Chitosan scaffolds: Expanding horizons in biomedical applications

Gholap, Amol D.; Rojekar, Satish; Kapare, Harshad S.; Vishwakarma, Nikhar; Raikwar, Sarjana; Garkal, Atul; Mehta, Tejal A.; Jadhav, Harsh; Prajapati, Mahendra Kumar; Annapure, Uday

doi:10.1016/j.carbpol.2023.121394

Cited by 27 publications

(6 citation statements)

References 316 publications

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“…The scaffolds studied in this research were synthesized from chitosan, a product known for its significant biological properties such as biocompatibility, biodegradability/resorption, and the ability to interact with various cells and extracellular matrix. 85 The histological results for formulation 1 are consistent with the healing of a biocompatible material implanted subdermally. The presence of a fibrous capsule is considered a normal response to implanted materials and serves as a control mechanism by the immune system to ensure that the healing process continues while the material is being reabsorbed/degraded.…”

Section: Resultssupporting

confidence: 61%

“…Fig. 11L, numerous phagocytic cells are visible within the scaffold's interbrillar spaces.The scaffolds studied in this research were synthesized from chitosan, a product known for its signicant biological properties such as biocompatibility, biodegradability/resorption, and the ability to interact with various cells and extracellular matrix 85. The histological results for formulation 1 are consistent with the healing of a biocompatible material implanted subdermally.…”

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confidence: 81%

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Biological activity of lyophilized chitosan scaffolds with inclusion of chitosan and zinc oxide nanoparticles

Viloria Angarita,

Insuasty,

Rodríguez M.

et al. 2024

RSC Adv.

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Section: Resultssupporting

confidence: 61%

mentioning

confidence: 81%

Biological activity of lyophilized chitosan scaffolds with inclusion of chitosan and zinc oxide nanoparticles

Viloria Angarita,

Insuasty,

Rodríguez M.

et al. 2024

RSC Adv.

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“…At the same time, in order to prove the high usability of their equipment, they also printed bionic tubes that can be anatomically matched to human facial nerves, but there is a lack of relevant research to verify its effectiveness. Three-dimensional printing technology has a high degree of digitalization and good repeatability, but its work efficiency is low and, due to its additive manufacturing characteristics, the precision of the preparation of fine structures, especially the control of the porous size, also needs to be improved [116].…”

Section: Copolymer or A Blend Of Polymersmentioning

confidence: 99%

Porous Organic Materials in Tissue Engineering: Recent Advances and Applications for Severed Facial Nerve Injury Repair

Sun,

Cao,

Pan

et al. 2024

Molecules

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The prevalence of facial nerve injury is substantial, and the restoration of its structure and function remains a significant challenge. Autologous nerve transplantation is a common treatment for severed facial nerve injury; however, it has great limitations. Therefore, there is an urgent need for clinical repair methods that can rival it. Tissue engineering nerve conduits are usually composed of scaffolds, cells and neurofactors. Tissue engineering is regarded as a promising method for facial nerve regeneration. Among different factors, the porous nerve conduit made of organic materials, which has high porosity and biocompatibility, plays an indispensable role. This review introduces facial nerve injury and the existing treatment methods and discusses the necessity of the application of porous nerve conduit. We focus on the application of porous organic polymer materials from production technology and material classification and summarize the necessity and research progress of these in repairing severed facial nerve injury, which is relatively rare in the existing articles. This review provides a theoretical basis for further research into and clinical interventions on facial nerve injury and has certain guiding significance for the development of new materials.

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“…Chitosan is widely recognized for its advantageous properties such as biocompatibility, low antigenicity, and biodegradability. Chitosan’s versatility finds expression in diverse fields, with applications ranging from drug delivery systems, wound healing, and tissue engineering [ 2 , 3 ]. In tissue engineering, chitosan scaffolds provide a supportive environment for cell adhesion, proliferation, and differentiation, thereby facilitating the creation of functional tissues.…”

Section: Introductionmentioning

confidence: 99%

“…In tissue engineering, chitosan scaffolds provide a supportive environment for cell adhesion, proliferation, and differentiation, thereby facilitating the creation of functional tissues. Their antimicrobial properties further contribute to the maintenance of a sterile environment during tissue regeneration processes [ 2 , 3 , 4 ]. With these attributes, chitosan and its composite materials hold significant promise for advancing bone tissue engineering and contributing to the development of innovative solutions for regenerative medicine and biomedical research [ 5 , 6 , 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Chitosan Degradation Products, Glucosamine and Chitosan Oligosaccharide, on Osteoclastic Differentiation

Takeuchi,

Oyama,

Hatanaka

2024

BioTech

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Chitosan, a natural cationic polysaccharide derived from crustaceans and shellfish shells, is known for its advantageous biological properties, including biodegradability, biocompatibility, and antibacterial activity. Chitosan and its composite materials are studied for their potential for bone tissue repair. However, the effects of chitosan degradation products, glucosamine (GlcN) and chitosan oligosaccharide (COS), on osteoclasts remain unclear. If these chitosan degradation products promote osteoclastic differentiation, careful consideration is required for the use of chitosan and related materials in bone repair applications. Here, we assessed the effects of high (500 μg/mL) and low (0.5 μg/mL) concentrations of GlcN and COS on osteoclastic differentiation in human peripheral blood mononuclear cells (PBMCs) and murine macrophage-like RAW264 cells. A tartrate-resistant acid phosphatase (TRAP) enzyme activity assay, TRAP staining, and actin staining were used to assess osteoclastic differentiation. High concentrations of GlcN and COS, but not low concentrations, suppressed macrophage colony-stimulating factor (M-CSF)- and RANKL-dependent increases in TRAP enzyme activity, TRAP-positive multinuclear osteoclast formation, and actin ring formation in PBMCs without cytotoxicity. Similar effects were observed in the RANKL-dependent osteoclastic differentiation of RAW264 cells. In conclusion, chitosan degradation products do not possess osteoclast-inducing properties, suggesting that chitosan and its composite materials can be safely used for bone tissue repair.

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Chitosan scaffolds: Expanding horizons in biomedical applications

Cited by 27 publications

References 316 publications

Biological activity of lyophilized chitosan scaffolds with inclusion of chitosan and zinc oxide nanoparticles

Biological activity of lyophilized chitosan scaffolds with inclusion of chitosan and zinc oxide nanoparticles

Porous Organic Materials in Tissue Engineering: Recent Advances and Applications for Severed Facial Nerve Injury Repair

Effect of Chitosan Degradation Products, Glucosamine and Chitosan Oligosaccharide, on Osteoclastic Differentiation

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