chitosan/carboxymethyl-β-cyclodextrin nanoparticle system was used to load dexamethasone, which formed within a self-assembling (RADA...

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Chitosan/TPP microparticles obtained by microemulsion method applied in controlled release of heparin

Cited by 149 publications

References 27 publications

Chelators influenced synthesis of chitosan–carboxymethyl cellulose microparticles for controlled drug delivery

Chelators influenced synthesis of chitosan–carboxymethyl cellulose microparticles for controlled drug delivery

"CHARACTERISTICS AND MAGNETIC PROPERTIES OF CHITOSAN-COATED Fe3O4 NANOPARTICLES PREPARED BY EX-SITU CO-PRECIPITATION METHOD"

pH-Triggered Release of Hydrophobic Molecules from Self-Assembling Hybrid Nanoscaffolds

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