Chitosan oligosaccharides protect mice from LPS challenge by attenuation of inflammation and oxidative stress

Qiao, Ying; X, Bai; Du, Yuguang

doi:10.1016/j.intimp.2010.10.016

Cited by 154 publications

(94 citation statements)

References 43 publications

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“…20,24,25) In the present study, pro-inflammatory mediators, such as TNF-α, IL-1β, and iNOS mRNA were markedly increased in CCl 4 -induced acute liver injury. Prophylactic treatment with gomisin A led to a decrease in the expression of these mediators.…”

Section: Discussionsupporting

confidence: 55%

The Molecular Mechanisms of the Hepatoprotective Effect of Gomisin A against Oxidative Stress and Inflammatory Response in Rats with Carbon Tetrachloride-Induced Acute Liver Injury

Teraoka

Shimada

Aburada

2012

Biological & Pharmaceutical Bulletin

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Oxidative damage and inflammation are implicated in the pathogenesis of liver injury and fibrosis. In the present study, we investigated the molecular mechanism by which gomisin A conferred a hepatoprotective effect, focusing on its antioxidant and anti-inflammatory effects using rats with carbon tetrachloride (CCl 4 )-induced acute liver injury. Pretreatment with gomisin A prior to the administration of CCl 4 markedly prevented an increase in alanine aminotransferase, aspartate aminotransferase, and histological hepatic lesions. Gomisin A was also associated with a decrease in hepatic lipid peroxidation, and increased superoxide dismutase activity, suggesting that gomisin A has an antioxidant effect. In addition gomisin A treatment ameliorated mRNA levels of CCl 4 -induced inflammatory mediators, including tumor necrosis factor-α, interleukin-1β and inducible nitric oxide (NO) synthase, and the protein levels of transcriptional upregulator nuclear factor kappa B (NF-κB) and phospho-inhibitor of NF-κB (IκB). Furthermore, α-smooth muscle actin (α-SMA), a myofibroblast marker, was also inhibited by gomisin A treatment. These results suggest that gomisin A inhibits the oxidative stress and activation of NF-κB, leading to down-regulation of pro-inflammatory mediators and amelioration of fibrogenesis.Key words gomisin A; oxidative stress; inflammatory response; carbon tetrachloride; acute liver injuryThe liver has the important function of metabolizing and eliminating biological and xenobiotic compounds. Liver injury is considered to be a serious health problem leading to acute hepatitis, cholestasis, and cirrhosis. Hepatocellular injury usually leads to oxidative stress, inflammation, and activation of the innate immune system. These factors lead to the release of pro-inflammatory cytokines (that can result in hepatic necrosis) and of pro-fibrogenic cytokines that may cause increased synthesis of extracellular matrix components by activation of quiescent hepatic stellate cells (HSCs).

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Section: Discussionsupporting

confidence: 55%

The Molecular Mechanisms of the Hepatoprotective Effect of Gomisin A against Oxidative Stress and Inflammatory Response in Rats with Carbon Tetrachloride-Induced Acute Liver Injury

Teraoka

Shimada

Aburada

2012

Biological & Pharmaceutical Bulletin

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“…The MDA production induces alteration of membrane fluidity and increase of membrane fragility [36][37][38] . Early research has shown that LPS could result in oxidative damage, in which the GSH levels and the CAT activity decreased while the MDA levels increased in mice after LPS injection [14] . However, preinjection 100 mg/kg COS could smooth out the oxidative stress [14] .…”

Section: Discussionmentioning

confidence: 99%

“…In murine models, COS could reversed the decrease of glutathione (GSH) levels, and catalase (CAT) activity, and the increase of malonedialdehyde (MDA) levels in the liver, lung and kidney from LPS-induced mice [14] . In Alzheimer's disease rat, COS treatment increased hippocampal superoxide dismutase (SOD) activity level [15] , and in another in vitro study, COS exerted antioxidative effects on pancreatic islet cells in streptozotocin-induced diabetes in rats [16] .…”

Section: Introductionmentioning

confidence: 99%

ikinci

XIAOCONG¹,

XUEMEI²,

XI³

et al. 2017

Kafkas Univ Vet Fak Derg

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The purpose of this study was to investigate the effects of chitosan oligosaccharides (COS) on the antioxidative function, lymphocyte cycle and apoptosis of ileum mucosa in broiler. 640 AA broilers were randomly allocated into four groups, which were fed with diets supplemented 0, 200, 350 and 500 mg/kg of COS for six weeks, respectively. The results showed that compared with the control group, the activities of glutathione peroxidase and superoxide dismutase, the ability of total antioxidant capacity and inhibit hydroxy radical as well as the contents of glutathione in the 350 and 500 mg/kg COS groups were significantly increased, while the levels of malonedialdehyde were significantly decreased. The percentages of S and gap 2/mitosis (G2M) phases and proliferating index of ileum mucosal lymphocytes in the 350 and 500 mg/kg COS groups were increased, but, the percentages of apoptotic ileac lymphocytes were not significantly different compared with the control group. No significant difference in the levels of antioxidant function mentioned above, cell cycle phase distribution and the percentages of apoptotic ileac lymphocyte existed between the 350 and 500 mg/kg COS groups. Conclusion: dietary chitosan oligosaccharides supplements with 350 mg/kg and 500 mg/kg could improve the antioxidant function and accelerate lymphocytes proliferation, but had non-influence on lymphocytes apoptosis in the ileum mucosa of broiler. Keywords: Chitosan oligosaccharides, Lymphocyte, Antioxidant function, Cell cycle, Apoptosis Kitosan Oligosakkaritlerin Broiler İleum Mukozasında Antioksidan Fonksiyon, Lenfosit Döngüsü ve Apoptozis Üzerine Etkileri ÖzetBu çalışmanın amacı; kitosan oligosakkaritlerin (COS) broiler ileum mukozasında antioksidan fonksiyon, lenfosit döngüsü ve apoptozise olan etkilerini araştırmaktır. 640 AA broiler rastgele olarak dört gruba ayrılarak sırasıyla 0, 200, 350 ve 500 mg/kg COS içeren diyetle altı hafta süresince beslendi. Kontrol grubu ile karşılaştırıldığında 350 ve 500 mg/kg COS içeren diyetle beslenen gruplarda glutatyon peroksidaz, ve süperoksit dismutaz aktiviteleri, total antioksidan kapasite ile hidroksit radikalini inhibe etme kapasitesi ve glutatyon miktarı anlamlı derecede artarken malondialdehit seviyesi azaldı. S yüzdesi ve gap 2/mitoz (G2M) fazları ve ileum mukozal lenfositlerinin çoğalma indeksi 350 ve 500 mg/kg COS içeren diyetle beslenen gruplarda artarken, apoptotik iliak lenfositlerin yüzdesi anlamlı derece kontrol grubundan farklılık göstermedi. 350 ve 500 mg/kg COS içeren diyetle beslenen gruplar arasında yukarıda bahsi geçen antioksidan fonksiyon, hücre döngü faz dağılımı ve apoptotik iliak lenfosit yüzdeleri bakımından anlamlı fark tespit edilmedi. Sonuç olarak, diyette kitosan oligosakkaritlerin 350 ve 500 mg/kg oranında ilavesi broilerlerin ileum mukozasında antioksidan fonksiyonu geliştirerek lenfosit çoğalmasını hızlandırırken, lenfositlerde apoptozis üzerine etki etmemektedir.

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“…More recently, COS has been shown to have anti-bacterial characteristics, immuneenhancing effects, and protection against pathogenic infections (Liu et al, 2008;Okamoto et al, 2002;Xu et al, 2012). Qiao et al (2011) showed that mice can be protected from the LPS challenge by the anti-inflammatory effects of chitosan oligosaccharides. Liu et al (2008) demonstrated that supplementation of diet with 100 and 200 mg/kg COS enhanced growth performance by decreasing the incidence of diarrhea, increasing apparent digestibility, and improving small intestinal morphology in weaning pigs, while the anti-oxidation effect in vitro and in mice models has been little reported and needs to be researched further.…”

Section: Introductionmentioning

confidence: 99%

Investigation of the antioxidant activity of chitooligosaccharides on mice with high-fat diet

Han

2016

R. Bras. Zootec.

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-The objective of this study was to analyze the antioxidant activities of chitooligosaccharides (COS) both in vitro and in high-fat diet (HFD)-mouse model. In antioxidant assays in HFD-mouse model, mice were administered with normal diet, HFD, or HFD with 0.5% COS for six weeks. The administration of HFD with 0.5% COS resulted in significant increase in the activity of superoxide dismutase, catalase, and glutathione peroxidase in stomach, liver, and serum of mice as compared with the HFD-fed group, which means that COS may have certain antioxidant activity and can restore the activity of the enzymes affected by the HFD. Through morphological measurements of the small intestinal mucosa, mice fed HFD showed decreased villus height compared with other groups. On the other hand, HFD with 0.5% COS group showed similar ratio of villus height to depth compared with control mice, indicating that intestinal integrity was improved when COS was added. Chitooligosaccharides have potent antioxidant activity that can protect mice from oxidative stress.

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Chitosan oligosaccharides protect mice from LPS challenge by attenuation of inflammation and oxidative stress

Cited by 154 publications

References 43 publications

The Molecular Mechanisms of the Hepatoprotective Effect of Gomisin A against Oxidative Stress and Inflammatory Response in Rats with Carbon Tetrachloride-Induced Acute Liver Injury

The Molecular Mechanisms of the Hepatoprotective Effect of Gomisin A against Oxidative Stress and Inflammatory Response in Rats with Carbon Tetrachloride-Induced Acute Liver Injury

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Investigation of the antioxidant activity of chitooligosaccharides on mice with high-fat diet

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