“…In addition, an increase in the concentration of AGEs is also found in patients with Alzheimer's disease (Ahmed et al ., ). Our previous reports reveal that either aristolochic acid or gentamicin‐induced renal injury is related to the accumulation of MG (Li et al, ; Li, Shih, & Lee, ; Huang, Chen, Li, & Lee, ; Chou, Chen, Li, Huang, & Lee, ; Chou, Li, Chen, Shih, & Lee, ). The glyoxalase system (GLO) plays a vital role in detoxifying reactive MG. MG consumes GSH to transform S ‐ d ‐lactoyl‐glutathione using GLO1 and subsequently transforms to d ‐lactate by GLO2 (McKinney & Gocke, ) as shown in Figure .…”