Chitosan–PVA–PVP/nano-clay composite: a promising tool for controlled drug delivery

Ali, Mohsin; Mir, Sadullah; Atanase, Leonard I.; Abid, Obaid-Ur-Rahman; Kazi, Mohsin

doi:10.1039/d4ra02959c

RSC Adv.

2024

DOI: 10.1039/d4ra02959c

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Chitosan–PVA–PVP/nano-clay composite: a promising tool for controlled drug delivery

Mohsin Ali,

Sadullah Mir,

Leonard I. Atanase

et al.

Abstract: Chitosan, polyvinyl alcohol (PVA), and polyvinyl pyrrolidone (PVP) were used to formulate a controlled transdermal drug delivery system for tramadol.

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Cited by 3 publications

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Synthesis and applications of chitosan derivatives in food preservation-A review

Fatima,

Mir,

Ali

et al. 2024

European Polymer Journal

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Synthesis and applications of chitosan derivatives in food preservation-A review

Fatima,

Mir,

Ali

et al. 2024

European Polymer Journal

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Comparative study for removal of potentially toxic metals from the groundwater of Lakhanpur Area, Odisha, India by using two different hydrogels

Barik,

Rekha Sahoo,

Biswal

2025

Separation and Purification Technology

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Development of Halloysite Nanohybrids-Based Films: Enhancing Mechanical and Hydrophilic Properties for Wound Healing

Rodríguez Pozo,

Ianev,

Martínez Rodríguez

et al. 2024

Pharmaceutics

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Most of the therapeutic systems developed for managing chronic skin wounds lack adequate mechanical and hydration properties, primarily because they rely on a single component. This study addresses this issue by combining organic and inorganic materials to obtain hybrid films with enhanced mechanical behavior, adhesion, and fluid absorption properties. To that aim, chitosan/hydrolyzed collagen blends were mixed with halloysite/antimicrobial nanohybrids at 10% and 20% (w/w) using glycerin or glycerin/polyethylene glycol-1500 as plasticizers. The films were characterized through the use of Fourier-transform infrared (FTIR) spectroscopy, thermogravimetric analysis (TGA), and electron microscopy. The mechanical properties were evaluated macroscopically using tensile tests, and at a nanoscale through atomic force microscopy (AFM) and nanoindentation. Thermodynamic studies were conducted to assess their hydrophilic or hydrophobic character. Additionally, in vitro cytocompatibility tests were performed on human keratinocytes. Results from FTIR, TGA, AFM and electron microscopy confirmed the hybrid nature of the films. Both tensile tests and nanomechanical measurements postulated that the nanohybrids improved the films’ toughness and adhesion and optimized the nanoindentation properties. All nanohybrid-loaded films were hydrophilic and non-cytotoxic, showcasing their potential for skin wound applications given their enhanced performance at the macro- and nanoscale.

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Chitosan–PVA–PVP/nano-clay composite: a promising tool for controlled drug delivery

Abstract: Chitosan, polyvinyl alcohol (PVA), and polyvinyl pyrrolidone (PVP) were used to formulate a controlled transdermal drug delivery system for tramadol.

Cited by 3 publications

References 54 publications

Synthesis and applications of chitosan derivatives in food preservation-A review

Synthesis and applications of chitosan derivatives in food preservation-A review

Comparative study for removal of potentially toxic metals from the groundwater of Lakhanpur Area, Odisha, India by using two different hydrogels

Development of Halloysite Nanohybrids-Based Films: Enhancing Mechanical and Hydrophilic Properties for Wound Healing

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