Chitosan Oligosaccharides Show Protective Effects in Coronary Heart Disease by Improving Antioxidant Capacity via the Increase in Intestinal Probiotics

Jiang, Tiechao; Xing, Xiaohong; Zhang, Lirong; Liu, Zhen; Zhao, Jidong; Liu, Xin

doi:10.1155/2019/7658052

Cited by 37 publications

(25 citation statements)

References 50 publications

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“…Bonsu and Johnson (2012) reported that there was no significant change in lipid profile in rats given 10g/day inulin in individuals diagnosed with type 2 diabetes. The results of chitosan agreed with that study of Jiang et al (2019) who reported that chitosan consumption can improve lipid profiles of coronary heart disease (CHD) patients. Chitosan and artichoke leaf extracts had significant therapeutic potential in hypercholesterolemia, cardio protective effects and exerts the amelioration of the imbalance of circulated cholesterol and lipoprotein levels in HF diet-fed rats (Küçükgergin et al, 2010 andChiu et al, 2020).…”

Section: Serum Lipid Profile Of Obese Rats Fed On Artichoke Stem By-product (Asp) and Shrimp By-product (Sbp)supporting

confidence: 90%

Effect of the Diets Supplemented with Artichoke and Shrimp by-Products on Obese Rats

Elnaga

Massoud

El-Razek

et al. 2021

Alexandria Science Exchange Journal

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Foods supplemented with functional fiber are an effective means for prevention of diseases like obesity, cardiovascular diseases, and diabetes mellitus. The objective of this study was to estimate the dietary fiber content in artichoke stems by-product powder (ASP) and shrimp by-product powder (SBP) and evaluate the protective effect of diet supplemented with their byproducts as natural dietary fiber on weight gain, the blood picture, serum biochemical parameters and liver enzymes activities in obese rats. The results revealed that the crude fiber content was 22.68% in the ASP and 13.65% in SBP. Total dietary fiber fractions were composed of 18.69 and 0.42% soluble dietary fiber, 25.01 and 58.57% insoluble dietary fiber in defatted ASP and SBP, respectively. They also presented high amounts of inulin (18.2 g/100 g artichoke stem) and chitin (58.15 g/100 g shrimp shell). Biological impacts were done on the control group (CG) and compared with obese rat groups which were classified into seven groups; positive group (PC) and groups fed on diet supplemented with ASP and SBP at a level of 5 and 10%, inulin at dose 7.7 %, and chitosan at dose 2.6 %, for 8 weeks. The results showed significant improvement and ameliorated reduction in final body weight, body weights gain (%) and feed efficiency ratio (FER) in all the treated groups compared with the PC. Administration of 10% ASP or SBP significantly decreased body weight by 37.66 and 35.61%, respectively as compared to the high fat diet (HFD) group, while the highest reduction in body weight gain and lower FER were obtained in groups fed on chitosan. Feeding obese rats on diet containing ASP and SBP led to a reduction in the total cholesterol, triglycerides, and low-density lipoprotein cholesterol concentration, decreased in blood glucose level and improved serum liver enzymes activity and antioxidant enzyme activity as compared to the positive group. ASP as a source of inulin and SBP as a source of chitin can be used in the nutraceutical formulation of functional food products and a good source of natural dietary fiber to enhance the nutritional quality for prevention of diseases like obesity, and its associated health risks.

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Section: Serum Lipid Profile Of Obese Rats Fed On Artichoke Stem By-product (Asp) and Shrimp By-product (Sbp)supporting

confidence: 90%

Effect of the Diets Supplemented with Artichoke and Shrimp by-Products on Obese Rats

Elnaga

Massoud

El-Razek

et al. 2021

Alexandria Science Exchange Journal

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“…The authors evaluated the effects of chitosan oligo-Circula.ting antioxidant levels were higher in the COS group than in the control group. COS [128] saccharides (COS) on corona.ty heart disease (CHD) consumption increased tbe serum levels of SOD and GSH and reduced the levels of ALT patients.…”

Section: Chito1an Oligosacebarides (Cos)mentioning

confidence: 99%

An Overview of Structural Aspects and Health Beneficial Effects of Antioxidant Oligosaccharides

Vieira

Corrêa

Peralta

et al. 2020

CPD

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Background: Non-digestible oligosaccharides are versatile sources of chemical diversity, well known for their prebiotic actions, found naturally in plants or produced by chemical or enzymatic synthesis or by hydrolysis of polysaccharides. Compared to polyphenols or even polysaccharides, the antioxidant potential of oligosaccharides is still unexplored. The aim of the present work was to provide an up-to-date, broad and critical contribution on the topic of antioxidant oligosaccharides. Methods: The search was performed by crossing the words oligosaccharides and antioxidant. Whenever possible, attempts at establishing correlations between chemical structure and antioxidant activity were undertaken. Results: The most representative in vitro and in vivo studies were compiled in two tables. Chitooligosaccharides and xylooligosaccharides and their derivatives were the most studied up to now. The antioxidant activities of oligosaccharides depend on the degree of polymerization and the method used for depolymerization. Other factors influencing the antioxidant strength are solubility, monosaccharide composition, the type of glycosidic linkages of the side chains, molecular weight, reducing sugar content, the presence of phenolic groups such as ferulic acid, and the presence of uronic acid, among others. Modification of the antioxidant capacity of oligosaccharides has been achieved by adding diverse organic groups to their structures, thus increasing also the spectrum of potentially useful molecules. Conclusion: A great amount of high-quality evidence has been accumulating during the last decade in support of a meaningful antioxidant activity of oligosaccharides and derivatives. Ingestion of antioxidant oligosaccharides can be visualized as beneficial to human and animal health.

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“…Previous compelling investigations have demonstrated that during the suckling period, Lactobacillus plays a protective role against oxidative damage by upregulating the expression of glutathione reductase and glutathione S-transferase [73,74]. The Lachnospiraceae family participates in the breakdown of carbohydrates and potentially contributes to antioxidative properties [75].…”

Section: The Reshaped Colon Microbiota In Piglets By Smm914mentioning

confidence: 99%

Antioxidant Potential of Pediococcus Pentosaceus Strains From the Sow Milk Bacterial Collection in Weaned Piglets

Wang

Liu

Zhou

et al. 2020

Preprint

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Background: In modern animal husbandry, the relationship between sow and piglets is closely linked as breeders pay more attention to improving sow nutrition during pregnancy and lactation to favor the growing of neonates. Sow milk is the main food for piglets during their first three weeks of life, which is not only a rich repository of essential nutrients and a broad range of bioactive compounds, but also an indispensable source of commensal bacteria. Maternal milk microorganisms are important sources of commensal bacteria for neonatal gut. Bacteria from hosts’ maternal milk may serve as an additive to confer a health benefit on the composition of the indigenous microbiota of piglets.Methods: We first obtained isolates from the sow milk microbiota by the culturomics methods of continuous culture and interval sampling. Then, identified and grouped them based on a nonredundant set of 16S rDNA gene sequences. After assessing their antimicrobial activity against enteropathogens in vitro, we selected several strains to further conduct assay in Drosophila to evaluate their resistance against oxidative injury. We finally screened out Pediococcus pentosaceus (P. pentosaceus) SMM914 as candidate strain to verify its antioxidant effect in weaned piglets and study its probiotic function by 16S rDNA sequencing, metabolomics, western blotting and enzyme activity analysis.Results: The 1240 isolates were screened out from the sow milk microbiota and grouped into 271 bacterial taxa. We evaluated 80 Pediococcus isolates about their inhibition ability against enteropathogens in vitro and then chose top 10 isolates to further test them in Drosophila. In 80 Pediococcus isolates, P. pentosaceus SMM914 showed best performance by inhibition ability against enteropathogens in vitro andparaquat challenge in Drosophila model. Pretreatment of piglets with SMM914 induces the Nrf2/Keap1 antioxidant signaling pathway and altered the pathways of amino acid metabolism and lipid metabolism in plasma. In colon, Lactobacillus was significantly increased in the high dose of SMM914 group compared with the control group.Conclusion: Our study provided useful resources for deeply understanding the relationships between the maternal microbiota and the offspring and supported the theory of Sow and Piglet Integration.

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Chitosan Oligosaccharides Show Protective Effects in Coronary Heart Disease by Improving Antioxidant Capacity via the Increase in Intestinal Probiotics

Cited by 37 publications

References 50 publications

Effect of the Diets Supplemented with Artichoke and Shrimp by-Products on Obese Rats

Effect of the Diets Supplemented with Artichoke and Shrimp by-Products on Obese Rats

An Overview of Structural Aspects and Health Beneficial Effects of Antioxidant Oligosaccharides

Antioxidant Potential of Pediococcus Pentosaceus Strains From the Sow Milk Bacterial Collection in Weaned Piglets

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