Chitosan-stabilized silver nanoclusters with luminescent, photothermal and antibacterial properties

Nakal-Chidiac, Alberto; Garcı́a, Olga; García‐Fernández, Luis; Martín-Saavedra, Francisco M.; Sánchez-Casanova, Silvia; Escudero-Duch, Clara; Román, Julio San; Vilaboa, Nuria; Aguilar, María Rosa

doi:10.1016/j.carbpol.2020.116973

Cited by 35 publications

(17 citation statements)

References 90 publications

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“…The best inhibitory effect was observed for green shell powder against P. aeruginosa (3 µg mL −1 ) and E. coli (410 µg mL −1 ), followed by the blue crab dorsal carapace against S. aureus (760 µg mL −1 ); this is linked to the content of biopolymer chitin, which was previously detected in native crustacean shells by spectroscopic and x-ray diffraction methods [ 4 , 5 , 6 ]. Chitosan is a deacetylated form of chitin, the pharmacological potential of which is well reported in the literature [ 25 , 26 ]. Moreover, a moderate antibacterial (and anti-fungal) capacity of the blue crab and crab and shrimp shell had been previously reported [ 27 , 28 ]; hence the micropowder produced from wasted crab shells is suitable for all fertilizing product categories from the microbiological point of view.…”

Section: Discussionmentioning

confidence: 99%

Wasted Biomaterials from Crustaceans as a Compliant Natural Product Regarding Microbiological, Antibacterial Properties and Heavy Metal Content for Reuse in Blue Bioeconomy: A Preliminary Study

et al. 2021

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The compliance of crab shells traditionally used as a complex natural product for agricultural soil amendment with modern biofertilizers' quality and safety requirements was investigated. Shells waste from the Blue crab, Callinectes sapidus and the Green crab, Carcinus aestuarii were tested for macronutrients, heavy metals, bacteria content, and antimicrobial properties. Such information is crucial for further utilization of the biogenic powders for any composite formulation in added-value by-products. The calcium carbonate-rich hard tissue yield was 52.13% ± 0.015 (mean ± S.D.) and 64.71% ± 0.144 from the blue and green crabs, respectively. The contents of Pb, Ni, Zn, Cr (VI), and Cu were several orders of magnitude below the prescribed limit by EU biofertilizer legislation, with Fe, Mn (not prescribed), and As being the most abundant. The content of As and Cd from the material considered here was within limits. The shells contain no colony-forming units of Salmonella spp. and compliant levels of Escherichia coli; moreover, the shell micro-powder showed dose-dependent growth inhibition of Pseudomonas aeruginosa and Staphylococcus aureus. In summary, the waste crab shells present a complex natural product as plant biofertilizer following the circular economy concepts.

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Section: Discussionmentioning

confidence: 99%

Wasted Biomaterials from Crustaceans as a Compliant Natural Product Regarding Microbiological, Antibacterial Properties and Heavy Metal Content for Reuse in Blue Bioeconomy: A Preliminary Study

et al. 2021

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“…It is widely recognized that the mechanism of employing hyperthermia for killing microorganisms is destroying diverse life-fundamental molecules or structures, including protein denaturation, lipid evaporation, and cell membrane breakage [ 2 , 52 ]. To date, many kinds of PTAs, such as carbon-based nanomaterials [ 53 , 54 ], noble metal nanomaterials [ 55 , 56 ], other metal-containing nanocomposites [ 57 ], and conjugated polymers [ 35 , 36 ], have been used for antimicrobial applications and have established their unique advantages. Moreover, owing to the uneven heat distribution in the bacterial biofilms, it is difficult to completely eradicate the bacteria within the biofilms via PTT alone.…”

Section: Applications Of Low-temperature Pttmentioning

confidence: 99%

Low-Temperature Photothermal Therapy: Strategies and Applications

Duan

2021

Research

125

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Although photothermal therapy (PTT) with the assistance of nanotechnology has been considered as an indispensable strategy in the biomedical field, it still encounters some severe problems that need to be solved. Excessive heat can induce treated cells to develop thermal resistance, and thus, the efficacy of PTT may be dramatically decreased. In the meantime, the uncontrollable diffusion of heat can pose a threat to the surrounding healthy tissues. Recently, low-temperature PTT (also known as mild PTT or mild-temperature PTT) has demonstrated its remarkable capacity of conquering these obstacles and has shown excellent performance in bacterial elimination, wound healing, and cancer treatments. Herein, we summarize the recently proposed strategies for achieving low-temperature PTT based on nanomaterials and introduce the synthesis, characteristics, and applications of these nanoplatforms. Additionally, the combination of PTT and other therapeutic modalities for defeating cancers and the synergistic cancer therapeutic effect of the combined treatments are discussed. Finally, the current limitations and future directions are proposed for inspiring more researchers to make contributions to promoting low-temperature PTT toward more successful preclinical and clinical disease treatments.

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“…Under low-flux white light radiation, non-antibacterial Au 25 (Cys) 18 transfers photoelectrons to crystal violet to promote the redox reactions, thus resulting in enhanced ROS generation and bactericidal activity. In addition, chitosan-stabilized AgNCs have also been found to enhance the bactericidal ability through the PTT effect [ 76 ].…”

Section: Antibacterial Mechanisms Of Metal Nc-based Nanoantibioticsmentioning

confidence: 99%

Antibacterial metal nanoclusters

Zheng

Wei

et al. 2022

J Nanobiotechnol

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Combating bacterial infections is one of the most important applications of nanomedicine. In the past two decades, significant efforts have been committed to tune physicochemical properties of nanomaterials for the development of various novel nanoantibiotics. Among which, metal nanoclusters (NCs) with well-defined ultrasmall size and adjustable surface chemistry are emerging as the next-generation high performance nanoantibiotics. Metal NCs can penetrate bacterial cell envelope more easily than conventional nanomaterials due to their ultrasmall size. Meanwhile, the abundant active sites of the metal NCs help to catalyze the bacterial intracellular biochemical processes, resulting in enhanced antibacterial properties. In this review, we discuss the recent developments in metal NCs as a new generation of antimicrobial agents. Based on a brief introduction to the characteristics of metal NCs, we highlight the general working mechanisms by which metal NCs combating the bacterial infections. We also emphasize central roles of core size, element composition, oxidation state, and surface chemistry of metal NCs in their antimicrobial efficacy. Finally, we present a perspective on the remaining challenges and future developments of metal NCs for antibacterial therapeutics. Graphical Abstract

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Chitosan-stabilized silver nanoclusters with luminescent, photothermal and antibacterial properties

Cited by 35 publications

References 90 publications

Wasted Biomaterials from Crustaceans as a Compliant Natural Product Regarding Microbiological, Antibacterial Properties and Heavy Metal Content for Reuse in Blue Bioeconomy: A Preliminary Study

Wasted Biomaterials from Crustaceans as a Compliant Natural Product Regarding Microbiological, Antibacterial Properties and Heavy Metal Content for Reuse in Blue Bioeconomy: A Preliminary Study

Low-Temperature Photothermal Therapy: Strategies and Applications

Antibacterial metal nanoclusters

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