Chitosan/Sodium Tripolyphosphate Nanoparticles: Preparation, Characterization and Application as Drug Carrier

Yang, Wenjing; Jing, Fu; Wang, Ting; He, Nongyue

doi:10.1166/jbn.2009.1067

Cited by 81 publications

(52 citation statements)

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“…10 11 The applications of drug coated polymer nanospheres and nanoparticles as drug carrier to increase the delivery of the drug have attracted much attention, [12][13][14][15][16][17] achievements of which have * Authors to whom correspondence should be addressed. been gained in vitro and clinic trail.…”

Section: Introductionmentioning

confidence: 99%

Ultrasound Mediated Drug-Loaded Nanoparticles Crossing Cell Membranes as a New Strategy to Reverse Cancer Multidrug Resistance

Zhang¹,

Jiang²,

Wang³

et al. 2011

J. Nanosci. Nanotech.

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The emergence of the multidrug resistance (MDR) phenomenon in tumor has rendered many currently available chemotherapeutic drugs ineffective. Although many strategies have been explored to overcome MDR, the results have been disappointing to the obstacle. The aim of this study was to investigate whether the new strategy of combining drug-loaded nanoparticles (Nps) and ultrasound (US) would show useful effects on the reversal of MDR in tumor. The MDR leukemia K562/A02 cells were treated with the daunorubicin (DNR)-loaded TiO2 Nps drug carrier and US exposure. We observed good biocompatibility of the therapeutic approach, and the fresh evidence from the electrochemical studies, MTT assays, and caspase-3 immunocytochemistry demonstrated that the strategy could significantly increase the uptake of DNR by drug-resistant leukemia cells, and enhance the sensitivity of the MDR cells to the chemotherapeutic agents after released in the cells. The resisting fold became obviously lower and the apoptosis was induced in the cells as well. It was therefore concluded that the strategy could have good reversal ability of MDR in tumor. These findings reveal that the reversal of MDR in tumor by US mediated drug-loaded Nps crossing cell membranes could represent promising approach in cancer therapy.

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Section: Introductionmentioning

confidence: 99%

Ultrasound Mediated Drug-Loaded Nanoparticles Crossing Cell Membranes as a New Strategy to Reverse Cancer Multidrug Resistance

Zhang¹,

Jiang²,

Wang³

et al. 2011

J. Nanosci. Nanotech.

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“…Many studies have been published for the application of this natural polymer in order to encapsulate nanoparticles, and deliver it to the targeted tumor site (16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27). Therefore, chitosan nanoparticles are considered to be promising colloidal drug carriers for targeted drug delivery to specific sites, as well as in the treatment of cancer, delivery of vaccines, and gene delivery applications (28,29).…”

Section: Introductionmentioning

confidence: 99%

Preparation, Characterization, and Optimization of Folic Acid-Chitosan-Methotrexate Core-Shell Nanoparticles by Box-Behnken Design for Tumor-Targeted Drug Delivery

et al. 2016

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Abstract. The objective of this study was to investigate the combined influence of independent variables in the preparation of folic acid-chitosan-methotrexate nanoparticles (FA-Chi-MTX NPs). These NPs were designed and prepared for targeted drug delivery in tumor. The NPs of each batch were prepared by coaxial electrospray atomization method and evaluated for particle size (PS) and particle size distribution (PSD). The independent variables were selected to be concentration of FA-chitosan, ratio of shell solution flow rate to core solution flow rate, and applied voltage. The process design of experiments (DOE) was obtained with three factors in three levels by Design expert software. Box-Behnken design was used to select 15 batches of experiments randomly. The chemical structure of FA-chitosan was examined by FTIR. The NPs of each batch were collected separately, and morphologies of NPs were investigated by field emission scanning electron microscope (FE-SEM). The captured pictures of all batches were analyzed by ImageJ software. Mean PS and PSD were calculated for each batch. Polynomial equation was produced for each response. The FE-SEM results showed the mean diameter of the core-shell NPs was around 304 nm, and nearly 30% of the produced NPs are in the desirable range. Optimum formulations were selected. The validation of DOE optimization results showed errors around 2.5 and 2.3% for PS and PSD, respectively. Moreover, the feasibility of using prepared NPs to target tumor extracellular pH was shown, as drug release was greater in the pH of endosome (acidic medium). Finally, our results proved that FAChi-MTX NPs were active against the human epithelial cervical cancer (HeLa) cells.

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“…The CS and its derivatives have been widely used for medical and pharmaceutical applications in artificial organs, 9 targeted drug delivery, [10][11][12] drug transport, 13 gene transfers, 14 15 et cetera. Micro/nanoparticles based on CS are therefore currently receiving interests and applications, as a kind of renewable bio-material and second most abundant bio-polymer in nature.…”

Section: Introductionmentioning

confidence: 99%

Preparation of Chitosan-Sodium Sodium Tripolyphosphate Nanoparticles via Reverse Microemulsion-Ionic Gelation Method

Hu¹,

Zhang²,

Wang³

et al. 2015

j bionanosci

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In this study, chitosan (CS)-sodium sodium tripolyphosphate (STPP) (CS-STPP) nanoparticles were fabricated via reverse microemulsion-ionic gelation method. A series of experiments were conducted to optimize the constitution of reverse microemulsion system and the obtained CS-STPP nanoparticles were then characterized by Fourier transform infrared spectrum (FT-IR) and scanning electron microscope (SEM). The concentration of Tween-80 and Span-80 were 6% and 2% respectively when the ratio of water phase to oil phase was 1/7. A narrow size distribution and good dispersion of the obtained CS-STPP nanoparticles were obtained when the stirring speed was 400 rpm/min, with diameter being 552 ± 14 nm. The FT-IR results for the CS-STPP nanoparticles also indicated that the CS was cross-linked with the STPP. These results are very important for the CS-STPP nanoparticles when used as drug carriers.

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Chitosan/Sodium Tripolyphosphate Nanoparticles: Preparation, Characterization and Application as Drug Carrier

Cited by 81 publications

References 0 publications

Ultrasound Mediated Drug-Loaded Nanoparticles Crossing Cell Membranes as a New Strategy to Reverse Cancer Multidrug Resistance

Ultrasound Mediated Drug-Loaded Nanoparticles Crossing Cell Membranes as a New Strategy to Reverse Cancer Multidrug Resistance

Preparation, Characterization, and Optimization of Folic Acid-Chitosan-Methotrexate Core-Shell Nanoparticles by Box-Behnken Design for Tumor-Targeted Drug Delivery

Preparation of Chitosan-Sodium Sodium Tripolyphosphate Nanoparticles via Reverse Microemulsion-Ionic Gelation Method

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