Chitosan/pectin polyelectrolyte complexes: Selection of suitable preparative conditions for colon-specific delivery of vancomycin

Bigucci, Federica; Luppi, Barbara; Cerchiara, Teresa; Sorrenti, Milena; Bettinetti, Giampiero; Rodriguez, Lorenzo; Zecchi, Vittorio

doi:10.1016/j.ejps.2008.09.004

Cited by 198 publications

(97 citation statements)

References 18 publications

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“…Mucoadhesion offers the advantage of extending the dosage form residence time along the GIT, which could enhance the oral bioavailability and efficacy of treatment (Bigucci et al, 2008). Fortunately, pectin shows maximum mucoadhesion on the large intestinal tissue compared to other regions of the GIT, which represents an added advantage for colon targeting (Thirawong et al, 2007).…”

Section: In Vitro Mucoadhesion Studiesmentioning

confidence: 99%

“…The spectrum of pectin ( Figure 2B) shows a broad band between 3600 and 3000 cm À1 due to stretching of its OH groups in addition to two important bands: low-intensity band at 1740 cm À1 and a stronger one at 1639 cm À1 which are attributed to the esterified and non-esterified carboxyl groups of pectin, respectively (Maestrelli et al, 2008a). Chitosan spectrum ( Figure 2C) shows the characteristic bands of amidic C¼O stretching at 1652 cm À1 and of amidic N-H bending at 1580 cm À1 (Bigucci et al, 2008). The spectrum of empty MPs evidenced disappearance of pectin band at 1740 cm À1 and strong reduction in the intensity of carboxylate ion band which was also shifted to lower wave number (1635 cm À1 ), both indicative of Zn-pectinate formation (Maestrelli et al, 2008b).…”

Section: Ft-ir Studiesmentioning

confidence: 99%

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Development and in vitro/in vivo evaluation of Zn-pectinate microparticles reinforced with chitosan for the colonic delivery of progesterone

et al. 2015

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The colon is a promising target for drug delivery owing to its long transit time of up to 78 h, which is likely to increase the time available for drug absorption. Progesterone has a short elimination half-life and undergoes extensive first-pass metabolism, which results in very low oral bioavailability ($25%). To overcome these shortcomings, we developed an oral multiparticulate system for the colonic delivery of progesterone. Zn-pectinate/chitosan microparticles were prepared by ionotropic gelation and characterized for their size, shape, weight, drug entrapment efficiency, mucoadhesion and swelling behavior. The effect of crosslinking pH, cross-linking time and chitosan concentration on progesterone release were also studied. Spherical microparticles having a diameter of 580-720 mm were obtained. Drug entrapment efficiency of $75-100% was obtained depending on the microparticle composition. Microparticle mucoadhesive properties were dependent on the pectin concentration, as well as the cross-linking pH. Progesterone release in simulated gastric fluids was minimal (3-9%), followed by burst release at pH 6.8 and a sustained phase at pH 7.4. The in vivo study revealed that the microparticles significantly increased progesterone residence time in the plasma and increased its relative bioavailability to $168%, compared to the drug alone. This study confirms the potential of Zn-pectinate/chitosan microparticles as a colon-specific drug delivery system able to enhance the oral bioavailability of progesterone or similar drugs.

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Section: In Vitro Mucoadhesion Studiesmentioning

confidence: 99%

Section: Ft-ir Studiesmentioning

confidence: 99%

Development and in vitro/in vivo evaluation of Zn-pectinate microparticles reinforced with chitosan for the colonic delivery of progesterone

et al. 2015

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“…Absorption at 1627.92 cm -1 is a specific absorption for -COOH group [14]- [16]. CMC-Pec-BADGE characterization by using FTIR shows that this material has an active force hydroxide (-OH) indicated by the spectra with wave numbers 3425.58 cm -1 and the active carboxylic group (-COOH) at wave number 1604.77 cm -1 and bands related to C=O stretching of the ester could be observed at 1743,65 cm -1 [17]- [19]. Peak on 833.25 show peak of C-H substituted para on the benzene ring, it indicate BADGE have been crosslink into pectin and Chitosan.…”

Section: A Characterizationsmentioning

confidence: 97%

Biosorption of Pb(II) Ion by Crosslinked Pectin-CMC with BADGE (Bisphenol A Diglycidyl Ether) through Reflux Method

Hastuti¹,

Mudasir²,

Siswanta³

et al. 2015

IJESD

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Abstract-The aim of this study was to develop a procedure for preparing biosorbent from natural material pectin and chitosan. The method to prepare biosorbent pectin-CMC-BADGE is established by using Reflux method. Pectincarboxymethyl chitosan crosslinked with BADGE (bisphenol A diglycidyl ether) where BADGE was used as the crosslinking agen and chitosan was grafted with acetate to form carboxymetyl chitosan (CMC). The result of this study was biosorbent Pectin-CMC-BADGE could increased sorption capacity for remove heavy metal ions in waste water by adsorb lead (II) ion. The structure and the morphology of the resulting adsorbent were characterized by Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM). The mass adsorbent adsorb Pb (II) was 15 mg with 94.78% of adsorption and adsorption capacity was 30.29 mg/g. Optimum contact time to adsorb Pb (II) was 60 minutes with 99.13% of adsorption and adsorption capacity was 44.33 mg/g. Optimum pH to adsorb Pb (II) was at pH 5 with 97.73% of adsorption and adsorption capacity was 45.03 mg/g.

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“…Devido a esta propriedade, a quitosana pode ser considerada uma matriz polimérica promissora específica para liberação de fármaco no cólon. [94][95][96] Succinato de quitosana e ftalato de quitosana também têm sido usados com sucesso como matrizes potenciais para liberação específica de diclofenaco de sódio no cólon por via oral. 94 Sistemas para liberação no cólon contendo paracetamol, mesalazina e insulina têm sido estudados com resultados satisfatórios.…”

Section: Figura 2 Microscopia Eletrônica De Varredura Das Microesferunclassified

Quitosana: biopolímero funcional com potencial industrial biomédico

Laranjeira¹,

Fávere²

2009

Quím. Nova

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Recebido em 27/1/09; aceito em 13/3/09; publicado na web em 2/4/09 CHITOSAN: FUNCTIONAL BYOPOLYMER WITH BIOMEDICAL INDUSTRIAL POTENTIAL. The importance of chitosan has grown significantly over the last two decades due to its renewable and biodegradable source, and also because of the recent increase in the knowledge of its functionality in the technological and biomedical applications. The present article reviews the biopolymer chitosan and its derivatives as versatile biomaterials for potential drug delivery systems, as well as tissue engineering applications, analgesia and treatment of arthritis.

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Chitosan/pectin polyelectrolyte complexes: Selection of suitable preparative conditions for colon-specific delivery of vancomycin

Cited by 198 publications

References 18 publications

Development and in vitro/in vivo evaluation of Zn-pectinate microparticles reinforced with chitosan for the colonic delivery of progesterone

Development and in vitro/in vivo evaluation of Zn-pectinate microparticles reinforced with chitosan for the colonic delivery of progesterone

Biosorption of Pb(II) Ion by Crosslinked Pectin-CMC with BADGE (Bisphenol A Diglycidyl Ether) through Reflux Method

Quitosana: biopolímero funcional com potencial industrial biomédico

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