Chitosan-stabilized iron oxide nanoparticles for magnetic resonance imaging

Implication of Magnetic Nanoparticles in Cancer Detection, Screening and Treatment

“…The development of reactive MNPs and magnetic colloidal particles for immobilization and easy magnetic separation of biomolecules is of great importance for early detection of diseases and consequently in therapy management and treatment of cancer in early stages. Thus, chitosan-stabilized magnetite nanoparticles were synthesized and successfully applied as negative contrast agents in MRI which further led to several biomedical applications [4].…”

“…All these individual strategies are used in oncology, but the best therapeutic effect is usually assured by combining them since the modular design enables MNPs to perform multiple functions simultaneously. For example, MRI ( Figure 1A) could be applied for early diagnosis of cancer, thus the individualized treatment (chemotherapy) may be combined with MRI, in order to achieve better and faster results [3][4][5][6].…”

“…The special properties of MNPs are fully exploited in cell labeling and targeted drug delivery systems ( Figure 1B), wherein the in vivo transportation of the drugs to the specific target is performed using a magnetic field positioned properly and outside the body [4,5]. MNPs may be considered a kind of intelligent magnetic material since they absorb the heat generated by the electromagnetic wave in the alternating magnetic field [3].…”

“…Moreover, various processes to improve the magnetic properties of MNPs as well as to predict their in vivo behavior could be adjusted by modulating parameters such as size, composition, morphology or surface functionalization [5]. The most commonly used MNPs, iron oxide nanoparticles and in particular magnetite (Fe 3 O 4 ) and its oxidized form maghemite (γ-Fe 2 O 3 ) have attracted attention mainly due to their biocompatibility, low toxicity and cost, facile preparation, as well as their specific optical and magnetic properties that can be exploited in microsystems and medical devices' fabrication [3][4][5].…”

Нанокристаллы Магнетита С Повышенной Константой Магнитной Анизотропии, Наведенной Формой Частицы

“…Одним из перспективных направлений в синтезе различных типов наночастиц для биомедицины с широким спектром бактерицидных, проводящих и магнитных свойств является использование природных полисахаридов в качестве стабилизирующих и восстанавливающих агентов [9,10]. Изготовление наночастиц с помощью полисахарида возможно как в ходе одной химической реакции [9], так и в два шага, когда сначала синтезируются сами магнитные частицы, а затем их поверхность модифицируется полисахаридом [10]. Также известен метод получения таких композитных наночастиц посредством использования микроорганизмов [11,12].…”