Chitosan/Sterculia striata polysaccharides nanocomplex as a potential chloroquine drug release device

Abstract

Nanoparticles are produced by means of polyelectrolyte complexation (PEC) of oppositely charged polycationic chitosan (CH) with polyanionic polysaccharide extracted from Sterculia striata exudates (rhamnogalacturonoglycan (RG)-type polysaccharide). The nanoparticles formed with low-molar-mass CH are larger than those formed with high-molar-mass CH. This behavior is in contrast with that previously observed for other systems and may be attributed to different mechanisms related to the association of CH with RG of higher persistence length chain than that of CH. Nanoparticles harnessed with a charge ratio (n(+)/n(-)) of <1 are smaller than particles with an excess of polycations. Particles with hydrodynamic sizes smaller than 100nm are achieved using a polyelectrolyte concentration of 10(-4)gmL(-1) and charge ratio (n(+)/n(-)) of <1. The CH/RG nanoparticles are associated with chloroquine (CQ) with an efficiency of 28% and release it for up to ∼60% within ∼10h, whereas in the latter, only ∼40% of the CQ was released after 24h. The main factor that influenced drug release rate is the nanoparticle charge ratio.

Improving Encapsulation of Hydrophilic Chloroquine Diphosphate into Biodegradable Nanoparticles: A Promising Approach against Herpes Virus Simplex-1 Infection

“…Previous studies have shown a release of 52.40% of hydroxyl chloroquine sulphate from Eudragit ® RL-100 NP (EE% = 63.14%) at 8 h [54]. The encapsulation of chloroquine diphosphate was described in chitosan NP prepared by ionic gelation technique (EE% = 59.5%), which induced the release of 40% of the drug at 24 h [55]. In the present study, the amount of drug released at 10 h was about 40%, which is much slower than the previously cited studies.…”

Lipid Systems for the Delivery of Amphotericin B in Antifungal Therapy

“…In the field of polysaccharide-based oil-core nanocapsules (NCs) and their eventual use in AmB encapsulation, Sombra et al developed spherical NCs based on acetylated Sterculia striata polysaccharide (ASSP) [213]. This exudate polysaccharide is analogous to the commercial polysaccharide Karaya gum, and it has been already employed in the production of NPs through complexation with chitosan intended to deliver chloroquine drug [246]. Sombra et al carried out a hydrophobic modification of SSP, employing its derivatives in the formation of stable NCs without the use of any surfactant [213].…”

Marine Polysaccharides as a Versatile Biomass for the Construction of Nano Drug Delivery Systems

“…Under physiological conditions, some groups become negatively charged after ionization, such as the carboxylate in HA and Alg, and the sulfonate in chondroitin sulfate, thus that polysaccharide molecules can interact with positively charged polymers [ 52 , 53 ]. Figure 3 a shows a schematic diagram of the formation of NPs by electrostatic interaction between CS and semi-flexible polyethylene glycol [ 54 ]. The molecular weight and flexibility of each component will affect the particle size.…”

“… ( a ) Schematic representation of the effect of CS molar mass on the particle size of PEC formed with semi-flexible polynion, adapted from [ 54 ]. ( b ) Common preparation methods of chitosan nanocarrier for DNA/siRNA delivery.…”